Zvinoshamisa kubatana pakati pegut microbes uye sitiroko

Zvitsva zvakawanikwa kubva kuvatsvaguri pachipatara chakakurumbira cheAmerica Cleveland Clinic inoratidza, kekutanga, chinongedzo pakati pegut microbiome uye sitiroko. Vatsvakurudzi vakati iyo microbiome, inova boka rehutachiona hunogara nevanhu, inokwanisa kukanganisa kuoma kwesitiroko uye kukanganisa kwemamwe mabasa emuviri mushure mekurova. Zvakawanikwa nevatsvaguri, zvakaburitswa mujenari resainzi Cell Host and Microbe, zvinoisa hwaro hwezvingango itwa zvitsva kubatsira kurapa kana kudzivirira sitiroko.

Chidzidzo chekutsvaga chakatungamirirwa naDr. Weiwei Zhou uyeDr. Stanley Hazen Kubva kuLerner Research Institute yeCleveland Clinic. Chidzidzo chacho chakabva kune makore anopfuura gumi ekutsvakurudza kwakatungamirirwa naDkt Hazen neboka rake pamusoro pemigumisiro yegut microbiome pahutano hwemwoyo, iyo inosanganisira zvinokuvadza zve organic compound trimethylamine. NOxide, iyo inogadzirwa nekugayiwa kwehutachiona hwehutachiona mune zvimwe zvinovaka muviri zvinowanikwa munyama tsvuku uye zvimwe zvigadzirwa zvemhuka.

Hazen, sachigaro weDhipatimendi reMwoyo uye Metabolic Sayenzi uye director weCleveland Clinic Center yeMicrobiome uye Hutano Hwevanhu, vakati chidzidzo ichi chakawana kuti choline uye "trimethylamine" NOxide", inozivikanwa zviri nani neacronym TMAO"Ivo zvakakonzera kuwedzera kwekuoma kwesitiroko," achicherekedza kuti kutapurirana utachiona hunogona kugadzira. TMAO "Zvakanga zvakakwana kukonzera kuchinja kukuru mukuoma kwesitiroko."

Dr. Hazen neboka rake vakanga vamboona kuti yakakwirira ye TMAO Inogona kutungamirira kuchirwere chemwoyo. Muzvidzidzo zvekiriniki zvinosanganisira zviuru zvevarwere, boka rezvokurapa rakaratidza kuti mazinga e TMAO Muropa, inogona kubatsira kufanotaura njodzi dzenguva yemberi dzekurwiswa kwemoyo, kurohwa uye kufa, zvakawanikwa zvakadzokororwa mune zvimwe zvidzidzo pasi rese. Dr. Zhou naDr. Hazen ndivo vakatanga kuratidza, kuburikidza nezvidzidzo zvekare, kubatana pakati TMAO Ngozi yepamusoro yekuvhara ropa.

Hazen akafunga kuti chidzidzo chitsva ichi chinowedzera pane zvakawanikwa izvi, uye chinopa kekutanga humbowo hwekuti gut microbes, kunyanya kuburikidza. TMAO Kunyanya, vanogona kuva nemigumisiro yakananga mukuwedzera kuoma kwesitiroko kana kukanganisa kwebasa kunoitika mumurwere anotevera kukuvara.

Vatsvagiri vakafananidza kukuvadzwa kwehuropi mu preclinical modhi yesitiroko pakati peavo vane yakakwirira kana yakaderera mazinga e TMAOVakaona kuti vanhu vane mazinga e TMAO Iwo epamusoro-soro aive nekukuvara kwakapararira kwehuropi uye dhigirii repamusoro rekushanda, mota uye kushomeka kwekuziva mushure mekurova. Vatsvakurudzi vakaonawo kuti kuchinja kwechikafu kunoshandura mazinga emukomboni uyu, sekuderedza kudyiwa kwenyama tsvuku nemazai, kwakakanganisa kuoma kwesitiroko.

Hazen, uyo ari zvakare sachigaro weDivision of Preventive Cardiac Rehabilitation paMiller Cardiovascular and Thoracic Institute paCleveland Clinic, akatsanangura kuti kukanganiswa kwehuropi hwepashure-stroke ibasa guru kune varwere, achiwedzera kuti chidzidzo ichi chakafananidza kugona pakuita kwemabasa akasiyana-siyana pamberi uye mushure mekurova, munguva pfupi uye kwenguva refu, kunzwisisa kana choline uyeTMAO Vanokanganisa basa mushure mekurova, pamwe nekuoma kwesitiroko.

Chikwata chakaona kuti enzyme ye gut microbe yakakosha mukugadzirwa kwekomboni TMAO, akadaidzwa CutC, inogona kunge yakakonzera kuwedzera kwekuoma kwesitiroko uye kuwedzera kwemigumisiro yayo.

Nekuda kwake, Dr. Zhou vakaona kuti kunanga iyi enzyme yehutumbu inogona kunge iri "nzira inovimbisa" yekudzivirira sitiroko. "Patakaita genetically kunyaradza gut microbe gene inotungamira mukugadzirwa kweiyo enzyme," akadaro. CutCKuoma kwesitiroko kwadzikira zvikuru.”

Akatsanangura kuti tsvakiridzo irikuenderera mberi iri kutarisa mukati meiyo nzira yekurapa, pamwe nekugona kwekuchinja kwekudya kubatsira kuderedza mazinga emukomboni. TMAONokudaro, kuderedza ngozi yesitiroko. Akawedzera kuti kudya kwakapfuma munyama tsvuku kunosimudza mazinga emukomboni uyu, achiona kuti kuchinja kune mapuroteni ekudyara "kunobatsira kuderedza kugadzirwa kwekomboni iyi." TMAO".

Dr. Hazen inhengo yakasarudzwa yeUS National Academy of Medicine uye ane Jan Blixma Chair muVascular Biology uye Atherosclerosis, uye Leonard Krieger Chair muPreventive Cardiology paCleveland Clinic. Zvidzidzo zvake nezvaakawana zvine chekuita nekomboni zvakadzokororwa TMAO Kakawanda pasi rose, muedzo wakagamuchirwa TMAO Inoshandiswa zvakanyanya mumakiriniki maitiro.