Kuonekwa kwechirwere cheshuga kubva paudiki !!

Kuonekwa kwechirwere cheshuga kubva paudiki !!

Vatsvakurudzi vakaongorora ropa revana vane genetic predisposition yekugadzira chirwere cheshuga XNUMX uye vakaona boka remapuroteni anofanotaura autoimmunity, iyo inofungidzirwa kuti inokonzera chirwere mwedzi isati yaonekwa zviratidzo, maererano neshumo rakabudiswa ne "New Atlas" webhusaiti. , vachitora mushumo. Cell Reports Medicine.

Kunzwisisa zvinokonzeresa uye michina

Muchirwere cheshuga cherudzi rwekutanga, masoja emumuviri anorwisa nekuparadza masero ebeta anobudisa insulin murwatata, chirwere chisingaperi chisingarapiki chinobata mamiriyoni evanhu pasi rose, asi zvinokonzeresa uye nzira dziri seri kwemhinduro yeautoimmune inokonzeresa hazvinzwisisiki. .

Proteomics

Mukati meproteomics, maproteomics anoshandiswa, pakati pezvimwe zvinhu, kuongorora nguva uye kupi mapuroteni anoratidzwa, anopindirana uye kuti anotora chikamu sei munzira dzemetabolic. Proteomic ongororo inogona kupa nzira yekuona chirwere biomarkers.

Mhedzisiro yekutsvagisa, yakaitwa nemasayendisiti kubva kuPacific Northwest National Laboratory (PNNL) muWashington, inoshuma mukana weiyo biomarkers inogona kuona iyo autoimmune process inotungamira kune Type 1 chirwere cheshuga.

Migumisiro inofadza

Thomas Metz, muongorori pachidzidzo ichi, akati "zvaifadza nezvebasa iri iro rinovhura musuwo wekuwana autoimmunity kare kupfuura iripo parizvino, izvo zvinopa mukana wekudzidza zvakawanda nezve izvo zvinoita kuti immune system ivhure muviri, uye miuyo yacho inogona kubatsira kunzwisisa mashandiro acho.” Basa rinoita basa mukukura kwechirwere cheshuga rinonzwisiswa zviri nani kupfuura riri kuitwa iye zvino uye rinopa zvikonzero zvinobvira nokuda kwokupindira kwokurapa.”

Chirwatata chemunhu chine marudzi matatu emasero anoburitsa mahormone, rimwe rawo masero e beta. Parizvino, hapana nzira yekuziva kana munhu ane genetically predisposed anotanga autoimmunity kune masero madiki, achiaparadza uye nekudaro achigadzira Type 1 chirwere cheshuga, sezvo kuongororwa kunowanzoitwa kana murwere achiuya kuchipatara kana kuhofisi yachiremba paanenge atove. vane chirwere cheshuga. Zviratidzo zvekukwira kweglucose muropa.

kuwanikwa nhanho

Ongororo yazvino yakaitwa muzvikamu zviviri, chekutanga chiri chikamu chekuwanikwa.Vatsvakurudzi vakaongorora ropa 2252 rakatorwa nguva dzose kubva kuvana 184 kubva pakuzvarwa kusvika pamakore matanhatu vachitora chikamu muEnvironmental Determinants of Diabetes muChidzidzo chevechidiki. Vatsvakurudzi vakaona 376 mapuroteni akachinjwa muvana vakaratidzwa kuti vane genetic predisposition kune chirwere cheshuga.

Verification stage

Nhanho yechipiri yaive nhanho yekusimbisa, umo vaongorori vakaongorora 6426 plasma samples kubva kuvana 990, vachishandisa muchina kudzidza algorithm kubatsira kugadzirisa nhamba yakakura yemasampuli, uye boka remapuroteni makumi masere nematatu anofanotaura seti yekuchinja muvana, avo vakaramba vachivandudza hutachiona hwehutachiona, vakaonekwa. Mapuroteni akawanikwa mwedzi isati yatanga zviratidzo.
Vatsvakurudzi vanoti ongororo iyi ichangotanga basa ravanotarisira kuti vachakwanisa kufungidzira kuti ndiyani achabatwa nechirwere cheshuga cherudzi rwekutanga, uye vane hurongwa hwekuenderera mberi nekuongorora ropa rakatorwa kuvana muongororo iyi kusvika vasvitsa makore gumi nemashanu ekuberekwa.

Zvakawanda zvakaitika

Kutsvakurudza kwakawanda kunodiwa kuongorora zvabuda uye kuona kana zvakawanikwa zvichishanda kumunhu wese, kwete vana chete, vakasarudzwa kubva muchidzidzo vane genetic predisposition yechirwere cheshuga.

Vatsvagiri vanoti biomarker inoona autoimmunity iri kusimbiswa uye inopa kugona kutarisa murwere nekuda kwehutano husina kunaka uye zvinotungamira mukurapwa nekukurumidza, kunyangwe zviratidzo zvisati zvaoneka.

"Panguva ino, boka rekutsvakurudza riri kuedza kunzwisisa kuti chirwere cheshuga chinogona kufanotaurwa sei," akadaro Ernesto Nakiasu, muongorori wekuongorora, achicherechedza kuti "pakupedzisira, chinangwa chichava chekudzivirira masero anokonzera insulini kubva pakuora uye nokudaro kudzivirira. chirwere cheshuga."

Maguy Farah's horoscope kufanotaura kwegore ra2023