Immune hyperactivity

Kupfupika kwekufema kunoitika kune varwere vane asthma nekuda kwebronchitis. Chaizvoizvo, ndeye yakawandisa immune system mukupindura kune zvinokonzeresa seguruva, utsi, kusvibiswa kana zvimwe zvinokurudzira.

Zvinokosha kuziva kuti tsvakiridzo yapfuura yakanangana nepuroteni inonzi JAK1, iyo inoita basa rakakosha mukukurudzira mhinduro dzemuviri nekutumira masaini kumasero ekudzivirira anonzi phagocytes anobvisa miviri yekunze.

Asi zvisinei nekukosha kwayo, JAK1 dzimwe nguva inogona kuwedzeredza uye kuwedzeredza macrophages, zvichikonzera kuzvimba, izvo zvinogona kuwonekwa mumhando dzakasiyana siyana, dzakadai sechirwere cheCrohn, rheumatoid arthritis uye asthma. Janus kinase inhibitors, kana kuti JAK kwenguva pfupi, yabuda semushonga ungangoita wemamiriro aya.

molecule "itaconate"

Muchidzidzo chitsva, vaongorori veTrinity University vakaona inhibitor yeJAK, inogadzirwa nemuviri wemunhu. Iyo morekuru, inozivikanwa seitaconate, yakawanikwa ichiita senge yekudzima kuzvimba nekuisa mabhureki pane akawandisa macrophages.

Zvinoitawo kuita paJAK1, uye aya akasanganiswa mapatani anoita seanodzima kuzvimba kunobatsira kurwisa asima.

tariro huru

Vatsvakurudzi vakaedzawo itaconate yakabva kune inonzi 4-OI mumakonzo emhando dzakanyanya asthma, iyo isingapindure kune yakajairwa anti-inflammatory steroid kurapwa. Iyo molecule yakawanikwa ichideredza activation yeJAK1 inhibitor uye kuderedza kuoma kweasthma mumakonzo.

Dr Marh Runch, muongorori anotungamirira wekudzidza, akati: "Kune tarisiro huru yokuti mishonga mitsva yeitaconate inogona kuva nekwanisi senzira itsva yekurapa yekurapa asthma yakaoma, apo pane kudiwa kwekukurumidzira kwemishonga mitsva."