Agogon halittu

Circadian rhythm wani tsari ne na ciki na halitta wanda ke biye da zagayowar sa'o'i 24 wanda ke sarrafa barci, narkewa, ci, har ma da rigakafi.

Abubuwa kamar hasken waje, cin abinci na yau da kullun, da kasancewa tare da motsa jiki suna taimakawa wajen ci gaba da aiki da agogon halitta. Sabanin haka, yin ƙananan abubuwa kamar tsayawa kaɗan fiye da yadda aka saba, ko ma cin abinci a wani lokaci daban fiye da yadda aka saba, na iya rushe "agogo" na ciki.

Lafiyar kwakwalwa da ciwon daji

Masana kimiyya daga Cibiyar Nazarin Kimiyyar Kimiyya ta Jami'ar Jihar New York sun ba da shawarar cewa kana bukatar ka ci gaba da yin aiki yadda ya kamata, saboda an danganta rushewar wannan zagayowar da matsalolin kiwon lafiya da dama, ciki har da rashin lafiyar kwakwalwa, ciwon daji da kuma cutar Alzheimer.

Bincike ya nuna cewa ga marasa lafiya da ke da cutar Alzheimer, ana ganin rikice-rikicen rhythm na circadian a matsayin canje-canje a cikin halayen barci na majiyyaci wanda ke faruwa tun kafin cutar ta bayyana. Yanayin yana kara tsananta a cikin matakai na gaba na cutar. Amma har yanzu ba a fahimci cikakken ko rashin barci yana haifar da cutar Alzheimer ba, ko kuma yana faruwa ne sakamakon cutar.

allunan kwakwalwa

Masu bincike koyaushe suna gano wani abu na gama gari a cikin kwakwalwar mutanen da ke fama da cutar Alzheimer shine tarin sunadaran da ake kira “beta-amyloid”, wadanda sukan dunkule wuri guda a cikin kwakwalwa kuma su samar da “plaques” a cikin kwakwalwa. Beta-amyloid plaques yana rushe aikin ƙwayoyin kwakwalwa, wanda kuma zai iya haifar da matsalolin fahimta, kamar asarar ƙwaƙwalwa. A cikin kwakwalwa na yau da kullun, sunadaran suna tsaftacewa lokaci-lokaci kafin ya sami damar haifar da matsala.

nazarin halittu rhythm a kusa da nan kowane lokaci

Sakamakon binciken na baya-bayan nan ya nuna cewa sel da ke da alhakin cire plaques na beta-amyloid da kuma kiyaye lafiyar kwakwalwa suma suna bin bugun sigina na sa'o'i 24, wanda ke nufin cewa idan yanayin hawan circadian ya damu, yana iya yin wuya a cire. Kwayoyin plaque masu cutarwa masu alaƙa da cutar Alzheimer. .

macrophages

Don gudanar da binciken nasu, tawagar masu binciken sun yi nazari na musamman na macrophages, wadanda kuma ake kira macrophages kuma wadanda gaba daya ke yawo a cikin mafi yawan kyallen jikin jiki, ciki har da kwakwalwa. Macrophages galibi suna cin kwayoyin cuta ko ma sunadaran da ba a samu su yadda ya kamata ba, wadanda za a iya daukar su barazana ga jiki.

Don fahimtar ko waɗannan ƙwayoyin rigakafi suna bin rudun circadian, masu binciken sunyi amfani da macrophages da aka ɗauka daga berayen da aka yi a cikin dakin gwaje-gwaje. Kuma lokacin da suka ciyar da sel tare da beta-amyloid, sun gano cewa ikon macrophages don kawar da beta-amyloid ya canza cikin sa'o'i 24.

Protein "proteoglycans"

An kuma nuna cewa wasu sunadaran da ke saman macrophages, da ake kira proteoglycans, suna da irin wannan hawan circadian a cikin yini. Ya bayyana cewa lokacin da adadin proteoglycans ya kasance mafi ƙanƙanta, ikon share furotin na beta-amyloid ya kasance mafi girma, ma'ana cewa lokacin da macrophages ke da proteoglycans mai yawa, ba su kawar da beta-amyloid ba. Masu binciken sun kuma gano cewa a lokacin da macrophages suka rasa tsarin su na circadian na yau da kullun, sun daina yin aikin zubar da furotin na beta-amyloid kamar yadda suka saba.

Kwayoyin rigakafi na kwakwalwa

Ko da yake sabon binciken ya yi amfani da macrophages daga jikin beraye gabaɗaya ba daga kwakwalwa ba musamman, sakamakon wasu binciken ya nuna cewa microglia - ƙwayoyin rigakafi na kwakwalwa (wanda kuma nau'in macrophage ne a cikin kwakwalwa) - suna da kuma nazarin halittu na yau da kullun. kari. Agogon circadian yana daidaita duk abin da ke da alaƙa da aiki da samuwar microglia da kuma martanin rigakafin su. Yana yiwuwa microglial circadian rhythms suma suna da alhakin sarrafa hanyoyin sadarwa na jijiyoyi - wanda a ƙarshe zai iya ba da gudummawa ga mummunan alamun da ke hade da cutar Alzheimer, ko ma matsalolin barci da tsofaffi za su iya fuskanta.

Ƙarin sakamako masu karo da juna

Amma a cikin binciken da aka yi la'akari da dukkanin kwayoyin halitta (irin su mice) maimakon kawai kwayoyin halitta, binciken da aka yi a kan dangantakar dake tsakanin cutar Alzheimer da kuma circadian rhythms sun kasance masu cin karo da juna, saboda sau da yawa sukan kasa kama duk matsalolin da aka samu a cikin mutane masu cutar Alzheimer. kamar yadda ake nufi shi ne cewa kawai wasu tsarin ko sunadaran da cutar Alzheimer za ta iya shafa ne kawai ake nazarin su, wanda ke nuna cewa ba za su iya ba da cikakkiyar cikakkiyar wakilci na yadda cutar Alzheimer ke faruwa a cikin mutane ba.

cutar Alzheimer ta tsananta

A cikin nazarin mutanen da ke fama da cutar Alzheimer, masu bincike sun gano cewa rashin jin dadi na circadian na iya cutar da yanayin yayin da cutar ta ci gaba. Sauran binciken bincike kuma sun nuna cewa rushewar zaren circadian yana da alaƙa da matsalolin barci da kuma cutar Alzheimer, tare da kwakwalwar da ba ta da ikon tsaftace kwakwalwa (ciki har da beta-amyloid), mai yiwuwa ya ba da gudummawa ga matsalolin ƙwaƙwalwa. Amma yana da wuya a iya tantance ko rushewar zaren circadian (da matsalolin da yake haifarwa) na iya faruwa a sakamakon cutar Alzheimer, ko kuma idan wani bangare ne na cutar.

Ingancin bacci dole ne

Idan aka yi irin wannan a cikin mutane, binciken binciken zai iya ba da wani mataki kusa da fahimtar daya daga cikin hanyoyin da ake danganta hawan circadian da cutar Alzheimer. Daga karshe dai an yarda cewa barci yana da matukar muhimmanci ga bangarori da dama na lafiyar dan Adam, don haka kare rukunan circadian yana da mahimmanci kuma ya zama dole don kiyaye yanayin tunani, ruhi, yanayi da lafiya gaba daya.