New Corona .. hutachiona hunobata kutevedzera, kushamisa uye zvinoshamisa

Panguva iyo nyika yese ichiri kutambura pasi pehutachiona hweCorona, nyanzvi dziri kuyedza kumhanyisa nguva kugadzirisa chakavanzika chemuvengi wevanhu, uyo abata vanhu vanopfuura mamirioni makumi mana nemana, uye akauraya vanopfuura miriyoni. sezvo yakaonekwa isingasviki gore rapfuura kekutanga muChina.

Chii chitsva nhasi chakawanikwa neongororo yakaitwa nevatsvaguri veVagelos College yeVanachiremba uye maSurgeons paColumbia University, avo vakati hutachiona hwekorona hune hunyanzvi hwekutevedzera mapuroteni ekudzivirira emunhu ane chekuita nechirwere cheCovid-19. Chidzidzo ichi chakaburitswa pawebhusaiti yejenari Cell System.

Nguva yechando yeCorona yakasviba uye tarisiro yezvakaipisisa ..

Nekuda kwake, Sagi Shapira, mubatsiri purofesa wezvirongwa zvebiology paVagelos College yeVanachiremba uye Vanovhiya paColumbia University, uye muongorori anotungamira wechidzidzo ichi, akadaro mumushumo wakaburitswa neChipiri pawebhusaiti yeyunivhesiti: "Mavhairasi anoshandisa kutevedzera nechikonzero chimwe chete nemhuka, unyengeri,” achiwedzera kuti: “Taifungidzira kuti kuzivikanwa kwakafanana neProtein utachiona Izvo zvaizotipa zviratidzo zvenzira iyo hutachiona - kusanganisira iyo novel coronavirus - inovakonzeresa. "

“Kupfuura zvataifunga”

Achishandisa macomputer emhando yepamusoro kutsvaga hutachiona hwekutevedzera achishandisa software yakafanana neyekuzivikanwa kwechiso che 7000D, Shapira nechikwata chake chekutsvagisa vakaongorora mavhairasi anopfuura zviuru zvinomwe uye mavhairasi anopfuura zviuru zvina munzvimbo dzese dzePasi uye vakaona mamiriyoni matanhatu ezviitiko zvehutachiona.

Mwana anoburitsa marapirwo ecorona, dambudziko richapera here?

Akatsanangurawo kuti “kutevedzera inzira yakapararira pakati pemavhairasi kupfuura zvataifunga.” Inoshandiswa nemhando dzose dzemavhairasi, zvisinei nekukura kweutachiona hwejenome, kuti utachiona hunoberekana sei, kana kuti hutachiwana hunobata utachiona, zvirimwa. zvipembenene kana vanhu.”

“kunyanya kuchenjera”

Akaenderera mberi achiti, “Zvisinei, mamwe marudzi emavhairasi anoshandisa kutevedzera kupfuura mamwe. Nepo papillomaviruses neretroviruses vasingazvishandise zvakanyanya, takaona kuti makoronavirus ane hungwaru, uye takaona kuti anoteedzera mapuroteni anopfuura zana nemakumi mashanu, kusanganisira mazhinji anodzora kugwamba kweropa, boka remapuroteni ekudzivirira anobatsira kunangana nehutachiona. .Zvirwere zvokuparadza,” achicherechedza kuti: “Taifunga kuti nokutevedzera simba romuviri rokuzvidzivirira pazvirwere uye kugwamba kwemapuroteni, coronavirus inogona kuita kuti gadziriro idzi dzishande zvakanyanyisa zvokonzera zvirwere zvatinoona muvarwere vane utachiona.”

Zvinokosha kuziva kuti panguva yedenda, zvakava pachena kuti varwere vazhinji vane Covid-19 vanotambura nedambudziko re coagulation uye kuti vamwe vacho vari kurapwa neanticoagulants nemishonga inomisa activation yezvekuwedzera.

Mune rimwe bepa rakasiyana rakaburitswa muNature Medicine, Columbia University vaongorori vakawana humbowo hwekuti kushanda uye genetic dysregulation yeiyo inopindirana system uye clotting mapuroteni ane chekuita nechirwere chakakomba cheCCIDID-19. The complement system, inova chikamu che immune system inosimudzira kugona kwemasoja ekudzivirira chirwere uye phagocytes kubvisa hutachiona uye masero akakuvadzwa kubva kune chipenyu. Vakaona kuti vanhu vane macular degeneration (yakabatana ne activation ye complement system) vangangofa kubva kuCOVID-19, iyo yekuwedzera uye yekuvhara majini yainyanya kushanda muvarwere vane chirwere ichi, uye kuti vanhu vane kumwe kupindirana uye kuvhara machinjiro. vangangove neizvi.Majeni kuchipatara nezvechirwere ichi zvakare.

Pamusoro pezvo, Shapira akafunga kuti kuongorora hutachiona hweprotein uye kutevedzera kunoratidza kuti kudzidza nezveiyo biology yehutachiona inogona kuve imwe nzira yekuziva kuti hutachiona hunokonzera sei chirwere uye ndiani angave ari panjodzi.

Zvinonzi kubva bepa iri rakatanga kubuda muchirimo chegore rino mune yekutanga vhezheni, vamwe vaongorori vakawanawo hukama pakati pekuwedzera kuomarara neCovid-19, uye mizhinji miedzo yekiriniki yemainhibitors ehurongwa uhu yakatangwa.