Mishonga iyi inogona kukonzera cataract

Mishonga iyi inogona kukonzera cataract

Nepo zviratidzo zvehigh cholesterol muropa zvichisimbisa kuoma kwekuona, boka revasayendisiti rakagumisa kuti varwere vane misiyano yemajini yakabatana nemishonga yema statin vane njodzi yakawedzera yekuva nekatarakiti.

Zvakamboitika kutsvagurudzo zvakawanikwa zvakaratidza kuti kune humwe humbowo hwekuti statins inogona kuwedzera njodzi yekuvandudza cataract, maererano neThe Print, ichitaura nezve Journal of the American Heart Association (JAHA).

statins chete

Nepo ongororo ichangoburwa inotaura kuti vaongorori vakawana kuti mamwe majini anoteedzera chiitiko che statins anogona zvakare akazvimirira kuwedzera njodzi yekugadzira cataract.

Vakatsanangura kuti mishonga iyi inowanzo deredza mazinga eLDL cholesterol nekudzivisa enzyme inonzi HMG-CoA-reductase (HMGCR).

Nekudaro, tsvakiridzo yesainzi yakasimbisa kuti misiyano muHMGCR gene dunhu mune yemunhu genome inokanganisa sei varwere metabolize cholesterol.

Zvakare, muongorori anotungamira wechidzidzo ichi, Muzvinafundo Jonas Jahaus, mumwe weCardiac Genetics Group paMolecular Cardiology Laboratory paDhipatimendi reBiomedical Sciences paUniversity yeCopenhagen kuDenmark, akataura kuti chidzidzo ichi hachina kukwanisa kuwana hukama pakati pezvitsva. non-statin drugs and generic drugs. Zvinoderedza lipids uye njodzi yecataracts, saka zvingangoita kuti mhedzisiro iyi ine chekuita nema statins.

Zvisinei, akasimbisa kukosha kwekubatsira kwemaitiro ekuderedza mazinga e-low-density lipoproteins muvanhu vane high cholesterol mazinga, achitsanangura kuti anodarika njodzi duku dzekugadzira cataract.

5 zvakajairika genetic variants

Vatsvakurudzi vakaongorora genetic data yevanhu vanopfuura 402,000 vanhu, vachitarisa pane zvishanu zvakambozivikanwa zvakasiyana-siyana zvemajini zvinoderedza LDL cholesterol.

Zvibodzwa zveGenetic zvakabva zvaverengerwa zvichibva pane zvakafanotsanangurwa mhedzisiro yekusiyana kwega kwega paLDL-cholesterol. Iyo genetic coding data yakabva yaongororwa kuti ione vatakuri vekuchinja kusingawanzo muHMGCR gene inonzi inotarisirwa kurasikirwa-kwe-basa mutation.

"Patinotakura kurasikirwa-kwe-basa mutation, jini kashoma kushanda," Muzvinafundo Jahaus akadaro. Kana iyo HMGCR gene isingashande, muviri haugone kugadzira puroteni iyi. Zvichitaurwa zviri nyore, kurasikirwa-kwe-basa shanduko muHMGCR gene kwakaenzana nekutora statin. "
genetic risk score

Mhedzisiro yeongororo yakaratidza kuti njodzi dzemajini nekuda kweHMGCR dzinoita kuti vanhu vawedzere kuita cataract.

Imwe neimwe 38.7 mg / dL inoderera muLDL-cholesterol neiyo genetic mamakisi yaisanganiswa ne14% yakawedzera njodzi yekuvandudza cataract uye 25% yakawedzera njodzi yekupindira kwekuvhiya.

Positive effect

Nezve mhedzisiro yakanaka, vaongorori vanoshuma kuti chidziviso chikuru chechidzidzo ndechekuti kunyangwe kutakura aya mageneti akasiyana kunoisa njodzi yehupenyu hwese yekukura cataract, njodzi iyi haifanirwe kuongororwa nenzira imwechete kune vanhu vakatanga kutora statins gare gare muhupenyu. Statins, iyo inoderedza cholesterol muropa. Kuwedzera kuongororwa kwesangano iri mune mamwe makiriniki ekuedzwa kunodiwa kusimbisa izvi zvakawanikwa.

Zvinokosha kuziva kuti kudzivirirwa kwecholesterol yakakwira uye njodzi dzazvinokonzeresa kune nzira dzinoverengeka, dzinonyanya kukosha dziri kugadzirisa mararamiro uye kurovedza muviri nguva dzose, uchiomerera kune chikafu chakakodzera, uye kwete kuputa.

Pamwe chete nekutevera nachiremba muchiitiko chekukuvara uye kuomerera kune chirevo chekurapa kudzivirira kuitika kwematambudziko ane ngozi.