Thaum kawg.. Cov tshuaj tiv thaiv omicron thiab corona mutant

Ib pab pawg kws tshawb fawb thoob ntiaj teb tau txheeb xyuas cov tshuaj tiv thaiv kab mob uas ua rau cov kab mob Omicron thiab lwm yam hloov pauv ntawm tus mob coronavirus; Cov tshuaj tiv thaiv kab mob no tsom rau thaj chaw ntawm tus kab mob cov kab mob sib kis (spike) uas tseem ceeb tsis hloov pauv raws li cov kab mob hloov pauv.
Los ntawm kev txheeb xyuas lub hom phiaj ntawm cov "ntau qhov nruab nrab" cov tshuaj tiv thaiv kab mob ntawm cov protein ntau, nws tuaj yeem tsim cov tshuaj tiv thaiv thiab tshuaj tiv thaiv kab mob uas yuav ua tau zoo; Tsis yog tsuas yog tawm tsam omicron variant tab sis kuj tawm tsam lwm yam kev hloov pauv uas yuav tshwm sim yav tom ntej, piav qhia David Weissler, tus kws tshawb fawb ntawm Howard Hughes Medical Institute thiab tus kws tshaj lij ntawm biochemistry ntawm University of Washington Tsev Kawm Ntawv Tshuaj hauv Seattle.

Thiab qhov kev tshawb pom no qhia peb tias "los ntawm kev tsom mus rau cov tshuaj tiv thaiv kab mob uas tsom rau cov chaw khaws cia siab heev ntawm cov kab mob barbed protein, muaj ib txoj hauv kev los kov yeej cov kab mob txuas ntxiv mus," Wessler hais, hauv tsab ntawv tshaj tawm hauv University of Washington lub vev xaib.
Wessler tau coj txoj haujlwm tshawb fawb uas pom cov tshuaj tiv thaiv kab mob no, koom tes nrog pab pawg kws tshawb fawb los ntawm Switzerland, thiab luam tawm cov txiaj ntsig ntawm lawv txoj haujlwm hauv qhov kawg ntawm phau ntawv journal Nature.
Daim ntawv txheeb cais rau "Reuters" tau pom tias ntau dua 283.23 lab tus tib neeg tau kis tus kabmob coronavirus thoob ntiaj teb, thaum tag nrho cov neeg tuag los ntawm tus kabmob mus txog 5 lab thiab 716,761.
Kev kis tus kab mob no tau sau tseg hauv ntau dua 210 lub tebchaws thiab cheeb tsam txij li thawj kis tau pom nyob hauv Suav teb thaum Lub Kaum Ob Hlis 2019.
Lub omicron mutant muaj 37 qhov kev hloov pauv hauv cov nqaij pob txha uas tus kab mob no siv los txuas rau thiab ua rau tib neeg lub hlwb, muaj ntau qhov kev hloov pauv ntau yam.
"Cov lus nug tseem ceeb uas peb tau sim teb yog, 'Yuav ua li cas pab pawg ntawm kev hloov pauv hauv omicron's sparse protein cuam tshuam rau nws lub peev xwm los khi rau cov hlwb thiab tshem tawm lub cev tiv thaiv kab mob cov lus teb?" Fissler hais.
Wessler thiab cov npoj yaig kwv yees tias ntau qhov kev hloov pauv ntawm omicron tuaj yeem tshwm sim thaum muaj tus kab mob mus ntev, hauv tus neeg uas muaj lub cev tsis muaj zog, lossis vim tias tus kab mob no tau dhia ntawm tib neeg mus rau ib hom tsiaj thiab rov qab los.
Txhawm rau soj ntsuam cov txiaj ntsig ntawm cov kev hloov pauv no, cov kws tshawb fawb tau tsim tus kab mob hu ua "pseudovirus" los tsim cov proteins spiky ntawm nws qhov chaw, raws li tus mob coronaviruses ua, thiab tom qab ntawd tsim cov kab mob pseudoviruses uas muaj cov proteins spiky nrog kev hloov pauv ntawm omicron thiab cov nyob hauv thawj qhov sib txawv uas tau txheeb pom hauv kev sib kis. .
Cov kws tshawb nrhiav thawj zaug tau saib seb qhov sib txawv ntawm cov protein barbed muaj peev xwm khi rau cov protein nyob rau ntawm cov hlwb uas tus kab mob siv los txuas rau thiab nkag mus rau hauv lub cell. Cov protein no hu ua angiotensin-hloov enzyme receptor (ACE2) .

Cov kws tshawb nrhiav pom tias cov protein spiky los ntawm omicron tuaj yeem khi 2.4 npaug zoo dua li cov protein spiky pom nyob rau hauv tus kab mob sib cais thaum pib muaj kev sib kis, thiab lawv kuj pom tias omicron version tuaj yeem khi rau "ACE2" receptor. Hauv cov nas ua tau zoo, qhia tias omicron tuaj yeem kis tau ntawm tib neeg thiab lwm yam tsiaj.
Cov kws tshawb fawb tau saib seb cov tshuaj tiv thaiv kab mob zoo li cas los tawm tsam cov kab mob yav dhau los tiv thaiv tus kab mob omicron variant, thiab tau ua li ntawd siv cov tshuaj tiv thaiv kab mob los ntawm cov neeg mob uas yav dhau los muaj tus kab mob yav dhau los, tau txhaj tshuaj tiv thaiv kab mob yav dhau los, lossis tau kis kab mob ces txhaj tshuaj.. Lawv pom tias cov tshuaj tiv thaiv kab mob los ntawm cov neeg uas tau kis tus kab mob yav dhau los, thiab los ntawm cov neeg uas tau txais ib qho ntawm rau rau qhov kev siv tshuaj tiv thaiv tam sim no, txo lub peev xwm tiv thaiv kab mob.
Cov tshuaj tiv thaiv kab mob los ntawm cov neeg tau kis tus kab mob, rov zoo, thiab tom qab ntawd tau txais ob koob tshuaj tiv thaiv kuj txo lawv txoj haujlwm; Tab sis qhov txo qis tsawg dua, kwv yees li 5 zaug, uas qhia meej tias kev txhaj tshuaj tiv thaiv tom qab kis tau zoo.

Hauv ib pawg ntawm cov neeg mob lim ntshav uas tau txais koob tshuaj boost, cov neeg mob cov tshuaj tiv thaiv tau pom qhov txo qis hauv 4 npaug ntawm kev ua haujlwm nruab nrab. Weissler hais tias "Qhov no qhia tau tias koob thib peb yog pab tau tiag tiag tiv thaiv Omicron," Weissler hais.
Cov kws tshawb fawb pom tias tag nrho tab sis ib qho ntawm cov tshuaj tiv thaiv kab mob tam sim no tso cai, lossis pom zoo siv rau hauv cov neeg mob kis tus kab mob, tsis muaj kev ua haujlwm, lossis txo qis kev ua haujlwm ntawm Omicron hauv chav kuaj, thiab qhov tshwj xeeb yog cov tshuaj tiv thaiv hu ua "sotrovimab" , uas yog Nws muaj 3 mus rau XNUMX npaug ntawm kev ua haujlwm nruab nrab.
"Cov me nyuam nyob rau hauv ib qho teeb meem nyuaj" .. Yuav ua li cas tiv thaiv koj tsev neeg los ntawm Omicron?

Tus kab mob Corona "cov menyuam yaus nyob rau qhov xwm txheej nyuaj".. Koj yuav tiv thaiv koj tsev neeg li cas los ntawm Omicron?
Kev Noj Qab Haus Huv Ntiaj Teb: Tsunami nrog Corona raug mob vim Omicron thiab Delta

Tab sis thaum lawv tau sim ib pawg loj ntawm cov tshuaj tiv thaiv uas tsim tawm tsam tus kab mob yav dhau los, cov kws tshawb fawb tau txheeb xyuas 4 chav kawm ntawm cov tshuaj tiv thaiv uas khaws lawv lub peev xwm los ua kom tsis muaj zog omicron, thiab cov tswv cuab ntawm txhua chav kawm no tsom rau ib qho ntawm 4 thaj chaw tshwj xeeb ntawm cov pos hniav. pom tsis tau tsuas yog nyob rau hauv Variants ntawm tus kab mob "Corona" tshwm sim, tab sis kuj nyob rau hauv ib pab pawg neeg ntawm cov kab mob coronaviruses, hu ua "Sarbic" viruses, thiab cov chaw no tej zaum yuav pheej muaj protein ntau; Vim tias lawv ua haujlwm tseem ceeb uas cov protein poob yog tias nws hloov pauv, cov cheeb tsam no hu ua "kev txuag."
Qhov kev tshawb pom tias cov tshuaj tiv thaiv muaj peev xwm ua kom tsis zoo, los ntawm kev lees paub thaj chaw tiv thaiv hauv ntau qhov sib txawv ntawm tus kab mob, qhia tias kev tsim cov tshuaj tiv thaiv thiab tshuaj tiv thaiv kab mob uas tsom rau cov cheeb tsam no tuaj yeem ua tau zoo tiv thaiv ntau yam sib txawv uas tshwm sim los ntawm kev hloov pauv.