Heano nzira dzakanyanya kukosha dzekudzivirira pneumonia

Heano nzira dzakanyanya kukosha dzekudzivirira pneumonia

Zinc yakaonekwa yakakosha mukudzivirira zvirwere zvemapapu muvanhu vane cystic fibrosis, avo vane masoja ekudzivirira emuviri kurwisa mabhakitiriya akadzikira nekuda kwekuchinja kwemajini kunokonzera chirwere ichi. , kuderedza kuzvimba..

Chiratidzo chekufa nguva isati yakwana

Zvinoenderana newebhusaiti yeNew Atlas, ichitaura nepepanhau rePNAS, makore makumi maviri neshanu apfuura, cystic fibrosis yaive chiratidzo chekufa kwekutanga, uye nepo tarisiro yehupenyu yakasimukira zvakanyanya kubva ipapo, vanhu vane cystic fibrosis vachiri panjodzi yekusangana nematambudziko. case.

Shanduko mucystic fibrosis transmembrane conductance regulator (CFTR) gene inokonzeresa kuwanda kwemucus mumapapu uye kusarongeka kwekuzvimba kwenzira yemhepo, zvichiita kuti vanhu vane chirwere ichi vatambudzike zvakare. Asi vaongorori vekuYunivhesiti yeQueensland kuAustralia vakabudirira kuwana nzira inogona kuderedza hutachiona muvanhu vane cystic fibrosis, iyo inovimba ne zinc.

Mishonga inorwisa mabhakitiriya

"Vanhu vane cystic fibrosis vane chirwere chinopisa zvikuru mumhepo yavo uye vanotapukirwa nehutachiona hwehutachiona, asi kudzokorora kurapwa nemishonga inorwisa mabhakitiriya kunogona kutungamirira kune zvirwere zvisingagadziriswi nemishonga inorwisa mabhakitiriya," akadaro Peter Sly, MD, chiremba wekufema kwevana uye kudzidza co- munyori. Vitality.”

Mishonga yazvino

"Mishonga yemazuva ano inogona kudzorera zvinhu zvakawanda zveCFTR, asi hazvigadzirisi kana kudzivirira zvirwere zvemapapu, saka pane chido chekudzorera simba rekudzivirira zvirwere," Dr. Sly akawedzera.

Nokudzidza kuti kuchinja kweCFTR kunokanganisa sei kukwanisa kwemasero ekudzivirira muviri, anonzi macrophages, kurwisa mabhakitiriya, vatsvakurudzi vakaona kuti mu cystic fibrosis, mapapu macrophages haakwanise kushandisa zinc zvakanaka se antibacterial agent.

Muchetura mwero

Matt Sweet, muongorori pamwe chete muongororo iyi, akati: “Imwe yenzira iyo masero ephagocytic anoparadza mabhakitiriya ndeyekuaisa muchetura nemwero ine chepfu yesimbi yakadai sezingi,” achicherechedza kuti “iyo CFTR ion channel inokosha kune zinc. nzira, uye nemhaka yokuti haishande zvakanaka muvanhu vane utachiona.” “Ne cystic fibrosis, ingatsanangura murutivi chikonzero nei vachitapurwa nyore nyore nehosha dzeutachiona.”

Dysfunction

Pamusoro pekuziva kusashanda kwe zinc mumaseru, vaongorori vakawanawo zinc yekufambisa puroteni, SLC30A1, iyo yakadzoreredza kugona kwemacrophages kuuraya mabhakitiriya mumamiriro ekuchinja kweCFTR, zvichireva kuti kurapa kwekuwedzera zinc kwaikwanawo kudzoreredza kuuraya kwebhakitiriya mukati. mapapu emunhu macrophages in vitro.

Nzira itsva

Mhedzisiro yacho inoratidza kuti kudzorera mhinduro kune zinc toxicity inogona kuteverwa senzira yekurapa yekudzoreredza immune function uye dziviriro inoshanda muvanhu vane cystic fibrosis, nemuongorori Sweet achitsanangura kuti chinangwa parizvino "kuunza zinc yekutakura protein kune macrophages muvanhu. ne cystic fibrosis netarisiro yekuti ichaita kuti immune system yavo ishande." "Inoderedza hutachiona."

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