Kev kuaj ntshav qab zib nephropathy ua ntej nws tshwm sim

Kev kuaj ntshav qab zib nephropathy ua ntej nws tshwm sim

Cov kws tshawb fawb tau tsim cov txheej txheem uas siv cov cim caj ces los kwv yees seb tus neeg mob ntshav qab zib hom 2 puas yuav tsim kab mob raum xyoo ua ntej, uas tuaj yeem muab txoj hauv kev los kuaj xyuas thiab kho tus mob tiv thaiv kab mob no. Thaum ntxov, raws li qhov tau tshaj tawm los ntawm New Atlas lub vev xaib, hais txog phau ntawv xov xwm Nature Communications.

Raws li Lub Koom Haum Saib Xyuas Kev Noj Qab Haus Huv Ntiaj Teb, tus naj npawb ntawm cov neeg mob ntshav qab zib hom 2 thoob ntiaj teb tau nce los ntawm 108 lab hauv 1980 txog 422 lab hauv 2014. Ib qho teeb meem ntawm ntshav qab zib yog kab mob raum, tseem hu ua mob ntshav qab zib nephropathy.

Ib qho kev kho mob tseem ceeb

Sij hawm dhau mus, cov ntshav qab zib siab hauv cov neeg mob ntshav qab zib ua rau cov khoom lim dej zoo hauv lub raum, ua rau lawv tsis ua haujlwm zoo kom tshem tawm cov khoom pov tseg ntawm cov ntshav thiab rov qab cov ntshav huv mus rau hauv cov hlab ntsha. Nws tsis yog kho tau kev puas tsuaj uas thaum kawg ua rau lub raum tsis ua haujlwm, uas yuav tsum tau lim ntshav lossis hloov lub raum.

Cov kws tshawb fawb los ntawm University of Hong Kong, koom tes nrog cov kws tshawb fawb los ntawm US-based non-profit Medical tshawb fawb lub koom haum Sanford Burnham Prebys, tau tsim cov txheej txheem uas tuaj yeem kwv yees seb tus neeg mob ntshav qab zib hom 2 puas yuav mob raum.

Tsis tas li ntawd, tus kws tshawb fawb Ronald Ma tau hais tias, "Muaj kev vam meej hauv kev txhim kho kev kho mob raum rau cov neeg mob ntshav qab zib. Txawm li cas los xij, nws tuaj yeem nyuaj rau kev ntsuas tus neeg mob txoj kev pheej hmoo ntawm kev tsim kab mob raum raws li kev kho mob ib leeg, yog li kev txheeb xyuas cov neeg muaj feem pheej hmoo ntawm kev mob ntshav qab zib raum yog qhov tseem ceeb hauv kev kho mob. "

DNA methylation

Cov kws tshawb fawb tau siv DNA methylation, cov txheej txheem lom neeg uas muaj methyl pawg ntxiv rau DNA molecule, uas yog ib txoj hauv kev uas cov hlwb tuaj yeem tswj tau cov noob caj noob ces txhua lub sijhawm thiab tuaj yeem ntsuas tau yooj yim nrog kev kuaj ntshav.

epigenetic qhia

DNA methylation yog ib qho kev hloov pauv (genetic) cuam tshuam nrog mob qog noj ntshav thiab lwm yam kab mob, xws li kab mob plawv. Muaj kev sim ua dhau los txhawm rau txheeb xyuas tus biomarker uas tuaj yeem kwv yees kab mob ntshav qab zib raum. Thaum cov kev tshawb fawb genome-wide koom haum (GWAS) tau muaj qee qhov kev vam meej hauv kev txheeb xyuas cov cim caj ces ntawm hom 2 mob ntshav qab zib, cov cim epigenetic xws li methylation tau xav tias yuav muab txoj hauv kev los ntes cov kev cuam tshuam ntawm caj ces thiab ib puag ncig.

pawg neeg sib txawv

Cov kws tshawb nrhiav tau siv DNA methylation ua tus cim qhia lawv cov qauv kev suav los kwv yees lub raum ua haujlwm, siv cov ntaub ntawv los ntawm 1271 cov neeg mob ntshav qab zib hom 2 hauv Hong Kong Diabetes Registry. Cov kws tshawb fawb kuj tau sim cov qauv ntawm ib pawg ntawm 326 Asmeskas cov neeg mob ntshav qab zib hom 2, nrog rau lub hom phiaj ntawm kev txheeb xyuas tias tus qauv tuaj yeem kwv yees kab mob raum hauv ntau haiv neeg.

rau xyoo tom ntej

"Lub algorithm tuaj yeem siv cov cim methylation los ntawm cov qauv ntshav los kwv yees ob lub raum ua haujlwm tam sim no thiab lub raum yuav ua haujlwm li cas xyoo tom ntej, uas txhais tau tias nws tuaj yeem siv tau yooj yim nrog rau cov txheej txheem uas twb muaj lawm los ntsuas tus neeg mob txoj kev pheej hmoo ntawm tus kab mob," Kevin Yip hais. , tus kws sau ntawv ntawm kev tshawb fawb. ob lub raum. "

Thaum cov kws tshawb fawb tab tom ua haujlwm los txhim kho cov txheej txheem, lawv npaj yuav nthuav nws mus rau lwm cov ntaub ntawv uas tuaj yeem txhim kho nws lub peev xwm los kwv yees lwm yam kev noj qab haus huv ntsig txog ntshav qab zib.

Maguy Farah lub horoscope twv ua ntej rau xyoo 2023