Jiil cusub oo tallaalka corona ah... ayaa cadow u beddeli doona saaxiib

Tallaalka Corona ayaa wali ku jira isha ugu sareysa ee indhaha caalamka ka dib markii tijaabooyinka jiilka soo socda ee tallaalka COVID-19 ay ka bilowdeen London, iyadoo qiyaasta ugu horreysa ee tallaalka cusub la maamulayo, kaas oo ah buufin sanka lagu buufiyo oo ay sameysay shirkadda Mareykanka ee Codagenix, xarun karantiil oo ku taal London, sida lagu sheegay waxa lagu dhawaaqay subaxnimadii Isniinta.

"Waa mid ka mid ah jiilka soo socda ee ugu horreeya, irbad-la'aan, sanka gudihiis, hal-dose, tallaallada COVID-19 ee nool ee la dhimay," Cathal Frey, maamulaha Open Orphan ee maamula tijaabooyinka, ayaa bayaan ku yiri.

Si loo gaaro xariiqda dhamaadka, tallaalku wuxuu u baahan doonaa in la caddeeyo badbaadada iyo waxtarka leh ee seddex waji, tijaabooyin tijaabo ah, nidaam qaadan kara dhowr bilood.

Laakiin tallaalkan, oo loo yaqaan COVI-VAC, wuu ka duwan yahay tallaallada hadda jira ee ganacsiga. Robert Coleman, oo ah maamulaha shirkadda Codagenix, ayaa sharaxaya in ay isticmaasho "qaab daciif ah oo fayraska ah oo aan sababi doonin jirro laakiin dhalin doona jawaab celin difaac adag."

"Taariikh ahaan, tallaallada nool ee la dhimay waxay ahaayeen kuwo aad waxtar u leh, iyagoo siinaya difaac dheer, difaac ballaaran oo caadi ahaan ku saleysan hal qiyaas," ayuu raaciyay.

Waxtarka ka hortagga isbeddelka fayraska

Isla mar ahaantaana, Coleman wuxuu yiri, "talaalada mRNA iyo VLP-ku-saleysan ee hadda jira waxay bartilmaameedsanayaan borotiinka sare, kaas oo xaddidaya tirada unugyada difaaca jirka ee la soo saari karo."

Sybil Tasker, MD, oo ah madaxa caafimaadka ee Codagenix, ayaa xusay in COVI-VAC ay wax ku ool u noqon karto la dagaallanka noocyada fayraska is-bedelka ah ee soo bixi kara mustaqbalka, ABC News ayaa werisay.

Wuxuu sii wadaa: "Tallaalka nool ee la yareeyey, COVI-VAC wuxuu leeyahay karti uu ku bixiyo jawaab celin ballaaran marka la barbar dhigo tallaallada kale ee COVID-19 ee bar-tilmaameedsada qayb ka mid ah fayraska, kuwaas oo muhiim u ah noocyada cusub ee SARS-CoV- 2 soo baxay."

Cadaw ilaa saaxiib

COVI-VAC waxaa la sameeyay iyadoo la adeegsanayo algorithm kaaso asal ahaan dib u habeeya hiddo-wadaha fayraska.

"Turjumaadda gaabis ah oo aan waxtar lahayn ee hiddo-wadaha fayrasku waxay ku soo jiidanaysaa unugga bini'aadamka ee habka Codagenix uu tixraacayo hagaajinta," Coleman ayaa sharaxay.

Waxa uu ku daray: "Waxaan galeynaa taxanaha fayraska bartilmaameedka ah algorithm-kayaga, barnaamijkuna wuxuu si dijital ah u demiyaa hidda-wadaha fayraska. Ka dib waxaynu isku dhejineynaa DNA-da u dhiganta oo ku beddelaneynaa ama gelineynaa genome ee fayraska dabiiciga ah. Tani waxay asal ahaan ka soo jeedisaa fayraska dabiiciga ah cadowga una beddelo saaxiib, taasoo ka dhigaysa mid aan waxyeello lahayn laakiin awood u leh inay dhaliso jawaab-celin difaac ballaaran."

Isticmaalka fayraska nool ee tallaalka ma aha mid cusub.Inta badan tallaallada aan helnay carruurti waxaa loo yaqaannaa tallaallada nool-yar. "Waxay keeni kartaa caabuq laakiin si daciif ah ayay u dhacdaa oo aanay jirin khatartiisa, laakiin difaacu waxa loo abuuraa si la mid ah fayraska caadiga ah," ayuu yidhi Ian Jones, borofisar cilmiga virology ka dhiga Jaamacadda Akhriska.

Waxa uu sii wadaa: "Dhibaatada ugu weyn ee taariikh ahaan waxay ahayd in samaynta taranka daciifka ah waxay u baahan tahay tijaabo iyo qalad badan, laakiin habka cusubi wuxuu awood u siinayaa daciifnimada la rabo in la helo hal tallaabo."

Sababtoo ah tallaalka Codagenix wuxuu isticmaalaa nooc daciif ah oo fayraska nool ah, waxaa jirta fursad yar oo tabaruceyaasha ay awood u yeelan doonaan inay fayraska u gudbiyaan bulshada ama xitaa ay la kulmaan cudurro. Laakin si loo yareeyo khatarahaan iman kara, tijaabooyinku waxay ka dhacayaan meel karantiil oo sugan oo ku taal bariga London.

"Waa feejignaan dheeri ah," Andrew Catchpole, oo ah madaxa sayniska ee mas'uulka ka ah tijaabooyinka, ayaa u sheegay ABC News, isagoo raaciyay "ma jiraan shuruudo sharci ah oo lagu tijaabinayo tallaalka goob karantiil."

Coleman wuxuu xusay in Codagenix "uu rabay inuu dhiso xarun bukaan-jiif, oo khibrad u leh tallaallada nool iyo fayrasyada, iyo shaybaar goobta si loo sameeyo qiimeyntii ugu horreysay ee bini'aadamka ee COVI-VAC si loogu oggolaado qiimeyn dhammaystiran oo ku saabsan badbaadada alaabta iyo kormeerka waqtiga dhabta ah ee mutadawiciinta. "

Kooxda ugu horraysa ee tabaruceyaasha qaangaarka ah ee caafimaadka qaba ayaa la siin doonaa qiyaasta iyada oo lagu shubayo sankooda, ka dibna si dhow loola socdo oo si joogto ah loo tijaabiyo. Tijaabadu waxay raaci doontaa habka qiyaasta qiyaasta caadiga ah.

xasaanad waarta

Si ka duwan tallaallada shatiga leh, Codagenix waxa ay aaminsan tahay in tallaalkiisu uu bixin karo difaac muddo dheer ah oo ka dhan ah COVID-19, oo leh hal ama laba qiyaas oo keliya oo nolosha ah, oo la mid ah tallaalka MMR ama busbuska.

Laakiin wali waa maalmo hore, oo ay caqabado hor yaalaan tallaalka cusub iyo heerar kale oo tijaabooyin caafimaad ah. "Daraasaddani waxay fududeyn doontaa u gudubka marxaladda XNUMX ee daraasadaha kiliinikada si loo tijaabiyo waxtarka," ayuu yiri sarkaalka sare ee sayniska ee tijaabooyinka.

Si kastaba ha noqotee, Codagenix wuxuu ku kalsoon yahay waxtarka tallaalkiisa, wuxuuna ka shaqeeyay waxa uu ugu yeeray "xawaaraha hillaaca" si uu u gaaro heerkan, wuxuuna la kaashaday soo saaraha ugu weyn ee tallaalka adduunka, Serum Institute of India.

Isla markii ay caddaatay in SARS-CoV-2 ay tahay dhibaato caalami ah, saynisyahannadu waxay bilaabeen inay ka shaqeeyaan sidii ay u soo saari lahaayeen tallaal nool oo la yareeyey, shirkaddu waxay tidhi. Anagoo kaashanayna saaxiibkayaga caalamiga ah, Machadka Serum ee Hindiya, waxaa naga go'an inaan u adeegno baahiyaha aan la daboolin ee ka ilaalinta COVID-19, gaar ahaan waddamada dakhligoodu yar yahay ee adduunka.

Maamulaha shirkadda Codagenix waxa uu rajaynaya in fududaynta tallaalkan marka qofka sanka lagu duro, iyo fududayntiisa wax-soo-saarka iyo gudbinta, ay door ka qaadan doonto sidii uu qayb weyn uga qaadan lahaa dagaalka lagula jiro C.