China na-enye ihe mgbochi n'ihu megide ụdị Corona ọhụrụ

China na-enye ihe mgbochi n'ihu megide ụdị Corona ọhụrụ

Ndị na-eme nchọpụta na China ewepụtala ọgwụ mgbochi ntụ ntụ nke a na-enye dị ka otu dose site na iku ume ozugbo na ngụgụ iji mepụta nzaghachi mgbochi dị irè. Ogwu ahụ nwere ike iweta ọtụtụ antigens, nke pụtara na otu ọgwụ nwere ike inye nchebe sara mbara megide ọtụtụ nje iku ume, dịka ihe webụsaịtị New Atlas bipụtara, na-ehota akwụkwọ akụkọ Nature.

Mmetụta dị nta na nnyefe nje

Ọbịbịa nke ọrịa COVID-19 ebutela ọganihu na teknụzụ ọgwụ mgbochi, gụnyere ọgwụ mgbochi mRNA a maara ugbu a, nke a na-enye ọtụtụ n'ime ha site na ịgbanye n'ime ogwe aka ma ọ bụ ahụ ike, na-emepụta ihe mgbochi ọchị, ya bụ gụnyere mmiri mmiri na ịdabere na ọgwụ mgbochi. wepụ nje virus mana ọ bụghị ihe mgbochi. Ọ bụ ezie na ọgwụ mgbochi injectable maka SARS-CoV-2 egosila na ọ na-ebelata oke ọrịa na ọnụ ọgụgụ ọnwụ, ha enwechaghị mmetụta na ọnụego mbufe nje a.

Mgbochi mbụ nke ọrịa

Ịmepụta nzaghachi mgbochi na anụ ahụ mucosal nke ikuku ikuku dị oke mkpa maka njikwa mmalite nke ọrịa ma nwee ike ịmepụta mgbochi siri ike na ogologo oge na nzaghachi ncheta ngwa ngwa. Iji dozie nsogbu ndị metụtara ọgwụ mgbochi injectable, ndị na-eme nchọpụta sitere na Institute of Process Engineering of the Chinese Academy of Sciences ewepụtala otu dose inhalable akọrọ ntụ ntụ.

Microspheres na nanoparticles

Usoro ogwu ohuru ohuru na-ejikọta microspheres biodegradable na protein nanoparticles, nke elu ya nwere ike igosi otutu antigens, ihe na-eme ka usoro ahụ ji alụso ọrịa ọgụ mepụta ọgwụ nje. Ọnụnọ nke ihe karịrị otu antigen na-agbasawanye nchebe nje virus nke ọgwụ mgbochi ahụ na-enye ma na-ebute nzaghachi mgbochi ọrịa. Dịka ọmụmaatụ, ọ nwere ike ịgụnye antigens sitere na ụdị SARS-CoV-2 dị iche iche ma ọ bụ SARS-CoV-2 yana ọgwụ mgbochi nje iku ume ọzọ.

Immunity nke humoral na cellular

Ozugbo a tọhapụrụ antigen nanoparticles, ngụgụ nwere ike ịmịnye ha nke ọma. N'ihi na a na-ewepụta nanoparticles na-adịgide adịgide, ha na-enye mgbochi mkparị na-adịte aka, cellular na mucosal na otu dose inhaled. Ndị nyocha ahụ nwalere ọgwụ mgbochi ntụ ntụ ha na ụmụ oke, anụmanụ ụlọ nyocha, na ihe ndị na-abụghị mmadụ, wee hụ mmepụta ihe mgbochi siri ike yana nzaghachi T-cell mpaghara, na-egosipụta nchebe nje dị irè.

Ntụgharị asụsụ ụlọ ọgwụ na-abịa n'oge adịghị anya

Wei Wei, otu n'ime ndị nyocha ahụ kwuru, "Ihe ndị dị na obere nanosystem a na-eji protein sitere n'okike na ihe polymeric akwadoro, yana ịdị irè na nchekwa nke ọgwụ mgbochi ahụ ka enyochala nke ọma na ụmụ anụmanụ na-abụghị nke mmadụ, na-egosi nnukwu ikike ya maka ntụgharị ụlọ ọgwụ," Wei Wei, otu n'ime ndị nyocha ahụ kwuru. n'ọmụmụ ihe.

Site n'ichepụta echiche, eziokwu ahụ bụ na ogwu ahụ bụ ntụ ntụ akọrọ pụtara na ọ dịghị achọ refrigeration, nke na-ebelata oke nchekwa na ụgwọ njem na-eme ka ọ dị mma maka iji mee ihe na mpaghara na-enweghị ma ọ bụ njedebe nke refrigeration.

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