China inopa kusadzivirirwa pamberi peiyo itsva Corona musiyano

China inopa kusadzivirirwa pamberi peiyo itsva Corona musiyano

Vatsvagiri vekuChina vakagadzira mushonga wekudzivirira wehupfu unopihwa sedosi rimwe chete nekufemerwa zvakananga mumapapu kuti ibudise mhinduro inoshanda yekudzivirira. Mushonga uyu unogona kupa maantigen akawanda, zvinoreva kuti dosi rimwe chete rinogona kupa dziviriro yakafara kubva kuhutachiona hwekufema huzhinji, maererano nezvakaburitswa neNew Atlas webhusaiti, ichitaura nezve Nature magazine.

Kuderera kwekutapurirana kwehutachiona

Kuuya kwedenda reCCIDID-19 kwakonzera kufambira mberi kwehunyanzvi hwekudzivirira, kusanganisira iyo inozivikanwa ikozvino mRNA vaccines, mazhinji ayo anopihwa jekiseni muruwoko kana mhasuru, achigadzira husahwira hwemuviri, kureva kusanganisa mvura yemuviri uye kuvimba nemasoja ekudzivirira chirwere. kuderedza utachiona asi kwete kusadzivirira zvirwere. Kunyange majekiseni ekudzivirira eSARS-CoV-2 akaratidzwa kuderedza zvakanyanya kufa nekufa, ane zvishoma zvinokanganisa kutapurirana kwehutachiona.

Kukurumidza kudzora hutachiona

Kugadzira mhinduro yekudzivirira mudumbu mucosal tishu yenzira yemhepo kwakakosha pakudzora kwekutanga kwehutachiona uye inogona kuburitsa yakasimba uye inogara kwenguva refu yekudzivirira nekukurumidza nekurangarira mhinduro. Kugadzirisa matambudziko ane chekuita nejekiseni rejekiseni, vatsvakurudzi veInstitute of Process Engineering yeChinese Academy of Sciences vakagadzira imwe-dose imwe chete inofemerwa yehupfu yakaoma yekudzivirira.

Microspheres uye nanoparticles

Iyo yekuvandudza yekudzivirira yepuratifomu inosanganisa biodegradable microspheres neprotein nanoparticles, iyo pamusoro iyo inogona kuratidza akawanda maantigen, zvinhu zvinoita kuti immune system igadzire masoja ekudzivirira chirwere. Kuvapo kweanopfuura antigen imwe chete kunopamhidzira huwandu hwekudzivirira kwehutachiona hunopihwa nejekiseni uye kukonzeresa mhinduro yakafara yekudzivirira. Semuenzaniso, inogona kusanganisira maantigens kubva kune akasiyana SARS-CoV-2 strains kana SARS-CoV-2 musanganiswa neimwe yekufema hutachiona hwekudzivirira.

Humoral uye cellular immune

Kana maantigen nanoparticles asunungurwa, mapapu anogona kuatora zvakanaka. Nekuti nanoparticles inoburitswa yakachengeteka, inopa inogara kwenguva refu humoral, cellular uye mucosal immune ine imwechete inhaled dose. Vatsvakurudzi vakaedza vaccine yavo yehupfu mumakonzo, mhuka dzomurabhoritari, uye zvidzidzo zvisiri zvevanhu, uye vakacherechedza kugadzirwa kwakasimba kweantibody uye mhinduro yemunharaunda yeT-cell, ichiratidza kudzivirirwa kwehutachiona hunobudirira.

Shanduro yekiriniki iri kuuya munguva pfupi

"Zvikamu zveiyi nanosystem diki zvinoshandisa mapuroteni echisikigo uye zvakabvumidzwa zvepolymeric zvinhu, uye kushanda uye kuchengetedzeka kwejekiseni kwakadzidzwa zvakarongeka mune zvisiri zvevanhu, zvichiratidza kugona kwayo kukuru kwekushandura kwekiriniki," akadaro Wei Wei, mumwe wevaongorori. muchidzidzo.

Kubva pakuona kwekugadzira, chokwadi chokuti jekiseni ipfu yakaoma inoreva kuti haidi firiji, iyo inoderedza zvakanyanya kuchengetedza uye mari yekufambisa uye inoita kuti ive yakakodzera kushandiswa munzvimbo dzisina kana zvishoma zvigadziro zvefriji.

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