Chithandizo cha ziphuphu zakumaso ndi mafupa palimodzi !!!

Chithandizo cha ziphuphu zakumaso ndi mafupa palimodzi !!!

Gulu la asayansi omwe akufunafuna mankhwala atsopano a nyamakazi ya m'manja afika pachimake chatsopano pakuyesa mankhwala omwe adapangidwa kuti azichiza ziphuphu zakumaso ndi psoriasis.

Asayansi adathanso kuzindikira kuti mankhwalawa amatha kuletsa kukula kwa osteoarthritis m'manja mwa zitsanzo za nyama za labotale, ndipo pakali pano akugwira ntchito pa anthu kuti atsimikizire kuthekera kwake ngati chithandizo chatsopano chachipatala, malinga ndi zomwe zidasindikizidwa ndi New Atlas, kutchulapo. magazini ya Science Translational Medicine.

retinoic acid

Kafukufukuyu adachitidwa ndi asayansi a ku yunivesite ya Oxford, omwe adayamba kuphunzira mitundu yosiyanasiyana ya jini yotchedwa ALDH1A2 yomwe yalumikizidwa ndi OA yamanja. Ofufuzawo adatsimikizira ulalowu potengera zomwe zidachitika ku UK Biobank Study, kenako adapeza ma cartilage kuchokera kwa odwala 33 OA pomwe amachitidwa opaleshoni.

Zitsanzozi zinaphunziridwanso pamodzi ndi zitsanzo zoyesera, zomwe zinathandiza gululo kuzindikira molekyu yeniyeni yomwe inali yochepa kwambiri mwa anthu omwe ali pachiopsezo chachikulu. Molekyuyi imatchedwa retinoic acid, ndipo imapangidwa ndi jini ya ALDH1A2. Kupyolera mu kutsatizana kwa RNA, ofufuzawo adatha kuzindikira kugwirizana pakati pa mitundu yosiyanasiyana ya majini, kutsika kwa retinoic acid, ndi kutupa komwe kumawoneka mu OA.

Ziphuphu ndi psoriasis

Ofufuzawo adatembenukira ku mankhwala otchedwa Talarozole, omwe adapangidwa kuti aletse kagayidwe ka retinoic acid kuti athetse ziphuphu, psoriasis ndi zina zapakhungu. Pogwiritsidwa ntchito m'magulu a mawondo a zitsanzo za mbewa, mankhwalawa adatha kuchepetsa kuvulala kwa cartilage ndi kutupa pambuyo pa maola asanu ndi limodzi. Zotsatira zake zidabwerezedwanso m'magulu a nkhumba a ex vivo.

Osteoporosis ndi ululu wosatha

Dr Neha Essar-Brown, wolemba nawo kafukufukuyu komanso Director of Health Research ku Oxford University, adati: "Kafukufukuyu akadali koyambirira, koma ndi zotsatira zolimbikitsazi, ndife gawo limodzi loyandikira kuti titha kukhala ndi chitukuko. gulu latsopano la mankhwala ochiritsira osteoporosis.

Chifukwa talarozole ili ndi mbiri yovomerezeka mwa anthu, asayansi ali ndi chiyembekezo chachikulu cha njira yabwino yogwiritsira ntchito kuchipatala. Iwo adachita kafukufuku wina wochepa wotsimikizira kuti awone ngati zotsatira zoyambazi zikhoza kubwerezedwa, ndikuyika maziko a njira yatsopano yochiritsira OA.

Zolinga zachilengedwe

Komanso, Dr. Essar-Brown anawonjezera kuti, “Pali kufunikira kwachangu kwa mankhwala ochizira matenda opangidwa kuti ateteze kapena kusintha zizindikiro zowawa za nyamakazi ya nyamakazi. Kafukufukuyu akuwonetsa kumvetsetsa kwatsopano zomwe zimayambitsa matenda a osteoarthritis m'manja, zomwe zingayambitse kuzindikirika kwa zolinga zatsopano zamoyo zomwe zingathandize kuti OA ifike. "