Maganin kuraje da gabobi tare!!!

Maganin kuraje da gabobi tare!!!

Tawagar masana kimiyya da ke neman sabbin hanyoyin magance cututtukan osteoarthritis na hannu sun kai ga wani sabon ci gaba mai ban sha'awa yayin gwajin maganin da aka samar da asali don magance kuraje da psoriasis.

Masana kimiyya sun kuma iya gano cewa maganin zai iya hana ci gaban osteoarthritis na hannu a cikin nau'ikan dabbobin dakin gwaje-gwaje, kuma a halin yanzu suna aiki kan mutane don tabbatar da yuwuwar sa a matsayin sabon magani na asibiti, kamar yadda New Atlas ya buga, yana mai cewa. mujallar Kimiyya Translational Medicine.

retinoic acid

Masana kimiyya a Jami'ar Oxford ne suka gudanar da binciken, wadanda suka tashi yin nazarin bambance-bambancen gama gari a cikin wata kwayar halitta mai suna ALDH1A2 wacce ke da alaƙa da OA mai tsanani na hannu. Masu binciken sun tabbatar da wannan mahada ta hanyar zana bayanai daga binciken binciken bankin Biobank na UK, sannan kuma sun sami cartilage daga majinyata 33 OA yayin da ake yi musu tiyata.

An kuma yi nazarin waɗannan samfuran tare da samfuran gwaji, wanda ya ba ƙungiyar damar gano takamaiman ƙwayoyin cuta waɗanda ke da ƙarancin gaske a cikin mutane masu haɗari. Ana kiran kwayar halittar retinoic acid, kuma kwayoyin ALDH1A2 ne suka yi ta. Ta hanyar jerin RNA, masu binciken sun sami damar gano alaƙa tsakanin bambance-bambancen kwayoyin halitta, ƙarancin retinoic acid, da kumburi da aka gani a cikin OA.

kuraje da psoriasis

Daga nan ne masu binciken suka juya zuwa wani magani mai suna Talarozole, wanda aka samar da shi don hana metabolism na retinoic acid don magance kuraje, psoriasis da yanayin fata masu alaƙa. Lokacin da aka yi amfani da shi a cikin haɗin gwiwa na ƙirar linzamin kwamfuta, miyagun ƙwayoyi ya iya rage raunin guringuntsi da kumburi bayan sa'o'i shida. An kuma maimaita sakamakon a cikin haɗin gwiwa na porcine na ex vivo.

Osteoporosis da ciwo na kullum

Dokta Neha Essar-Brown, mawallafin binciken kuma Daraktar Nazarin Lafiya a Jami'ar Oxford, ta ce: "Binciken har yanzu yana kan matakin farko, amma tare da waɗannan sakamako masu ƙarfafawa, mun kasance babban mataki kusa da samun damar haɓakawa. wani sabon nau'in gyaran magunguna don magance osteoporosis. da arthritis."

Saboda talarozole yana da ingantaccen bayanin martabar aminci a cikin ɗan adam, masana kimiyya suna ƙulla babban bege don ingantaccen hanyar amfani da asibiti. Sun gudanar da wani ɗan ƙaramin bincike-na ra'ayi don ganin ko waɗannan sakamakon farko za a iya maimaita su, suna shimfida tushen sabon tsarin kula da OA.

nazarin halittu hari

Har ila yau, Dokta Essar-Brown ya kara da cewa, "Akwai bukatar gaggawa don maganin cututtukan cututtuka da aka tsara don hana ko juya alamun cututtuka masu zafi na rheumatoid arthritis. Wannan binciken ya bayyana sabon fahimtar abubuwan da ke haifar da osteoarthritis na hannu, wanda zai iya haifar da gano sababbin maƙasudin nazarin halittu don shiga tsakani a cikin isar OA."