Anan akwai mahimman hanyoyin rigakafin ciwon huhu

Anan akwai mahimman hanyoyin rigakafin ciwon huhu

An gano cewa sinadarin Zinc yana da matukar muhimmanci wajen hana kamuwa da cutar huhu a cikin masu fama da cutar cystic fibrosis, wadanda karfinsu na garkuwar jikinsu na yaki da kwayoyin cuta ya ragu saboda maye gurbin kwayoyin halittar da ke haifar da cutar. , rage kumburi..

Alamar mutuwa da wuri

A cewar shafin yanar gizon New Atlas, wanda ya ambaci mujallar PNAS, shekaru 25 da suka wuce, cystic fibrosis ya kasance mai nuna yiwuwar mutuwa da wuri, kuma yayin da tsawon rayuwa ya inganta sosai tun lokacin, mutanen da ke fama da cystic fibrosis har yanzu suna da wuyar haifar da rikitarwa. harka.

Wani maye gurbi a cikin kwayar halittar cystic fibrosis transmembrane conductance regulator (CFTR) yana haifar da tarin gamsai da yawa a cikin huhu da kuma kumburin hanyar iska, yana sa mutanen da ke da yanayin zama masu saurin kamuwa da cututtuka masu yawa. Amma masu bincike daga Jami'ar Queensland ta Ostiraliya sun yi nasarar gano hanyar da za ta iya rage cututtuka a cikin masu fama da cystic fibrosis, wanda ya dogara da zinc.

Magungunan rigakafi

"Mutanen da ke da cystic fibrosis suna da yanayin kumburi sosai a cikin hanyoyin iska kuma sun fi dacewa da cututtuka na kwayan cuta, amma maimaita magani tare da maganin rigakafi na iya haifar da cututtuka na kwayoyin cuta," in ji Peter Sly, MD, likita na numfashi na yara da kuma nazarin haɗin gwiwar. marubucin. Vitality."

Jiyya na yanzu

"Magungunan yanzu na iya mayar da bangarori da yawa na aikin CFTR, amma ba su warware ko hana cututtuka na huhu, don haka akwai buƙatar mayar da aikin rigakafi," in ji Dokta Sly.

Ta hanyar nazarin yadda maye gurbi na CFTR ke shafar ikon ƙwayoyin rigakafi, wanda ake kira macrophages, don yaƙar ƙwayoyin cuta, masu binciken sun ƙaddara cewa a cikin cystic fibrosis, macrophages huhu ba zai iya amfani da zinc da kyau a matsayin wakili na antibacterial ba.

Matakan masu guba

Matt Sweet, daya daga cikin masu bincike a cikin binciken, ya ce: "Daya daga cikin hanyoyin da kwayoyin phagocytic ke lalata kwayoyin cuta shine ta hanyar sanya su guba da matakan karafa masu guba irin su zinc," yana mai cewa "tashar CFTR ion yana da mahimmanci ga zinc. hanya, kuma saboda ba ya aiki da kyau a cikin masu kamuwa da cuta." "Tare da cystic fibrosis, yana iya yin bayanin dalilin da yasa suka fi kamuwa da cututtukan ƙwayoyin cuta."

Rashin aiki

Baya ga gano rashin aikin zinc a cikin sel, masu binciken sun kuma gano furotin jigilar jigilar zinc, SLC30A1, wanda ya dawo da ikon macrophages don kashe ƙwayoyin cuta a cikin yanayin maye gurbin CFTR, ma'ana cewa ƙarin maganin zinc shima ya isa ya dawo da kashe ƙwayoyin cuta mutum huhun macrophages in vitro.

Sabuwar dabara

Sakamakon ya nuna cewa mayar da martani ga gubar zinc za a iya bi a matsayin dabarun warkewa don maido da aikin rigakafi da ingantaccen tsaro a cikin mutanen da ke da cystic fibrosis, tare da mai bincike Sweet yana bayanin cewa manufar a halin yanzu ita ce "sadar da furotin jigilar zinc zuwa macrophages a cikin mutane. tare da cystic fibrosis tare da tsammanin zai sake farfado da martanin rigakafin su." "Yana rage kamuwa da cuta."

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