Will nanobodies be the solution to Corona?

In the first test of nanobodies that resemble monoclonal antibodies, but are smaller, more stable and cheaper to produce, researchers from the American University of Pittsburgh School of Medicine showed that inhalable nanobodies that target the “spike” protein of the emerging coronavirus, can be To prevent and treat acute illness.

In the details of the study published in the journal "Science Advances", and conducted on hamsters, the researchers demonstrated that low doses of an aerobic nanobody called Nanobody - 21 "PiN - 21", which can be inhaled protects hamsters from the dramatic weight loss usually associated with severe virus infection. And it reduces the number of infectious virus particles in the nasal cavities, throat and lungs by a million times, compared to the placebo treatment that uses a nanobody that does not nullify the effect of the virus.

She explained that by using inhalation therapy that can be given directly to the site of infection in the respiratory tract and lungs, we can make treatments more efficient, pointing out that the hope is great, especially after the nanobody (PiN - 21) confirmed that it can be very protective against severe diseases, and can be It prevents transmission of the virus from one person to another.

Vaccine is the best solution

Scientists had to overcome many technical challenges in this research, as the nanoparticles must reach deep into the lung, and the treatment particles must be small enough so that they do not clump together and be strong enough to withstand extreme pressure.

PiN-21 nanobodies, which are about 4 times smaller than typical monoclonal antibodies with exceptionally high stability, are well suited for this task, are much cheaper to produce, and can be rapidly produced to quickly adapt to the shape-shifting virus.

In addition, the researchers pointed out that nanobodies and vaccines complement each other and do not compete with each other, and vaccines remain the best way to prevent the spread of the virus from one person to another.

She explained that the nanobodies will only be useful in treating people who are already sick and who cannot get vaccinated for other medical reasons.

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