Le mithi ingase ibangele ulwelwesi lwamehlo

Le mithi ingase ibangele ulwelwesi lwamehlo

Nakuba izinkomba ze-cholesterol ephezulu egazini ziqinisekisa ubunzima bokubona, ithimba lososayensi liphethe ngokuthi iziguli ezinomehluko wezakhi zofuzo oxhunywe emithini ye-statin zinengozi eyengeziwe yokuba ne-cataract.

Okutholakele ocwaningweni lwangaphambilini kuphakamise ukuthi kunobunye ubufakazi bokuthi ama-statins angase andise ingozi yokuba ne-cataract, ngokusho kweThe Print, ecaphuna i-Journal of the American Heart Association (JAHA).

ama-statins kuphela

Ngenkathi ucwaningo lwakamuva luphawula ukuthi abacwaningi bathole ukuthi izakhi zofuzo ezilingisa umsebenzi wama-statins nazo zingandisa ngokuzimela ingozi yokuba nesifo samehlo.

Bachaza ukuthi le mithi imvamisa yehlisa amazinga e-LDL cholesterol ngokuvimbela i-enzyme ebizwa nge-HMG-CoA-reductase (HMGCR).

Kodwa-ke, ucwaningo lwesayensi luqinisekisile ukuthi okuhlukile esifundeni sezakhi zofuzo ze-HMGCR ku-genome yomuntu kuthinta indlela iziguli ezisebenzisa ngayo i-cholesterol.

Ngokulandelayo, umcwaningi oholayo walolu cwaningo, uSolwazi Jonas Jahaus, ozakwabo ku-Cardiac Genetics Group e-Molecular Cardiology Laboratory eMnyangweni we-Biomedical Sciences eNyuvesi yase-Copenhagen e-Denmark, ubike ukuthi ucwaningo alukwazanga ukuthola noma yikuphi ukuhlobana phakathi kwentsha. izidakamizwa okungezona ama-statin nezidakamizwa ezijwayelekile. ingozi yokwehlisa i-lipid kanye ne-cataract, ngakho-ke kungenzeka ukuthi lo mphumela uhlobene ikakhulukazi nama-statins.

Kodwa-ke, wagcizelela ukubaluleka kwezinzuzo zama-statins emazingeni aphansi we-low-density lipoprotein kubantu abanamazinga aphezulu e-cholesterol, echaza ukuthi idlula izingozi ezincane zokuthuthukisa i-cataract.

Izinhlobo ezi-5 zofuzo ezivamile

Abacwaningi bahlaziye idatha yofuzo yabantu abangaphezu kuka-402,000, begxile ezinhlobonhlobo ezinhlanu zofuzo ezikhonjwe ngaphambilini ezehlisa i-cholesterol ye-LDL.

Izikolo zofuzo zibe sezibalwa ngokusekelwe kumthelela oshiwo ngaphambili wokuhluka ngakunye ku-LDL-cholesterol. Idatha yekhodi yofuzo yabe isihlolwa ukuze kuhlonzwe abathwali benguquko engavamile esakhini sofuzo se-HMGCR esibizwa ngokuthi ukuguqulwa kokulahlekelwa komsebenzi okulindelekile.

"Uma siphethe ukuguqulwa kokulahleka kokusebenza, isakhi sofuzo mancane amathuba okuthi sisebenze," kusho uSolwazi Jahaus. Uma isakhi sofuzo se-HMGCR singasebenzi, umzimba awukwazi ukwenza le phrotheni. Kalula nje, ukuguqulwa kokulahleka kokusebenza kofuzo lwe-HMGCR kulingana nokuthatha i-statin. "
isikolo sengozi yofuzo

Imiphumela yalolu cwaningo iveze ukuthi ubungozi bolibofuzo oludalwa yi-HMGCR lwenza abantu babe maningi amathuba okuba nolwelwesi lwamehlo.

Ukwehla ngakunye kwe-38.7 mg/dL ku-LDL-cholesterol ngemiphumela yofuzo kwakuhlotshaniswa nengozi eyandayo engu-14% yokuba nesifo samehlo kanye nengozi eyandayo yokungenelela ngokuhlinzwa ngama-25%.

Umphumela omuhle

Ngokuqondene nomphumela omuhle, abacwaningi babika ukuthi umkhawulo omkhulu wocwaningo ukuthi nakuba ukuthwala lezi zinhlobo zofuzo kubeka engcupheni yempilo yonke yokuthuthukisa ulwelwesi lwamehlo, le ngozi akufanele ihlolwe ngendlela efanayo kubantu abaqale ukuthatha ama-statin kamuva ekuphileni. i-Statins, enciphisa amazinga e-cholesterol egazini. Ukuhlolwa okwengeziwe kwale nhlangano ezinhlolweni eziningi zomtholampilo kuyadingeka ukuze kuqinisekiswe lokhu okutholakele.

Kuyaphawuleka ukuthi ukuvimbela i-cholesterol ephezulu kanye nezingozi ezibangelwayo kunezindlela ezimbalwa, okubaluleke kakhulu okuwukwenza ukuguqulwa kwendlela yokuphila nokuzivocavoca njalo, ngenkathi unamathela ekudleni okufanele, futhi ungabhemi.

Kanye nokulandelelwa nodokotela uma kwenzeka kulimala futhi kulandelwa incwadi kadokotela ukuze kugwenywe ukwenzeka kwezinkinga eziyingozi.