Sayenzi inowana kumira uye kurwisa kuchembera

Sayenzi inowana kumira uye kurwisa kuchembera

Munhau dzinogona kushandura nyika yemishonga nesainzi, vaongorori veBraham Institute yeCambridge University vauya neimwe nzira itsva yekudzosa wachi mumasero eganda remunhu, kuburikidza nekuedza vachishandisa tekinoroji inovimbisa kwazvo yekusachembera.

Nepo maseru aya achishanda semaseru makore makumi matatu, akakwanisa kuchengetedza mamwe emabasa avo ehunyanzvi akawanikwa kuburikidza nehupenyu, kufambira mberi kunonakidza munharaunda iyi, maererano eLife, New Atlas yakashuma.

induced stem cells

Muna 2012, muongorori wekuJapan Shinya Yamanaka akapihwa Mubairo weNobel webasa rake mukugadzira maIPSC. Masero aya anotanga ari masero ematishu echikuru anokohwewa oiswa kumamorekuru mana anonzi Yamanaka factor, anoadzosera kumamiriro asina kukura. Saka, stem masero anogona dzidziso kukura kuita chero rudzi rwesero mumuviri.

Izvo zvakare zvakaziviswa kare kuti masayendisiti akabatsirwa kubva kuYamanaka factor tekinoroji munzira dzinoverengeka dzinonakidza, sezvo dzakasimwa mutsuro kuti dzidzorere maonero uye kugona kuona, kubata kushaya dopamine mumhando dzemhuka dzechirwere cheParkinson uye kugadzirisa tsandanyama dzemoyo dzakakuvadzwa. munguruve.

Nekudaro, iyo yakazara reprogramming process inotora mazuva makumi mashanu kuisa maseru kune Yamanaka zvinhu, nepo Prabraham Institute masayendisiti akawana kuti pane kuperevedza mukuita uku kunogona kuunza mamwe mabhenefiti akakosha kuhurongwa.

Reprogram

Kana maseru akagadziridzwa zvizere, anosiya humwe hunyanzvi hwavakagadzira panguva yekukura. Panyaya yemasero eganda, izvi zvinosanganisira kugadzira collagen kuti ishandiswe mumatendon, ligaments, uye mapfupa uye kubatsira mukupora maronda. Pfungwa iyi yaive yakavakirwa pakudzorera masero aya kumamiriro ehudiki, asi pasina kudzima zvachose kuzivikanwa kwavo.

Nzira itsva yechikwata, inonzi maturation-cross-reprogramming, inobvumirawo masero kuti aratidze Yamanaka zvinhu kwemazuva gumi nematatu chete, kubvisa shanduko dzine chokuita nezera uye kudzima kuzivikanwa, asi kwenguva pfupi. Aya masero akadzorerwa akabvumirwa kukura pasi pemamiriro ezvinhu, uye zvakare akawana zvinhu zvemasero eganda.

Nekutarisa makemikari mamaki anoumba epigenetic wachi uye mamorekuru anoratidzwa nemasero, masayendisiti akasimbisa kuti maseru akarongwa anoenderana nehunhu hwemaseru makore makumi matatu. Maseru akarongedzerwa akagadzirawo collagen yakawanda kupfuura maseru ekudzora, uye aibata zvine mutsindo mukuyedza kwemurabhoritari kwakagadzirirwa kudzokorora kuporeswa kwemaronda.

Nhanho huru mberi

Dr Diljit Gale, munyori-munyori wekudzidza, akati: "Zvigumisiro zvedu zvinomiririra danho guru mukunzwisisa kwedu kwekugadzirisa masero."

Akawedzera kuti, "Takaratidza kuti masero anogona kuvandudza pasina kurasikirwa nebasa rawo uye kuti kuberekwazve kunotsvaka kudzorera rimwe basa kumasero ekare."

Sezvineiwo, masayendisiti akawanawo kuti nzira yakagadziridzwa inoita seine anti-kuchembera mhedzisiro pamajini ane hukama nechirwere cheAlzheimer uye cataracts.

Zvinoshamisa kurapwa horizon

Muzvinafundo Wolf Rick, mumwewo munyori weongororo iyi, akati: “Basa iri rine zvarinoreva zvinofadza. Pakupedzisira, tinogona kukwanisa kuona majini anovandudza pasina kurongazve, uye takananga kune iwo majini kuderedza mhedzisiro yekuchembera. "

Akataurawo kuti "iyi nzira inozivisa zvakakosha zvakawanikwa zvinogona kuvhura kunoshamisa kwerapi horizon."