La mayeza anokubangela urhatyazo

La mayeza anokubangela urhatyazo

Nangona izibonakaliso ze-cholesterol ephezulu egazini ziqinisekisa ubunzima ngombono, iqela lezenzululwazi liye lagqiba ekubeni izigulane ezinokwahlukana kofuzo ezinxulumene neziyobisi ze-statin zinomngcipheko ophezulu wokuphuhlisa i-cataract.

Iziphumo zophando zangaphambili zicebise ukuba kukho ubungqina bokuba i-statins inokunyusa umngcipheko wokuphuhlisa i-cataract, ngokutsho kwe-Print, echaza i-Journal ye-American Heart Association (JAHA).

statins kuphela

Ngelixa uphononongo lwamva nje luphawula ukuba abaphandi bafumanise ukuba ezinye iijini ezilinganisa umsebenzi we-statins zinokonyusa ngokuzimeleyo umngcipheko wokuphuhlisa i-cataract.

Bachaza ukuba la mayeza anciphisa amanqanaba e-LDL cholesterol ngokuthintela i-enzyme ebizwa ngokuba yi-HMG-CoA-reductase (HMGCR).

Nangona kunjalo, uphando lwezenzululwazi luye lwaqinisekisa ukuba ukwahluka kwingingqi ye-HMGCR yofuzo kwi-genome yabantu kuchaphazela indlela izigulane ezisebenza ngayo i-cholesterol.

Emva koko, umphandi okhokelayo wophando, uNjingalwazi uJonas Jahaus, umlingani kwiQela le-Cardiac Genetics kwi-Molecular Cardiology Laboratory kwiSebe leSayensi ye-Biomedical kwiYunivesithi yaseCopenhagen eDenmark, wabika ukuba uphando alukwazanga ukufumana naluphi na unxulumano phakathi kolutsha. amayeza angengawo e-statin kunye namachiza enziwe afana nalawo aveliswe ngabenzi.

Nangona kunjalo, wagxininisa ukubaluleka kweenzuzo ze-statins zokunciphisa amanqanaba e-low-density lipoproteins kubantu abanezinga eliphezulu le-cholesterol, echaza ukuba bagqithisa iingozi ezincinci zokuphuhlisa i-cataract.

Iintlobo ezi-5 zofuzo eziqhelekileyo

Abaphandi bahlalutya idatha yofuzo yabantu abangaphezu kwe-402,000, begxininisa kwiintlobo ezintlanu ezichongiweyo ngaphambili eziye zafumanisa ukuba i-cholesterol ephantsi ye-LDL.

Amanqaku e-Genetic aye abalwa ngokusekelwe kwimpembelelo echazwe kwangaphambili yokwahluka ngalunye kwi-LDL-cholesterol. Idatha ye-genetic coding yaza yavavanywa ukuchonga abathwali benguqu enqabileyo kwi-HMGCR gene ebizwa ngokuba yi-mutation ye-loss-of-function elindelekileyo.

“Xa sithwala uguquko lwelahleko-yokusebenza, imfuza ayinakwenzeka ukuba isebenze,” utshilo uNjingalwazi Jahaus. Ukuba i-HMGCR gene ayisebenzi, umzimba awukwazi ukwenza le proteni. Ukubeka nje, ukuguqulwa kokulahleka komsebenzi kwi-HMGCR gene ilingana nokuthatha i-statin. "
inqaku lomngcipheko wemfuzo

Iziphumo zophando zibonise ukuba iingozi zofuzo ngenxa ye-HMGCR zenza ukuba abantu babe nethuba lokuphuhlisa i-cataract.

I-38.7 mg / dL nganye yehla kwi-LDL-cholesterol ngamanqaku emfuza yadibaniswa ne-14% yokwandisa ingozi yokuphuhlisa i-cataracts kunye ne-25% yokwandisa ingozi yokungenelela ngokuhlinzwa.

Isiphumo esihle

Ngokubhekiselele kwisiphumo esihle, abaphandi baxela ukuba umda omkhulu wophononongo kukuba ngelixa ukuthwala ezi zintlupheko zofuzo kubeka umngcipheko wobomi bonke wokuphuhlisa i-cataract, lo mngcipheko akufanele uvavanywe ngendlela efanayo kubantu abaqale ukuthatha i-statins kamva ebomini. I-Statins, ezinciphisa amanqanaba e-cholesterol egazini. Uvavanyo olongezelelweyo lwalo mbutho kwiimvavanyo ezininzi zekliniki ziyafuneka ukuze kuqinisekiswe ezi ziphumo.

Kuyaphawuleka ukuba ukukhuselwa kwe-cholesterol ephezulu kunye neengozi ezibangelwayo kuneendlela ezininzi, ezona zibalulekileyo kukwenza ukuguqulwa kwendlela yokuphila kunye nokuzivocavoca rhoqo, ngelixa unamathela kwisondlo esifanelekileyo, kwaye ungatshayi.

Kanye kunye nokulandelwa kunye nogqirha kwimeko yokulimala kunye nokuthobela umyalelo wokuphepha ukwenzeka kweengxaki ezinobungozi.