Hiki i kēia mau lāʻau lapaʻau ke kumu i ka cataracts

Hiki i kēia mau lāʻau lapaʻau ke kumu i ka cataracts

ʻOiai ʻo nā hōʻailona o ka cholesterol kiʻekiʻe i loko o ke koko e hōʻoia i ka paʻakikī me ka ʻike, ua manaʻo kahi hui o nā ʻepekema ʻo ka poʻe maʻi i loaʻa nā ʻokoʻa genetic i pili i nā lāʻau statin e piʻi aʻe ka pilikia o ka hoʻomohala ʻana i nā cataracts.

Ua hōʻike ʻia nā ʻike noiʻi mua aia kekahi mau hōʻike e hiki ai i nā statins ke hoʻonui i ka pilikia o ka hoʻomohala ʻana i nā cataracts, e like me ka The Print, e haʻi ana i ka Journal of the American Heart Association (JAHA).

nā statins wale nō

ʻOiai ua ʻike ʻia ka noiʻi hou loa ua ʻike ka poʻe noiʻi i kekahi mau genes e hoʻohālike i ka hana o nā statins hiki ke hoʻonui kūʻokoʻa i ka pilikia o ka hoʻomohala ʻana i nā cataracts.

Ua wehewehe lākou ʻo kēia mau lāʻau lapaʻau e hoʻemi maʻamau i nā pae o ka LDL cholesterol ma ke kāohi ʻana i kahi enzyme i kapa ʻia ʻo HMG-CoA-reductase (HMGCR).

Eia nō naʻe, ua hōʻoia ka noiʻi ʻepekema e pili ana nā ʻano like ʻole i ka ʻāpana gene HMGCR i ka genome kanaka i ka hopena o nā mea maʻi i ka cholesterol.

ʻO ka mea noiʻi alakaʻi o ka noiʻi, ʻo Professor Jonas Jahaus, he hoa ma ka Cardiac Genetics Group ma ka Molecular Cardiology Laboratory ma ke Keʻena o Biomedical Science ma ke Kulanui o Copenhagen ma Denmark, ua hōʻike ʻia ʻaʻole hiki i ka haʻawina ke ʻike i kahi hui ma waena o nā mea hou. nā lāʻau lapaʻau non-statin a me nā lāʻau maʻamau. ʻO ka hoʻohaʻahaʻa lipid a me ka pilikia cataract, no laila pili paha kēia hopena i nā statins.

Eia nō naʻe, ua koʻikoʻi ʻo ia i ke koʻikoʻi o nā pono o nā statins i nā haʻahaʻa haʻahaʻa o nā lipoproteins haʻahaʻa haʻahaʻa i nā poʻe me nā kiʻekiʻe o ka cholesterol kiʻekiʻe, e wehewehe ana ua ʻoi aku lākou ma mua o nā liʻiliʻi liʻiliʻi o ka hoʻomohala ʻana i nā cataracts.

5 mau ʻano genetic maʻamau

Ua nānā ka poʻe noiʻi i ka ʻikepili genetic o nā kānaka ʻoi aku ma mua o 402,000, e kālele ana i ʻelima mau ʻano genetic maʻamau i ʻike mua ʻia e hoʻohaʻahaʻa i ka cholesterol LDL.

A laila ua helu ʻia nā helu genetic ma muli o ka hopena i ʻōlelo mua ʻia o kēlā me kēia ʻano ma ka LDL-cholesterol. A laila ua nānā ʻia ka ʻikepili genetic coding no ka ʻike ʻana i nā mea lawe i kahi hoʻololi ʻokoʻa ma ka gene HMGCR i kapa ʻia ka hoʻololi ʻana o ka hana i manaʻo ʻia.

"Ke lawe nei mākou i ka hoʻololi ʻana o ka hana, ʻaʻole hiki ke hana ka gene," wahi a Profesor Jahaus. Inā ʻaʻole hana ka gene HMGCR, ʻaʻole hiki i ke kino ke hana i kēia pūmua. ʻO ka waiho wale ʻana, ua like ka hoʻololi ʻana o ka hana i ka gene HMGCR me ka lawe ʻana i kahi statin.
helu pilikia genetic

Ua hōʻike ʻia nā hopena o ka noiʻi ʻana i nā pilikia genetic ma muli o ka HMGCR e hoʻonui i ka poʻe i ka hoʻomohala ʻana i nā cataracts.

ʻO kēlā me kēia 38.7 mg/dL ka emi ʻana o ka LDL-cholesterol ma o ka helu genetic i pili me ka 14% piʻi aʻe ka pilikia o ka hoʻomohala ʻana i nā cataracts a me ka 25% ka piʻi ʻana o ka hopena o ke kaʻina hana.

Ka hopena maikaʻi

No ka hopena maikaʻi, hōʻike nā mea noiʻi ʻo ka palena nui o ka noiʻi ʻana ʻoiai ʻo ka lawe ʻana i kēia mau ʻano genetic e hoʻopilikia i ke ola o ka hoʻomohala ʻana i nā cataracts, ʻaʻole pono e loiloi ʻia kēia pilikia ma ke ʻano like no ka poʻe i hoʻomaka e lawe i nā statins ma hope o ke ola. Hāʻawi ʻia ka hopena maikaʻi. ʻO nā statins, ka mea e hoʻemi i ka pae cholesterol i loko o ke koko. Pono ka loiloi hou aʻe o kēia hui i nā hoʻokolohua lapaʻau hou aku e hōʻoia i kēia mau ʻike.

Hoʻomaopopo ʻia ʻo ka pale ʻana i ka cholesterol kiʻekiʻe a me nā pilikia i loaʻa iā ia he mau ʻano hana, ʻo ka mea nui o ka hoʻololi ʻana i ke ʻano o ka nohona a me ka hoʻomaʻamaʻa mau ʻana, ʻoiai e pili ana i ka meaʻai kūpono, ʻaʻole i ka puhi ʻana.

E like me ka hahai ʻana me ke kauka inā loaʻa ka hōʻeha a me ka mālama ʻana i ka ʻōlelo aʻoaʻo e pale aku i ka hiki ʻana o nā pilikia pilikia.