Phunzirani za timadzi timene timayambitsa kufalikira kwa khansa m'magazi

Sitingathe kuwerengera zomwe zimayambitsa khansa, chifukwa ndi chemistry yomwe imakhudzidwa ndi zinthu chikwi, koma kafukufuku waposachedwapa wa ku Britain anapeza kuti hormone ya kupsinjika maganizo ya munthu kapena "cortisol" ndiyo gwero lalikulu la kulephera kwa chitetezo cha mthupi kuteteza khansa ya m'magazi. .

Kafukufukuyu adachitidwa ndi ofufuza a ku yunivesite ya Kent, ku Britain, ndipo adafalitsa zotsatira zawo, m'magazini yaposachedwa ya Cellular and Molecular Immunology.

Gululo, lotsogozedwa ndi Dr. Vadim Sumbaev, linapeza kwa nthawi yoyamba kuti maselo owopsa a myeloid leukemia amazemba chitetezo chamthupi polemba cortisol yamunthu.

Gululo, lomwe kafukufuku wawo adayang'ana zomwe zimayambitsa matendawa, adanena kuti khansa ya m'magazi imagwiritsa ntchito njira yapadera yopita patsogolo m'thupi, pogwiritsa ntchito machitidwe a thupi la munthu pofuna kuthandizira kupulumuka kwa maselo, komanso kuchepetsa ntchito za chitetezo cha mthupi cha munthu. -khansa.

Kafukufukuyu adatsimikiziranso kuti khansa ya m'magazi imagwiritsa ntchito hormone cortisol kukakamiza thupi kuti litulutse puloteni "latrophyllin 1", yomwe imatsogolera kutulutsa kwa puloteni ina yotchedwa "galectin 9" yomwe imapondereza chitetezo chamthupi cholimbana ndi khansa.

Gulu la Sumbayev, logwira ntchito ndi ofufuza ochokera ku mayunivesite awiri a ku Germany, linapeza kuti ngakhale kuti maselo oyera a magazi athanzi sakhudzidwa ndi cortisol, amatha kutulutsa mapuloteni a latrophyllin-1 pamene munthu ali ndi khansa ya m'magazi.

Kafukufukuyu adatsimikiza kuti galectin-9, komanso latrophylin-1, omwe ndi mapuloteni awiri omwe amapezeka m'madzi a m'magazi a munthu, akulonjeza zolinga za immunotherapy kuti athe kuthana ndi khansa ya myoloid m'tsogolomu.

"Kwa nthawi yoyamba, tikhoza kuzindikira njira yomwe imatithandiza m'tsogolomu kuti tipeze chithandizo chatsopano chothandizira pogwiritsa ntchito njira zotetezera thupi kuti tithane ndi khansa ya m'magazi," adatero Sumbaev.

Acute myeloid leukemia imapanga m'mafupa ndipo imatsogolera ku kuchuluka kwa maselo oyera amagazi m'magazi.

Malinga ndi kuyerekezera kwa US National Cancer Institute, pafupifupi anthu 21 a acute myeloid leukemia adzapezeka chaka chino ku United States.