Peripheral neuropathy abụghị otu ọrịa, n'ezie ọ bụ mmebi akwara nke ọtụtụ ọnọdụ kpatara. Ihe na-akpata neuropathy gụnyere:

1- Ọrịa shuga mellitus (ọrịa mamịrị neuropathy).

2- radical peripheral neuropathy n'ihi nsogbu na ọkpụkpụ azụ na vertebrae.

3- trauma ma ọ bụ nrụgide na akwara: Ọnyà, dị ka ihe mberede ụgbọ ala, ọdịda ma ọ bụ mmerụ egwuregwu, nwere ike ibelata ma ọ bụ mebie irighiri akwara. Enwere ike ịkpata ya site na mkpakọ nke irighiri akwara site na nkedo, iji crutches, ma ọ bụ mmegharị mmegharị dị ka ide ihe.

4- Enweghị vitamin: vitamin B (gụnyere B-1, B-6, na B-12), vitamin D na niacin dị mkpa maka iguzosi ike n'ezi akwara.

5- Hypothyroidism.

6- Ọgwụ: Ụfọdụ ọgwụ, karịsịa ndị a na-eji agwọ ọrịa kansa (chemotherapy), nwere ike ịkpata nke a.

7. Ọrịa autoimmune: Ndị a gụnyere Sjögren's syndrome, lupus, rheumatoid ogbu na nkwonkwo, ọrịa Guillain-Barré, ọrịa na-adịghị ala ala demyelinating polyneuritis na necrotizing vasculitis.

8- Mmanya riri ahụ.

9- Ikpughe na nsị. Ihe na-egbu egbu gụnyere ọla dị arọ ma ọ bụ kemịkalụ.

10- Ọrịa: Nke a gụnyere ụfọdụ ọrịa nje ma ọ bụ nje nke gụnyere ọrịa Lyme, herpes zoster (varicella zoster), nje Epstein-Barr, ịba ọcha n'anya C, ekpenta, diphtheria na HIV.

11- Nsogbu ketara eketa. Ọgba aghara dịka ọrịa Charcot-Marie-Tooth bụ ụdị neuropathy eketa.

12- Tumors: Ọrịa cancer (nke na-adịghị mma) na nke na-adịghị mma (nke na-adịghị mma) nwere ike imetụta irighiri akwara n'onwe ya ma ọ bụ nwee ike ịbawanye nrụgide na irighiri akwara ndị gbara ya gburugburu.

Polyneuropathy nwekwara ike ibili n'ihi ụdị ọrịa kansa ụfọdụ jikọtara ya na nzaghachi mgbochi nke ahụ.

13- Ọkpụkpụ ụmị ọkpụkpụ: myeloma n'ihi osteosclerosis, lymphoma, amyloidosis na ndị ọzọ.

14- Ọrịa ndị ọzọ: gụnyere ọrịa akụrụ, ọrịa imeju...