Kuvimbisa kudzidza mukurapa kwechirwere cheParkinson

Kuvimbisa kudzidza mukurapa kwechirwere cheParkinson

Vanhu vanopfuura mamiriyoni gumi pasi rose vari kurarama nePD kana kuti chirwere cheParkinson. Chirwere chisingarapike cheneurodegenerative chinoratidzwa nekudedera, kuoma kwemhasuru, kusafamba zvakanaka, uye kusarongeka uye kurongeka.

Nekudaro, chidzidzo chitsva chinoona kuti rudzi rwebhakitiriya remudumbu rinokonzeresa 'clumps' inokuvadza yemaneuron inova chiratidzo chechirwere cheParkinson.

Kunyange kuwanikwa uku kuchivhura musuwo wekuvandudzwa kwemishonga yakanangana nechirwere ichi chinopedza simba, maererano nezvakataurwa neNew Atlas paFrontiers mujenari reCellular and Infection Microbiology.

alpha-synuclein protein

Kana puroteni alpha-synuclein, iyo inonyanya kuwanikwa mumasero etsinga, inounganidza, inoumba miviri yeLewy. Kuvapo kwealpha-synuclein uye Lewy miviri muuropi uye mukati mehurongwa hwetsinga chiratidzo chechirwere cheParkinson.

Aggregating alpha syncytia yakawanikwa zvakare mudumbu, uye inofungidzirwa kuti gut-based pathogen inogona kukonzera kuunganidzwa, iyo inobva yaenda kuuropi.

zvakanyanya mukurumbira

Mukuedza kunzwisisa zviri nani zvinokonzera chirwere cheParkinson, vatsvakurudzi veYunivhesiti yeHelsinki muFinland vakaongorora basa iro rudzi rwebhakitiriya, kunyanya Desulfovibrio, inowanzonzi DSV, inogona kutamba.

Zvakakosha kuziva kuti kubatana pakati pehutachiona hweDesulfovibrio uye chirwere cheParkinson chakaongororwa muna 2021. Panguva iyoyo, vatsvakurudzi vakawana kuti bhakitiriya yakanga yakawanda muvarwere veParkinson. Vakaona kuti pakanga paine kuomarara kwezviratidzo zvakaonekwa muvarwere vaive nekuwedzera kuvaka-up kweDSV mabhakitiriya.

chaiwo marudzi

Nekudaro, muongororo ya2021, hazvina kuongororwa kuti mabhakitiriya eDSV akabatsira sei mukukura kwechirwere cheParkinson. Saka, muCaenorhabditis elegans, vaongorori vakatanga kuongorora kana DSV strains inobatsira mukuunganidzwa kwemiviri yealpha-synuclein uye nekudaro kuchirwere cheParkinson.

Uye vakapedzisa, mushure mekuedza kwavo murabhoritari, kuti mabhakitiriya eDSV kubva kuvanhu vane chirwere cheParkinson, kusiyana nevanhu vane hutano, anoita seane muchetura uye anogona kukonzera kuunganidzwa kwemiviri yealpha-synuclein, zvichiratidza kuti mhedzisiro yechidzidzo inosimbisa kukosha. basa rinoitwa nemamiriro ekunze mukukura kwehutachiona.Parkinson's disease.

Mibairo yakakosha

Muchirevo chechinyorwa, Per Saris, munyori pamwe chete wekudzidza, akati, "Zvatinowana zvakakosha, nokuti chikonzero chechirwere cheParkinson hachisati chazivikanwa pasinei nekuedza kuzviziva mumazana maviri emakore apfuura."

Akawedzera kuti, "Zvigumisiro zvinoratidza kuti mamwe mabhakitiriya eDesulfovibrio angangokonzera chirwere cheParkinson, ndiko kuti, chinonyanya kukonzerwa nemamiriro ekunze," achitsanangura kuti "kusangana kwezvakatipoteredza kune DSV mabhakitiriya anokonzera chirwere cheParkinson," achicherechedza kuti "Parkinson's". chirwere chinoguma Chete chikamu chidiki, kana chingangoita gumi kubva muzana, chemajini ari ega.

Kubvisa mabhakitiriya anokuvadza

Akatsanangurawo kuti, maererano nemigumisiro yekudzidza, "vatakuri vebhakitiriya rinokuvadza vanogona kuonekwa kubva kuDesulfovibrio. Saka, vanogona kunangwa nemaitirwo ekubvisa aya marara kubva muura, izvo zvinogona kuzorodza uye kunonotsa zviratidzo zvechirwere cheParkinson.

Zvinoratidzwa kuti zvimwe zvidzidzo zvenguva yemberi zvinogona kuratidza kusiyana pakati pematambudziko eDesulfovibrio DSV, ayo akaonekwa kune vanhu vane cerebral palsy uye zvidzidzo zvine utano.

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