Ko nanobodies ichave mhinduro kuCorona?

Muyedzo yekutanga yemananobodies akafanana nemonoclonal antibodies, asi ari madiki, akagadzikana uye akachipa kugadzira, vaongorori kubva kuAmerican University yePittsburgh Chikoro cheMishonga chakaratidza kuti nanobodies inofemerwa inonangana ne "spike" protein yehutachiona hwekorona huri kubuda. , inogona kuva Kudzivirira nekurapa chirwere chakakomba.

Mune ruzivo rwechidzidzo chakabudiswa mujenari "Science Advances", uye yakaitwa pa hamsters, vatsvakurudzi vakaratidza kuti madhasi akaderera ean aerobic nanobody anonzi Nanobody - 21 "PiN - 21", iyo inogona kufemerwa inodzivirira hamster kubva pakurasikirwa kukuru kwehuremu. uye inoderedza huwandu hwezvikamu zvehutachiona hwehutachiona mumhino, pahuro nemapapu nekamiriyoni, zvichienzaniswa nekurapa kwe placebo kunoshandisa nanobody isingakoshese maitiro ehutachiona.

Akatsanangura kuti nekushandisa inhalation therapy, iyo inogona kupihwa zvakananga kunzvimbo yehutachiona mumhepo yekufema nemapapu, tinogona kuita kuti marapirwo ashande, achiratidza kuti tariro yakakura, kunyanya mushure mekunge nanobody (PiN - 21) yasimbiswa. kuti inogona kudzivirira zvakanyanya pazvirwere zvakakomba, uye inogona kunge Inodzivirira kutapurirana kwehutachiona kubva kune mumwe munhu kuenda kune mumwe.

Vaccine ndiyo mhinduro yakanaka

Masayendisiti aifanira kukunda matambudziko mazhinji ehunyanzvi muongororo iyi.Mananoparticles anofanirwa kusvika mukati memapapu, uye twunhu tudiki twekurapwa hunofanirwa kunge hudiki zvekuti hahusangane pamwe chete uye hwakasimba zvekushingirira kudzvanyirira zvakanyanya.

PiN-21 nanobodies, iyo idiki zvakapetwa ka4 pane yakajairwa monoclonal antibodies ine kugadzikana kwakanyanya, inonyatso kuenderana nebasa iri, yakachipa zvakanyanya kugadzira, uye inogona kukurumidza kugadzirwa kuti ikurumidze kuchinjika kune morphovirus.

Mukuwedzera, vatsvakurudzi vakaratidza kuti nanobodies uye majekiseni anopindirana uye haasi kukwikwidzana, uye majekiseni anoramba ari nzira yakanakisisa yekudzivirira kupararira kwehutachiona kubva kune mumwe munhu kuenda kune mumwe.

Akatsanangura kuti nanobodies inongobatsira chete mukurapa vanhu vanenge vachirwara uye vasingakwanise kubaiwa nhomba nekuda kwezvimwe zvikonzero zvekurapwa.

Mimwe misoro:

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