Kodi sayansi ipeza chithandizo cha autism?

Kodi sayansi ipeza chithandizo cha autism?

Kafukufuku watsopano wapeza kuti mbewa zimanyamula mabakiteriya ambiri m'matumbo awo, ndipo mabakiteriya am'matumbo amakhudza momwe ubongo wa makoswe umagwirira ntchito.

Malinga ndi zomwe zinasindikizidwa ndi "Live Science", potchula magazini ya "Nature", ofufuza ochokera ku Taiwan ndi United States adafufuza kuti adziwe momwe mabakiteriya a m'matumbo amakhudzira ntchito ya neuronal network yomwe imayambitsa mapangidwe a chikhalidwe cha anthu makamaka.

Zimadziwika kuti mbewa ikakumana ndi mbewa yomwe sinakumanepo nayo, imadumphadumpha ndevu ndikukwera pamwamba pa mnzake, monga momwe zimakhalira agalu awiri, m'malo osungiramo anthu mwachitsanzo, akapatsana moni. . Koma mbewa za labu, zomwe zilibe majeremusi komanso opanda mabakiteriya am'matumbo, awonetsedwa kuti amapewa kucheza ndi mbewa zina m'malo mwake amakhala otalikirana modabwitsa.

Kudzipatula pagulu

"Kudzipatula kwa mbewa zopanda majeremusi sichachilendo," anatero wolemba wotsogolera kafukufuku Wei Li Wu, pulofesa wothandizira pa yunivesite ya National Cheng Kung ku Taiwan komanso munthu wina wodzacheza ku Caltech. Koma iye ndi gulu lake lofufuza ankafuna kumvetsa chimene chimachititsa khalidwe losakhazikika limeneli, komanso ngati mabakiteriya a m'matumbo amakhudzadi ma neuron muubongo wa mbewa ndikuchepetsa chikhumbo cha makoswe kuti azicheza.

Wu adauza Live Science kuti nthawi yoyamba yomwe adamva kuti mabakiteriya amatha kusokoneza machitidwe a nyama, adaganiza kuti, "Zikumveka zodabwitsa koma ndi zosaneneka pang'ono," kotero iye ndi anzake adayamba kuyesa mbewa. khalidwe lachilendo la chikhalidwe cha anthu, ndi kumvetsa chifukwa chake khalidwe lachilendo chotero limatuluka.

Ofufuzawo adayerekeza zochitika zaubongo ndi machitidwe a mbewa zabwinobwino ndi magulu ena awiri: mbewa zomwe zidaleredwa m'malo osabala kuti zisakhale ndi majeremusi, ndipo mbewa zomwe zimathandizidwa ndi kuphatikiza kolimba kwa maantibayotiki amathetsa mabakiteriya am'matumbo. Zoyesererazo zidakhazikitsidwa pamalingaliro oti mbewa zopanda majeremusi zikalowa m'malo osabala, zimayamba kutenga gulu la mabakiteriya nthawi imodzi yokha; Chifukwa chake, mbewa zothandizidwa ndi maantibayotiki zinali zosiyanasiyana ndipo zimatha kugwiritsidwa ntchito poyesa kangapo.

Gululi linayika mbewa zopanda majeremusi zomwe zimathandizidwa ndi maantibayotiki m'makola okhala ndi mbewa zosadziwika kuti aziwunika momwe amachitira. Monga momwe zimayembekezeredwa, magulu onse awiri a mbewa adapewa kuyanjana ndi anthu osawadziwa. Pambuyo poyesa khalidweli, gululo lidachita zoyeserera zingapo kuti lidziwe zomwe zikuchitika muubongo wa nyama zomwe zitha kukhala chifukwa chomwe chimachititsa chidwi cha anthu.

Kuyeseraku kunaphatikizapo kafukufuku wa c-Fos, jini yomwe imagwira ntchito m'maselo a ubongo omwe amagwira ntchito. Poyerekeza ndi mbewa zabwinobwino, mbewa zomwe zimakhudzidwa ndi mabakiteriya otha zikuwonetsa kuchuluka kwa c-Fos jini m'magawo aubongo omwe amakhudzidwa ndi kupsinjika, kuphatikiza hypothalamus, amygdala ndi hippocampus.

Kuwonjezeka kumeneku kwa ntchito za ubongo kumagwirizana ndi kukwera kwa hormone yopanikizika corticosterone mu mbewa zopanda majeremusi zomwe zimathandizidwa ndi maantibayotiki, pamene kuwonjezeka komweko sikunachitike mu mbewa zokhala ndi tizilombo toyambitsa matenda. "Pambuyo pocheza, kwa mphindi zisanu zokha, mahomoni opsinjika kwambiri amatha kuzindikirika," adatero wofufuza Wu.

Kuyeseraku kunaphatikizansopo kutembenuza ma neuron muubongo wa mbewa ndikuyimitsa momwe angafune kugwiritsa ntchito mankhwala enaake, ndipo ofufuzawo adawona kuti kuzimitsa ma neuron mu mbewa zomwe zimathandizidwa ndi maantibayotiki kumabweretsa kulumikizana kwabwino kwa anthu osawadziwa, ndikutembenuzira maselowa pa mbewa zabwinobwino. kuyanjana mwadzidzidzi.

Diego Bohorquez, pulofesa ku Duke University School of Medicine yemwe amagwira ntchito mu neuroscience komanso amaphunzira kugwirizana kwa m'matumbo ndi ubongo, yemwe sanachite nawo phunziroli, adanena kuti akukayikira kuti gulu la tizilombo toyambitsa matenda timagwirira ntchito limodzi kuti tigwirizane ndi kupanga mahomoni opsinjika maganizo. Kuyeseraku kutha kuganiziridwa kuti ndi umboni wamphamvu wakuti ma virus a m'matumbo a mbewa zabwinobwino amathandizira kuti azichita zinthu ndi mbewa, pomwe mbewa zopanda majeremusi zimalimbana ndi kuchulukitsidwa kwa mahomoni opsinjika ndipo motero amakana mwayi wawo wolumikizana ndi mbewa zina.

"Funso lomwe limakhalapo mwamphamvu ndi momwe angagwiritsire ntchito matumbo a microbiome kuti 'alankhule' ku ubongo, ndipo motero amathandizira kulamulira khalidwe kuchokera pansi pamatumbo," adatero Bohorquez.

matenda a neuropsychiatric

Kafukufuku wamtunduwu tsiku lina angathandize asayansi kuchiza anthu omwe ali ndi vuto la neuropsychiatric, monga kupsinjika ndi autism spectrum disorder, Bohorquez anawonjezera, poganiza kuti zina mwazowona pa nyama zimagwiranso ntchito kwa anthu.

chithandizo cha autism

Kafukufuku wam'mbuyomu akuwonetsa kuti kupsinjika, nkhawa, ndi autism nthawi zambiri zimachitika limodzi ndi matenda am'mimba, monga kudzimbidwa ndi kutsekula m'mimba, komanso kusokoneza kwamatumbo a microbiome. Kwa zaka khumi zapitazi, Bohorques adati, asayansi akhala akufufuza kugwirizana kumeneku pakati pa matumbo ndi ubongo ndi chiyembekezo chopanga njira zatsopano zothandizira matenda otere.

Ananenanso kuti zotsatira za kafukufukuyu zitha kupititsa patsogolo kafukufuku wokhudza chitukuko chamankhwala a autism omwe amadalira matumbo a microbiome, koma ponseponse, amawunikira "zambiri za momwe majeremusiwa amakhudzira chikhalidwe cha anthu."

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