Kusvuta handicho chete chinhu chikuru mukenza yemapapu

Kusvuta handicho chete chinhu chikuru mukenza yemapapu

Zvimwe zvinosvibisa mhepo zvinoita se "muurayi akavanzika", sezvo zvichigona kukonzera huwandu hwekenza yemapapu muvanhu vasingapute, kuburikidza nemuchina wakatsanangurwa neongororo yakabudiswa neMugovera, uye kusvika pakunzwisisa kwavo i "danho rakakosha resainzi uye. nzanga,” maererano neboka renyanzvi.

Masayendisiti kubva kuFrancis Crick Institute uye University College London akatsanangura kuti zvimedu zvakanaka (zvisingasviki 2,5 microns, dhayamita yebvudzi), izvo zvinoonekwa pakati pezvikonzero zvekushanduka kwemamiriro ekunze, zvinotungamira kukuchinja kwegomarara mumaseru ekufema system.

stealth killer

Zvimedu zvakanaka mumagasi emhepo, guruva remabhureki kana utsi hunobva mufossil hunogona kufananidzwa ne "muurayi akavanzika", akadaro Charles Swanton weFrancis Crick Institute, uyo akapa mhedzisiro yeongororo iyi, iyo isati yaongororwa nevamwe vaongorori. Panguva yemusangano wepagore weEuropean Society of Medical Oncology, wakaitirwa muParis kusvika 13 Gunyana.

Kunyange Purofesa Swanton akayeuchidza kuti kukuvadza kwekusvibiswa kwemhepo kwave kuchizivikanwa kwenguva yakareba, akacherechedza kuti masayendisiti "haana chokwadi kana kana kusvibiswa uku kunokonzera zvakananga kenza yemapapu."

Vatsvagiri vakatanga kudzidza dhata pamusoro pevanhu vanopfuura zviuru mazana mana nemakumi matanhatu kubva kuEngland, South Korea neTaiwan, uye vakaratidza hukama pakati pekuratidzwa kwekuwedzera kuwanda kwezvimedu zvakanaka uye njodzi yakawedzera yegomarara remapapu.

250 samples

Nekudaro, chakanyanya kuwanikwa kuwanikwa ndiko kunzwisiswa kwemaitiro ayo izvi zvinosvibisa zvinokonzeresa kenza yemapapu kune vasiri kuputa.

Muzvidzidzo zvemurabhoritari pamakonzo, vaongorori vakaratidza kuti zvimedu zvakakonzera shanduko mumajeni maviri, anoti epidermal growth factor receptor (EGFR) neKeras (KRAS), ayo akatobatanidzwa nekenza yemapapu.

Ipapo vaongorori vakaongorora nezve 250 samples dzehutano hwemapapu emunhu anga asati ambooneswa carcinogens kubva kufodya kana kusvibiswa kwakanyanya. Kuchinja kwejene reEGFR kwakaonekwa mu18 muzana yemasampuli, uye shanduko muKRAS mu33 muzana yavo.

"zvakavanzika"

Prof Swanton vakati "kuchinja uku kunogona kunge kusina kukwana pachezvako kutungamirira kugomarara, asi kana sero rikafumurwa nekusvibiswa, rinogona kukurudzira kumwe kuita" kuzvimba. Akawedzera kuti "sero rinokonzera gomarara" kana "rine shanduko."

Swanton, anotungamira mutsigiri mukuru wechidzidzo ichi, Cancer Research UK, akati ongororo iyi "yaive decoding yemaitiro ebhaibheri ezvaive zvakavanzika."

Zvaidavirwa kuti kubatwa nezvinhu zvinokonzera kenza, zvakadai sezviya zvinokonzerwa nehutsi hwefodya kana kusvibiswa, zvinokonzera kuchinja kwemajini mumasero, zvichiita mamota uye zvichiita kuti awedzere.

Mutungamiriri weCancer Prevention Program paGustave Rossi Sozette Delalog Institute akacherechedza kuti zvakawanikwa pakudzidza i "revolutionary development", sezvo "kwakanga kusina humbowo hwekare hweiyi imwe carcinogenesis."

Uyu oncologist, uyo akapihwa basa rekukurukura nezvechidzidzo panguva yemusangano, akasimbisa kuti "idanho rakakosha resainzi", achitarisira kuti zvichave zvakadaro "kunharaunda zvakare", uye akafunga kuti "inovhura musuwo wakakura weruzivo." asiwo kudzivirira.”

Kuderedza kusvibiswa kwemhepo

Prof Swanton vakati danho rinotevera richave "kunzwisisa kuti sei mamwe masero emapapu akachinjwa achizoita gomarara mushure mekusangana nezvinosvibisa".

Vatsvakurudzi vakati wandei vakaratidza kuti chidzidzo ichi chinosimbisa kuti kuderedza kusvibiswa kwemhepo kwakakoshawo kune hutano.

"Tine sarudzo pakati pekuputa kana kwete, asi isu hatigone kusarudza mweya watinofema," Swanton akadaro. Naizvozvo idambudziko renyika yose kana tichifunga kuti nhamba yevanhu vanosangana nemwero isina kunaka yetsvina ingangowedzera nekashanu pane vaya vanoputirwa nehutsi hwefodya.”

Inopfuura 90 muzana yechiverengero chavagari vapasi chenyika inoratidzirwa kuizvo World Health Organization inorondedzera semwero yakanyanyisa yetsvina ine tunhu tuduku.