Sideed uga faa'iidaysan kartaa faa'iidooyinka ciyaaraha sida ugu wanaagsan?

Sideed uga faa'iidaysan kartaa faa'iidooyinka ciyaaraha sida ugu wanaagsan?

Cilmi-baarayaasha Baylor iyo Stanford Colleges of Medicine iyo hay'adahooda iskaashiga ayaa ka warbixiyay warbixin lagu daabacay Nature "Waxay awoodeen inay aqoonsadaan molecule-ka dhiigga ku jira ee la soo saaro inta lagu jiro jimicsiga waxayna si wax ku ool ah u yareeyn karaan qaadashada cuntada iyo buurnaanta jiirarka.

Sida laga soo xigtay Neuroscience News, natiijooyinka cusub waxay gacan ka geysan karaan hagaajinta fahamka saynisyahannada ee hababka jireed ee hoosta ka xariiqay isdhexgalka ka dhexeeya jimicsiga iyo gaajada oo yaraatay.

cayilka yaree

"Jimicsiga joogtada ah ayaa lagu muujiyay inuu caawiyo miisaanka luminta, xakamaynta rabitaanka cuntada iyo hagaajinta qaabka dheef-shiid kiimikaadka, gaar ahaan dadka cayilan iyo kuwa cayilan," ayuu yiri qoraaga daraasadda Dr. Yong Shu, oo ah borofisar ku takhasusay cudurrada carruurta, nafaqada iyo bayoolajiga molecular ee Baylor College.

"Haddii annagu (cilmi-baarayaasha) aan fahmi karno habka uu jimicsigu u horseedo faa'iidooyinkan, waxaan ku dhownahay inaan caawinno dad badan inay horumariyaan caafimaadkooda," ayuu raaciyay.

"Fahamka sida jimicsigu u shaqeeyo heerka molecular wuxuu noo ogolaanayaa inaan awoodno inaan helno qaar ka mid ah faa'iidooyinkeeda," ayuu yiri la-qoraa Professor Jonathan Long, kaaliyaha borofisar ku takhasusay cilmiga cudurada Stanford Medicine iyo cilmi-baare ka tirsan Machadka Stanford Chem-H.

Waayeel iyo taag daran

"Tusaale ahaan, dadka da'da ah ama dadka jilicsan ee aan awoodin jimicsi ku filan ayaa laga yaabaa inay maalin uun ka faa'iidaystaan ​​​​daawoyinka ka caawin kara hoos u dhigista lafo-jileecu, cudurrada wadnaha, ama xaalado kale," ayuu raaciyay.

Amino acids

Xu, Long iyo asxaabtoodu waxay sameeyeen falanqayn dhamaystiran oo ku saabsan xeryahooda balaasmaha ee laga soo qaaday jiirarka ka dib markii ay si xoog leh ugu ordeen mashiinka lagu tumanayo. Moleekulaha ugu firfircooni wuxuu ahaa amino acid la beddelay oo la yiraahdo Lac-Phe. Waxay ka samaysan tahay lactate, taas oo ka dhalata jimicsi adag, taas oo sababta dareenka "gubashada" murqaha, iyo phenylalanine, amino acid oo ka mid ah dhismooyinka borotiinka.

dulqaadka gulukooska

Jiirarka buuran ee la siiyay cunto dufanku ku badan yahay waxay hoos u dhigtay qaadashada cuntada qiyaastii 50% marka la barbar dhigo kantaroolka jiirarka muddo 12-saac ah, iyada oo aan wax saamayn ah ku yeelan dhaqdhaqaaqooda ama kharashaadka tamarta. Marka lagu daro jiirarka 10 maalmood, Lac-Phe waxay yaraysay qaadashada cuntada iyo miisaanka jidhka (sabato ah luminta dufanka jidhka) iyo hagaajinta dulqaadka gulukooska.

CNDP2 yaraanta enzyme

Cilmi-baadhayaashu waxay sidoo kale ogaadeen in enzim loo yaqaan 'CNDP2' ay ku lug leedahay soo saarista Lac-Phe iyo in jiirarka ku yar enzyme this ma lumin miisaan badan oo ku saabsan nidaamka jimicsiga sida ay ku sameeyeen kooxda xakamaynta isla qorshaha jimicsiga.

Korodh weyn

Waxa xiiso leh, kooxda cilmi-baarayaashu waxay sidoo kale ogaadeen sare u kac xooggan oo ku jira heerarka plasma Lac-Phe ka dib dhaqdhaqaaqa jireed ee fardaha iyo bini'aadamka. Xogta laga helay koox bini'aadan ah oo samaynaysa jimicsiga hawada sida orodka ayaa muujisay in ay jirto korodhka ugu wayn ee heerarka Lac-Phe, kaas oo soo muuqday ka dib orodka oo ay raacdo tababarka iska caabinta iyo ka dibna tababarka dulqaadka.

"Kooxdayada cilmi-baarayaasha) tillaabooyinka soo socda waxaa ka mid ah helitaanka tafaasiil dheeraad ah oo ku saabsan sida Lac-Phe u dhexdhexaadiyo saameynteeda jidhka, oo ay ku jirto maskaxda," Dr. Shaw ayaa yiri. "Ujeedadu waa in la barto sida loo beddelo dariiqa jimicsiga ujeedooyinka daaweynta. "