Kuwana hukama hwepedyo pakati pehutu nehuropi

Kuwana hukama hwepedyo pakati pehutu nehuropi

Humbowo huri kukura hunoratidza kuti makumi emabhiriyoni ehutachiona hunowanzogara mudumbu - iyo inonzi gut microbiome - ine mhedzisiro inosvika pamabatiro anoita muviri wemunhu. Nharaunda yehutachiona hunogadzira mavhitamini, inobatsira kugaya chikafu, inodzivirira kukura kwebhakitiriya inokuvadza, uye inogadzirisa immune system, pakati pezvimwe zvinobatsira.

Kurapa neurodegeneration

Maererano nezvakadhindwa ne "Neuroscience News" ichitora bhuku re "Science", chidzidzo chitsva chakaitwa nevatsvakurudzi veWashington University School of Medicine muSt. Louis mu laboratory mice inoratidza kuti gut microbiome inoitawo basa guru muhutano. yehuropi hwemunhu.

Chidzidzo ichi chinowona kuti mabhakitiriya emudumbu - muchikamu nekugadzira makomisheni akadai sepfupi-cheni fatty acids - anokanganisa maitiro emasero edziviriro mumuviri wese, kusanganisira iwo ari muuropi anogona kukuvadza nhungwa dzehuropi uye kuwedzera neurodegeneration mumamiriro ezvinhu akadai sechirwere cheAlzheimer. .

Izvo zvitsva zvakawanikwa zvinovhura magonhi ekukwanisa kugadzirisazve gut microbiome senzira yekudzivirira kana kurapa neurodegeneration.

Mhedziso inoshamisa

"Takapa vechidiki mishonga inorwisa mbeva kwevhiki imwe chete, uye takaona shanduko yekusingaperi mumatumbu avo, maitiro avo ekudzivirira muviri, uye huwandu hwe neurodegeneration hunoenderana neprotein inonzi tau yavakasangana nayo vachichembera," akadaro munyori mukuru wechidzidzo ichi. Purofesa anoremekedzwa weNeuroscience, Purofesa David Holtzman. Chimwe chinoshamisa chakawanikwa ndechokuti "kushandisa gut microbiome kunogona kuva nzira yekupesvedzera uropi pasina kuisa chero chinhu zvakananga muuropi."

Humbowo huri kuunganidza hwekuti gut microbiomes yevanhu vane chirwere cheAlzheimer inogona kusiyana neyevanhu vane hutano. Asi hazvina kujeka kana misiyano iyi ndiyo honzeri kana mhedzisiro yechirwere - kana zvese zviri zviviri - uye mhedzisiro yakagadziridzwa microbiome inogona kuita pachirwere ichi.

Genetic modifications

Kuti uone kana iyo gut microbiome ichiita basa rinokonzeresa, vaongorori vakashandura gut microbiomes yemakonzo akafanirwa kukuvadzwa kwehuropi senge chirwere cheAlzheimer uye kutadza kuziva.

Mbeva dzakagadzirwa kuratidza shanduko yakashandurwa yeuropi hwemunhu protein tau, iyo inounganidza uye inokonzera neuronal kukuvara uye atrophy muhuropi hwavo nezera remwedzi ye9.

Vakaisawo mutsauko weAPOE gene yemunhu, genetic risk factor yeAlzheimer's disease.Vanhu vane kopi imwe yeAPOE4 variant vane mukana wakapetwa katatu kana kana wekubatwa nechirwere ichi pane vanhu vane musiyano weAPOE3.

Nzira itsva yekudzivirira

"Chidzidzo ichi chinogona kupa ruzivo rwakakosha rwekuti microbiome inobata sei tau-mediated neurodegeneration," akadaro Purofesa Linda McGovern, director kuUS National Institute of Neurological Disorders.

Zvakawanikwa zvinoratidza nzira nyowani yekudzivirira nekurapa zvirwere zveurourodegenerative nekugadzirisa gut microbiome nemishonga inorwisa mabhakitiriya, probiotics, chikafu chehunyanzvi, kana dzimwe nzira.

Kutanga muzera repakati

Sekudivi ravo, Prof Holtzmann vakati zvakawanikwa zvinoratidza kuti "kurapa kunogona kutangwa muvanhu vane zera repakati ivo vachiri mukuziva asi vari padhuze nekukanganisika", vachitsanangura kuti kana kurapwa kuchigona kutangwa mumhando dzemhuka dzevakuru dzinonzwa kune neurodegeneration. chirwere chisati chave pachena kwekutanga, uye kurapwa kunoratidzwa kushanda, iyi inogona kuva iyo iyo miedzo yekliniki yevanhu inogona kutanga.

Yakasimba inokurudzira zvikonzero zvezvirwere zvetsinga uye Alzheimer's