Immune hyperactivity

Kupuma pang'ono kumachitika mwa odwala mphumu chifukwa cha bronchitis. Kwenikweni, ndi chitetezo chamthupi chochulukirapo poyankha zowawa monga fumbi, utsi, kuipitsidwa kapena zolimbikitsa zina.

Ndizodabwitsa kuti kafukufuku wam'mbuyomu adayang'ana puloteni yotchedwa JAK1, yomwe imagwira ntchito yofunika kwambiri polimbikitsa mayankho a chitetezo chamthupi potumiza zizindikiro ku maselo oteteza thupi omwe amatchedwa phagocytes omwe amachotsa matupi akunja.

Koma ngakhale kufunikira kwake, JAK1 nthawi zina imatha kukhala yochulukirapo komanso kukulitsa macrophages, zomwe zimapangitsa kutupa, komwe kumatha kuwonedwa mumikhalidwe yosiyanasiyana, monga matenda a Crohn, nyamakazi ya nyamakazi ndi mphumu. Ma Janus kinase inhibitors, kapena JAK mwachidule, apezeka ngati mankhwala omwe angathe kuthana ndi izi.

molekyulu "itaconate"

Mu kafukufuku watsopano, ofufuza a University of Trinity adapeza choletsa cha JAK, chomwe chimapangidwa ndi thupi la munthu. Molekyuyo, yomwe imadziwika kuti itaconate, idapezeka kuti imagwira ntchito ngati njira yozimitsa kutupa poyika mabuleki pa macrophages ochulukirapo.

Zimagwiranso ntchito pa JAK1, ndipo machitidwe ophatikizikawa akuwoneka kuti atseka kutupa komwe kumathandizira kuthana ndi mphumu.

ziyembekezo zazikulu

Ofufuzawo adayesanso chochokera ku itaconate chotchedwa 4-OI m'mitundu ya mbewa ya mphumu yayikulu, yomwe siyimayankha pamankhwala oletsa kutupa a steroid. Molekyuyo idapezeka kuti imachepetsa kuyambitsa kwa JAK1 inhibitor ndikuchepetsa kuopsa kwa mphumu mu mbewa.

Dr Marh Runch, wofufuza wotsogolera pa kafukufukuyu, adati: "Pali chiyembekezo chachikulu kuti mankhwala atsopano opangidwa ndi itaconate akhoza kukhala ndi njira yatsopano yochizira mphumu yoopsa, komwe kumafunika chithandizo chatsopano."