Kubvisa kufutisa uye chirwere cheshuga

Kubvisa kufutisa uye chirwere cheshuga

Chidzidzo chitsva chinopa kujekesa kwakawanda pamusoro pebasa rinoitwa nekuzvimba mukufutisa uye kukura kwemamiriro anoenderana, sevaongorori veGerman neIrish vakaona kuti kushandura inonzi "checkpoint proteins" kana PD-L1 mu immune system inogona kudzora kuzvimba mu adipose. tishu, zvichiita kuti kuderedzwa kwakakosha mukufutisa uye chirwere cheshuga mune preclinical modhi, New Atlas yakashuma muScience Translational Medicine.

Izvi zvisati zvamboitika zvakasvikwa nemasayendisiti paUniversity Hospital Erlangen kuGermany neTrinity College muDublin, Ireland, izvo zvinoratidza kuti protein yePD-L1 inoshanda semhando ye “brake” inobatsira kudzora mafambiro emuviri, uye nechikonzero ichi. rave basa rakakosha mumunda weCancer immunotherapy.

PD-L1

Iprotein yePD-L1 inokwanisa kusunga kune zvinogamuchirwa pamasero ose anokosha eT, kudzivirira aya masero ekudzivirira zvirwere kubva pakubvisa masero ane ngozi ane PD-L1, anogona kusanganisira masero ekenza. Anticancer mishonga inonzi checkpoint inhibitors yakagadzirirwa kusunga kuPD-L1, iyo inosunungura mabhureki uye inobvumira mhondi T masero kushanda.

adipose tishu kuzvimba

Vatsvagiri vakatsvaga kudzidza zvakawanda nezve basa rePD-L1 mukudzora immune system zvine chekuita nekufutisa, uye kuti inokonzera sei kuzvimba muadipose tishu. Kuburikidza nekuedza mumakonzo, vatsvakurudzi vakatanga kuratidza kuti kuchinjwa kweprotein yePD-L1 pamasero makuru ekudzivirira muviri kunoshandura masero ekuputika mukati meadipose tissue. . Nekuongorora masamples evanhu akafuta, boka revaongorori rakakwanisawo kuona kuti shanduko idzi mukutaura kwePD-L1 mapuroteni ane hukama nehuremu hwemunhu.

Mechanism yekubvisa kufutisa

Sekudivi ravo, muongorori mukuru weongororo iyi, Dr. Christian Schwartz, vanoti nekuona nzira iyi, chikwata chevaongorori ichi chinotarisira kuita imwe tsvakiridzo kuitira kuti vagadzire nzira itsva dzekubvisa kufutisa pamwe nezvinokuvadza zvakaita seshuga, gomarara. uye chirwere chemwoyo.

"Zvino zvichave zvinonakidza kuongorora kuti mapuroteni ePD-L1 anofambiswa sei mune mamwe maseru kuitira kugadzirisa matambudziko evanhu vane kufutisa," akawedzera.