Nayi njira yothetsera kuyeretsa mitsempha popanda mankhwala

Nayi njira yothetsera kuyeretsa mitsempha popanda mankhwala

Ofufuza ochokera ku National University of Singapore apeza momwe mamolekyu a maselo ofiira a m'magazi amagwirira ntchito ndi maselo oyera a m'magazi otchedwa macrophages kuti achepetse kutupa ndi kupanga mapangidwe a mafuta pamakoma a mitsempha.

Iwo ati zomwe apezazi zimapereka chithandizo chamankhwala chodziwika bwino chomwe chingayambitse matenda amtima komanso sitiroko.

Maselo ofiira a magazi

Njira yaikulu yoperekera mpweya wochokera m’mapapo kupita ku minyewa ya thupi ndi maselo ofiira a m’magazi.

Maselo ofiira amagazi mwachibadwa amapanga mamolekyu otchedwa RBCEV extracellular vesicles panthawi ya ukalamba wa maselo, matenda, komanso chifukwa cha zovuta zachilengedwe.

Ma RBCEV vesicles amateteza ma RBC pochotsa mamolekyu owopsa, kukhudza maselo a chitetezo chamthupi, komanso kutenga nawo gawo muzotupa.

Matenda a atherosulinosis

Atherosulinosis, kuchuluka kwa mafuta, cholesterol, ndi zinthu zina m'makoma a mitsempha yanu, ndizovuta zomwe zingayambitse matenda a mtima, sitiroko, aneurysm, kapena kutsekeka kwa magazi.

Macrophages, maselo oyera a m'magazi omwe ndi "oyamba kuyankha" chitetezo chamthupi, amatenga gawo lalikulu pakukula kwa atherosulinosis mwa kudya, kudziunjikira ndikusintha lipids kukhala maselo a thovu omwe amathandizira ndikusunga kukula kwa atherosulinotic plaques.

Kulowetsedwa kwa macrophages akufa

Kafukufuku watsopanoyu adayang'ana mgwirizano wapakati pa ma RBCEV vesicles ndi maselo oyera a magazi ndi chiyembekezo chopeza njira yothetsera matenda a atherosclerosis.

Chifukwa ma RBCEV vesicles ali ndi kuchuluka kwa PS pa nembanemba yawo, ofufuzawo adatsekereza zolandilira za PS pa macrophages, zomwe zidachepetsa kwambiri kutenga.

Kuteteza ma cell ku okosijeni

Pambuyo potenga ma RBCEV vesicles, macrophages amachepetsa kuchuluka kwa mapuloteni oyambitsa kutupa ndikupanga ma enzyme apamwamba omwe amateteza maselo ku kuwonongeka kwa okosijeni komwe nthawi zambiri kumawoneka m'matenda otupa amtima. Chofunika koposa, ma RBCEV adapangitsa kuti ma macrophage asakane kukhala ma cell a thovu.

Malinga ndi nyuzipepala ya Extracellular Vesicles, ofufuzawo adatsimikiza kuti kafukufuku wowonjezera pa zotsatira za ma RBCEV vesicles pogwiritsa ntchito mitundu ya nyama ya atherosulinosis ndizotheka kupititsa patsogolo chitukuko cha nsanja yochizira iyi.

Maulosi a horoscope a Maguy Farah a chaka cha 2023