Mushonga weacne nemajoini pamwe chete !!!

Mushonga weacne nemajoini pamwe chete !!!

Chikwata chemasayendisiti chiri kutsvaga marapirwo matsva eosteoarthritis yeruoko chasvika pakubudirira kutsva panguva yekuedzwa kwemushonga wakatanga kugadzirwa kurapa mburwa uye psoriasis.

Masayendisiti akakwanisawo kuona kuti mushonga uyu unogona kudzivirira kukura kweosteoarthritis yeruoko mumhando dzemhuka dzerabhoritari, uye iye zvino vari kushanda nevanhu kuti vasimbise kugona kwayo sekurapa kutsva kwekiriniki, maererano nezvakadhindwa neNew Atlas, ichitaura. magazini inonzi Science Translational Medicine.

retinoic asidhi

Tsvagiridzo iyi yakaitwa nemasaenzi epaYunivhesiti yeOxford, vakatanga kudzidza zvakasiyana-siyana mujeni rinonzi ALDH1A2 iro rakabatana neruoko rwakakomba OA. Vatsvagiri vakasimbisa chinongedzo ichi nekutora data kubva kuUK Biobank Study, uye ndokuwana articular cartilage kubva kuvarwere makumi matatu nenhatu OA pavaivhiyiwa.

Aya masampuli akadzidzwawo pamwe chete nemamodhi ekuyedza, ayo akagonesa timu kuti ione imwe morekuru yaive yakaderera muvanhu vane njodzi huru. Iyo morekuru inonzi retinoic acid, uye inogadzirwa neiyo ALDH1A2 gene. Kuburikidza neRNA kutevedzana, vaongorori vakakwanisa kuona kuwirirana pakati pemajini akasiyana, yakaderera retinoic acid, uye kuzvimba kwakaonekwa muOA.

Acne uye psoriasis

Vatsvakurudzi vakabva vatendeukira kumushonga unonzi Talarozole, wakagadzirwa kuti udzivise metabolism ye retinoic acid kurapa acne, psoriasis uye mamiriro eganda ane hukama. Payakashandiswa mumabvi emajoini emhando yemakonzo, mushonga uyu wakakwanisa kuderedza kukuvara kwekashwa uye kuzvimba mushure memaawa matanhatu. Mhedzisiro yacho yakadzokororwa zvakare mune ex vivo porcine majoini.

Osteoporosis uye kurwadziwa kusingaperi

Dr Neha Essar-Brown, munyori-mubatanidzwa wechidzidzo ichi uye Director weHealth Research paOxford University, vakati: "Chidzidzo ichi chichiri padanho rekutanga, asi nemhedzisiro iyi inokurudzira, isu tiri nhanho huru padyo nekukwanisa kusimudzira. kirasi itsva yemishonga inogadzirisa kurapa osteoporosis. uye arthritis. "

Nekuti talarozole ine chimiro chekuchengetedza chinogamuchirwa muvanhu, masayendisiti ari kuisa tariro huru yenzira yakatsetseka yekushandiswa kwekiriniki. Vakaita imwe ongororo diki yehumbowo-ye-pfungwa kuti vaone kana izvi mhedzisiro yekutanga inogona kudzokororwa, vachiisa hwaro hwenzira itsva yekurapa kuOA.

biological zvinangwa

Uyewo, Dr. Essar-Brown akawedzera kuti, “Pane kudiwa kwokukurumidzira kwemishonga yokugadzirisa zvirwere inogadzirirwa kudzivirira kana kudzosera shure zviratidzo zvinorwadza zve<em>rheumatoid arthritis. Ichi chidzidzo chinoratidza kunzwisisa kutsva kwezvinokonzeresa osteoarthritis yeruoko, izvo zvinogona kutungamirira mukuzivikanwa kwezvinangwa zvitsva zvehupenyu zvekupindira mukati mekusvika kweOA. "