Hosha yeAlzheimer yakawanikwa makore isati yaonekwa

Hosha yeAlzheimer yakawanikwa makore isati yaonekwa

Vatsvakurudzi vakakwanisa kushandisa ichangobva kugadzirwa immunofluorescence infrared sensor kuti vaone Alzheimer's disease biomarkers muropa samples makore 17 zviratidzo zvechipatara zvisati zvaonekwa, apo zvinokwanisika kuona kusaenzana mukuumbwa kwebeta-amyloid.

deposits muuropi

Sezvo hosha yeAlzheimer inoenderera mberi, kukanganiswa kweprotein yeamyloid-beta kunokonzera dhipoziti dzakasiyana muuropi, dzinodaidzwa kuti plaques, dzinogona kuonekwa nemwaranzi sensor yakagadzirwa muBochum, Germany.

"Chinangwa ndechekuona njodzi yekuva nechirwere cheAlzheimer pane imwe nguva nekuongororwa kweropa kuri nyore kunyangwe mapundu ane chepfu asati aumbwa muuropi, kuitira kuve nechokwadi chekuti kurapwa kunogona kutanga," anodaro Purofesa Klaus Gerwirt, mutungamiriri wekutanga wePRODI. Center for Protein Diagnostics paRuhr University muBochum.Nenguva chaiyo”, sechikamu chechirongwa chekutsvaga nekubatana neboka revasayendisiti paGerman Cancer Research Center muHeidelberg (DKFZ), inotungamirwa naProf Hermann Brenner.

Vatsvagiri vakaburitsa mhedzisiro yakawanikwa vachishandisa immunofluorescence infrared sensor mujenari Alzheimer's & Dementia, vachitsanangura kuti chidzidzo ichi chinotsigirwa neongororo yekuenzanisa yakaburitswa mujenari rimwechete munaKurume 2, 2022, iyo yakaitwa nevaongorori vachishandisa iyo inopindirana imwe molekuru. array tekinoroji (SIMOA).

Kukanganisa kwebeta-amyloid kuumbwa uye GFAP kusungwa

Boka revatsvakurudzi, rinotungamirirwa naKlaus Gerwirt naHermann Brenner, vakatsvaga kuti vaone kana zvaiita zvechokwadi kuwana zviratidzo zvechirwere cheAlzheimer muropa. 68 makore gare gare nepamusoro dhigirii yekururama. Sekuenzanisa, vaongorori vakaongorora mamwe ma biomarker vachishandisa tekinoroji inowirirana yeSIMOA - kunyanya iyo biomarker P-tau17, iyo parizvino iri kurongwa seanovimbisa biomarker mukwikwidzi muzvidzidzo zvakasiyana.

Zvinotoshamisa ndezvokuti, vatsvakurudzi vanoti, "takaona kuti kusanganiswa kweglial fiber protein GFAP inogona kuratidza chirwere kusvika kumakore 17 isati yasvika kuchipatara, kunyange zvazvo yakanyanya kuderera kudarika immune infrared sensor."

Asi vatsvakurudzi vakakwanisa kuwedzera kurongeka kwemuedzo muchikamu cheasymptomatic chechirwere cheAlzheimer nekubatanidza kukanganiswa kweamyloid beta formation pamwe nekugadzirisa kweGFAP.

kukuvara kusati kwaitika

Vatsvagiri veBochum vanotarisira kuti kuongororwa kwekutanga kwakavakirwa paamyloid-beta dysgenesis kuchabatsira kushandiswa kwemishonga yechirwere cheAlzheimer panguva yekutanga, zvekuti vanozove nemhedzisiro iri nani.

"Tinoronga kushandisa bvunzo yedysprotein kumisikidza nzira yekuongorora yevakuru kuti vaone njodzi yavo yedementia yeAlzheimer," anodaro Klaus Gerwirt, kuitira kuti kurapwa kutange kusati kwaitika "kukuvara kusingagadzirisike."

"Kusvika pari zvino, miedzo yakawanda yekiriniki yemishonga yeAlzheimer yakundikana, sezviri pachena nekuti bvunzo dzekuongorora plaque dzehuropi dzinoshandiswa mumiedzo hadzione chirwere ichi nenguva," Gerwirt anowedzera, achitsanangura kuti "kana zvikwangwani zvangoiswa, zvinokonzeresa kukuvadzwa kusingadzoreki. "Iri muuropi hwemurwere."

Kukurumidza uye kwakarurama kuongororwa

Mumiyedzo yakashandiswa kusvika parizvino, maplaque anogona kuwonekwa zvakananga muuropi vachishandisa yakaoma uye inodhura yePET scanning tekinoroji kana kuzivikanwa zvisina kunanga nenzira isina kuomesesa uchishandisa kusungirirwa kweprotein biomarker mucerebrospinal fluid inowanikwa nechisimba uchishandisa ELISA kana mass spectrometry.

Kupesana neyakagadziriswa plaque yekuongorora, iyo immune infrared sensor inoratidza yakare yakashata muamyloid-beta, iyo inogona kukonzera plaque kuiswa gare gare.

zviratidzo zvinokosha

Maprotein abnormalities anoita basa guru muzvirwere zvakawanda zveurourodegenerative, senge chirwere cheParkinson, chirwere cheHuntington uye ALS.

Sezvinotsanangurwa nevatsvaguri, iyo immuno-infrared sensor inogona zvakare kushandiswa musimboti kuona mamwe mapuroteni akacheneswa, akadai seTDP-43, anoitika muvarwere veALS, achicherekedza kuti sensor haiyere kuwanda kweprotein chaiyo, asi panzvimbo pezvo. Inoona kusaenzana ichishandisa masoja ekudzivirira chirwere.

Pfungwa inonyanya kukosha, Gerwirt anosimbisa, ndeyekuti "tekinoroji yepuratifomu inobvumira kusiyanisa uye kwakaringana biomarker-yakavakirwa kuongororwa mumatanho ekutanga ezvirwere zveurourodegenerative, uko chiratidzo-chinotariswa chekuongorora chirikuitwa parizvino chakaoma uye chinowanzo kanganisa."