Unogona sei kukohwa zvakanakira zvemitambo nenzira yakakwana?

Unogona sei kukohwa zvakanakira zvemitambo nenzira yakakwana?

Vatsvagiri veBaylor neStanford Colleges of Medicine uye masangano avo anodyidzana anoshuma mumushumo wakaburitswa muNature "Vakakwanisa kuziva molecule muropa iyo inogadzirwa panguva yekurovedza muviri uye inogona kunyatsoderedza kudya kwekudya uye kufutisa mumakonzo.

Zvinoenderana neNeuroscience Nhau, izvo zvitsva zvakawanikwa zvinogona kubatsira mukuvandudza manzwisisiro esainzi nezve physiological maitiro ayo ari pasi pekudyidzana pakati pekurovedza muviri uye kuderedza nzara.

kuderedza kufutisa

"Kugara uchirovedza muviri kwakaratidzwa kubatsira kuderedza uremu, kugadzirisa chido uye kuvandudza mararamiro emagetsi, kunyanya kune vanhu vakafuta uye vakafutisa," akadaro munyori-munyori wekudzidza Dr. Yong Shu, purofesa wevana, chikafu uye molecular biology paBaylor College.

"Kana isu (vatsvakurudzi) tichikwanisa kunzwisisa nzira iyo kurovedza muviri kunotungamirira kune izvi zvinobatsira, isu tiri pedyo nekubatsira vanhu vakawanda kuvandudza hutano hwavo," akawedzera.

"Kunzwisisa kuti kurovedza muviri kunoshanda sei pachikamu chemolecular kuchatibvumira kuti tikwanise kukohwa zvimwe zvezvakanakira," akadaro munyori-munyori Purofesa Jonathan Long, purofesa mubatsiri wepathology paStanford Medicine uye muongorori paStanford Chem-H Institute.

Vakuru nevasina simba

"Semuenzaniso, vanhu vakwegura kana vasina simba vasingakwanisi kurovedza muviri zvakakwana rimwe zuva vanogona kubatsirwa nekutora mushonga unogona kubatsira kuderedza osteoporosis, chirwere chemwoyo, kana mamwe mamiriro ezvinhu," akawedzera.

Amino acids

Xu, Long nevamwe vavo vakaita ongororo yakazara yemakomisheni eplasma akatorwa kubva kumakonzo mushure mekumhanya zvakanyanya pachitsiko. Iyo yakanyanya catalytic molecule yaive yakagadziridzwa amino acid inonzi Lac-Phe. Yakagadzirwa kubva ku lactate, inova chibereko chekurovedza muviri kwakasimba, izvo zvinokonzeresa "kupisa" kunzwa mumhasuru, uye phenylalanine, amino acid inova imwe yezvivakwa zvemapuroteni.

glucose kushivirira

Mbeva dzakafuta dzakapihwa kudya kwemafuta akawanda dzakaderedza kudya kweanenge 50% zvichienzaniswa nekudzora mbeva pamusoro penguva ye12-awa, pasina kukanganisa kufamba kwavo kana mashandisiro esimba. Kana yakashandiswa kumakonzo kwemazuva gumi, Lac-Phe yakaderedza kuunganidza kudya kwekudya uye uremu hwemuviri (nekuda kwekurasikirwa kwemafuta emuviri) uye yakagadziridzwa kushivirira kweglucose.

CNDP2 enzyme kushomeka

Vatsvakurudzi vakawanawo kuti enzyme inonzi CNDP2 inobatanidzwa mukugadzirwa kweLac-Phe uye kuti mbeva dzisina kukwana mu enzyme iyi hadzina kurasikirwa nehuremu hwakawanda pahutano hwekuita sezvavakaita neboka rinodzora pane imwechete chirongwa chekudzidzira.

Kuwedzera kunoshamisa

Sezvineiwo, timu yevaongorori yakaonawo kukwirira kwakasimba muplasma Lac-Phe mazinga mushure mekuita basa rekuita mujaho uye nevanhu. Dhiyabhorosi kubva kuboka revanhu vanoita mitambo yakadai sekumhanya kwakaratidza kuti pane kuwedzera kunoshamisa kwemazinga eLac-Phe, ayo akaonekwa mushure mekuputika achiteverwa nekudzidzira kudzidzira uye kutsungirira kudzidziswa.

"Yedu (boka revanotsvakurudza) matanho anotevera anosanganisira kuwana mamwe mashoko pamusoro pekuti Lac-Phe inopindirana sei nemigumisiro yaro mumuviri, kusanganisira uropi," Dr. Shaw akati. "