Nazi njira zofunika kwambiri zopewera chibayo

Nazi njira zofunika kwambiri zopewera chibayo

Zinc yapezeka kuti ndi yofunika kwambiri popewa matenda a m'mapapo mwa anthu omwe ali ndi matenda a cystic fibrosis, omwe maselo awo a chitetezo cha mthupi amatha kulimbana ndi mabakiteriya achepa chifukwa cha kusintha kwa majini komwe kumayambitsa matendawa. , kuchepetsa kutupa..

Chizindikiro cha kufa msanga

Malinga ndi tsamba la New Atlas, potchulapo magazini ya PNAS, zaka 25 zapitazo, cystic fibrosis inali chizindikiro cha kufa msanga, ndipo ngakhale kuti moyo wakhala ukuyenda bwino kuyambira pamenepo, anthu omwe ali ndi cystic fibrosis akadali pachiwopsezo cha zovuta zomwe zingachitike. mlandu.

Kusintha kwa jini ya cystic fibrosis transmembrane conductance regulator (CFTR) kumayambitsa kuchuluka kwa ntchofu m'mapapu komanso kutupa kosalongosoka kwa njira ya mpweya, zomwe zimapangitsa anthu omwe ali ndi vutoli kukhala pachiwopsezo chotenga matenda obweranso. Koma ofufuza ochokera ku yunivesite ya Queensland ku Australia apeza njira yochepetsera matenda mwa anthu omwe ali ndi cystic fibrosis, omwe amadalira zinc.

Kukana kwa maantibayotiki

"Anthu omwe ali ndi cystic fibrosis amakhala ndi vuto lotupa kwambiri m'miyoyo yawo ndipo amatha kutenga matenda opatsirana ndi mabakiteriya, koma chithandizo chobwerezabwereza ndi maantibayotiki nthawi zambiri chimayambitsa matenda osagwirizana ndi maantibayotiki," anatero Peter Sly, MD, dokotala wa ana opuma komanso kuphunzira co- wolemba. Vitality.”

Thandizo lamakono

"Machiritso amakono amatha kubwezeretsa mbali zambiri za CFTR, koma samathetsa kapena kuteteza matenda a m'mapapo, choncho pakufunika kubwezeretsa chitetezo cha mthupi," Dr. Sly anawonjezera.

Pophunzira momwe kusintha kwa CFTR kumakhudzira mphamvu ya maselo a chitetezo cha mthupi, otchedwa macrophages, kulimbana ndi mabakiteriya, ofufuzawo adatsimikiza kuti mu cystic fibrosis, macrophages a m'mapapo sangagwiritse ntchito bwino nthaka ngati antibacterial agent.

Milingo yapoizoni

Matt Sweet, wofufuza nawo pa kafukufukuyu, anati: “Njira imodzi imene maselo a phagocytic amawonongera mabakiteriya ndi kuwathira poyizoni ndi zitsulo zapoizoni monga zinki,” ponena kuti “njira ya ion CFTR ndiyofunika kwambiri pa nthaka. njira, ndiponso chifukwa chakuti sichigwira ntchito moyenera mwa anthu amene ali ndi kachilomboka.” “Ndi cystic fibrosis, mwina zingafotokoze chifukwa chake amatengeka mosavuta ndi matenda oyambitsidwa ndi mabakiteriya.”

Kukanika

Kuphatikiza pa kuzindikira kusagwira ntchito kwa zinc m'maselo, ofufuzawo adapezanso puloteni yoyendera zinc, SLC30A1, yomwe idabwezeretsa kuthekera kwa macrophages kupha mabakiteriya pakusintha kwa CFTR, kutanthauza kuti chithandizo chowonjezera cha zinc chinalinso chokwanira kubwezeretsa kupha kwa bakiteriya. macrophages m'mapapo a anthu mu vitro.

Njira yatsopano

Zotsatira zikuwonetsa kuti kubwezeretsanso kuyankha kwa poizoni wa zinc kumatha kutsatiridwa ngati njira yochiritsira yobwezeretsa chitetezo chamthupi komanso chitetezo chokwanira mwa anthu omwe ali ndi cystic fibrosis, wofufuza Sweet akufotokoza kuti cholinga chake pakali pano ndi "kupereka mapuloteni oyendera zinc ku macrophages mwa anthu. ndi cystic fibrosis poyembekezera kuti idzayambitsanso chitetezo chawo cha mthupi.” “Imachepetsa matenda.”

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