He lapaʻau no ka ʻeke a me nā hui pū!!!

He lapaʻau no ka ʻeke a me nā hui pū!!!

Ua hōʻea kekahi hui ʻepekema e ʻimi nei i nā lāʻau lapaʻau hou no ka osteoarthritis o ka lima i kahi holomua hou i ka wā o ka hoʻāʻo ʻana i kahi lāʻau lapaʻau i kūkulu mua ʻia e mālama i ka haki a me psoriasis.

Ua hiki i nā kānaka ʻepekema ke ʻike e hiki i ka lāʻau lapaʻau ke pale i ka ulu ʻana o ka osteoarthritis o ka lima i nā hiʻohiʻona holoholona, ​​​​a ke hana nei lākou i nā kānaka e hōʻoia i kona hiki ke ʻano he lāʻau lapaʻau hou, e like me ka mea i paʻi ʻia e New Atlas. ka puke pai Science Translational Medicine.

ʻakika retinoic

Ua alakaʻi ʻia ka noiʻi e nā kānaka ʻepekema ma ke Kulanui o Oxford, nāna i hoʻomaka e aʻo i nā ʻano like ʻole i loko o kahi gene i kapa ʻia ʻo ALDH1A2 i hoʻopili ʻia i ka lima koʻikoʻi OA. Ua hōʻoia ka poʻe noiʻi i kēia loulou ma ke kiʻi ʻana i ka ʻikepili mai ka UK Biobank Study, a laila loaʻa ka cartilage articular mai 33 mau maʻi OA i ka wā e hana ana lākou.

Ua aʻo pū ʻia kēia mau laʻana ma ka ʻaoʻao o nā hiʻohiʻona hoʻokolohua, i hiki ai i ka hui ke ʻike i kahi molela kikoʻī i haʻahaʻa loa i nā poʻe kiʻekiʻe. Kapa ʻia ka mole he waikawa retinoic, a ua hana ʻia e ka gene ALDH1A2. Ma o ka RNA sequencing, ua hiki i nā mea noiʻi ke ʻike i ka pilina ma waena o nā ʻano genetic, haʻahaʻa retinoic acid, a me ka mumū i ʻike ʻia ma OA.

ʻAne a me psoriasis

A laila huli nā mea noiʻi i kahi lāʻau lapaʻau i kapa ʻia ʻo Talarozole, i hoʻomohala ʻia e kāohi i ka metabolism o ka waika retinoic e mālama ai i ka haki, psoriasis a me nā kūlana ʻili pili. Ke hoʻohana ʻia i loko o nā hui kuli o nā ʻiole, ua hiki i ka lāʻau lapaʻau ke hōʻemi i ka ʻeha cartilage a me ka mumū ma hope o ʻeono hola. Hoʻopili hou ʻia nā hopena i nā hui ex vivo porcine.

Osteoporosis a me ka eha mau

Ua ʻōlelo ʻo Dr Neha Essar-Brown, ka mea kākau kumu o ka noiʻi a me ka Luna Hoʻokele o ka Health Research ma ke Kulanui o Oxford: "Aia nō ke aʻo ʻana i ka wā mua, akā me kēia mau hopena hōʻeuʻeu, ua kokoke mākou i ka hiki ke hoʻomohala. he papa hou o ka hoʻololi ʻana i nā lāʻau lapaʻau no ka mālama ʻana i ka osteoporosis.

No ka loaʻa ʻana o ka talarozole i kahi ʻōlelo palekana palekana i nā kānaka, ke kau nei nā kānaka ʻepekema i nā manaʻolana kiʻekiʻe no kahi ala maʻalahi i ka hoʻohana ʻana i ka lāʻau lapaʻau. Ua alakaʻi lākou i kahi haʻawina hōʻoia-o-manaʻo liʻiliʻi e ʻike inā hiki ke hana hou ʻia kēia mau hopena mua, e waiho ana i ke kumu no kahi ala lapaʻau hou iā OA.

nā pahuhopu olaola

Eia kekahi, ua hoʻohui ʻo Kauka Essar-Brown, "Aia kahi koi wikiwiki no nā lāʻau lapaʻau hoʻololi i ka maʻi i hoʻolālā ʻia e pale a hoʻohuli paha i nā hōʻailona ʻeha o ka maʻi rumatika. Hōʻike kēia haʻawina i kahi ʻike hou o nā kumu o ka osteoarthritis o ka lima, hiki ke alakaʻi i ka ʻike ʻana i nā pahuhopu olaola hou no ka hana ʻana i ka hiki ʻana o OA. "