Waa kuwan siyaabaha ugu muhiimsan ee looga hortagi karo oof-wareenka

Waa kuwan siyaabaha ugu muhiimsan ee looga hortagi karo oof-wareenka

Zinc ayaa la ogaaday in ay muhiim u tahay ka hortagga caabuqyada sambabada ee dadka qaba cystic fibrosis, kuwaas oo unugyada difaaca dabiiciga ah awooddooda ay kula dagaallamaan bakteeriyada ay hoos u dhacday sababtoo ah isbeddelka hidde-side ee cudurka keena. , yaraynta caabuqa.

Tilmaame dhimasho dhicis ah

Sida laga soo xigtay website-ka New Atlas, oo soo xiganaya joornaalka PNAS, 25 sano ka hor, cystic fibrosis wuxuu ahaa tilmaame muujinaya suurtagalnimada dhimashada hore, iyo in kasta oo rajada noloshu ay si weyn u soo hagaagtay tan iyo markaas, dadka qaba cystic fibrosis waxay weli u nugul yihiin dhibaatooyinka ka dhasha. kiis.

Isbeddel ku yimaada hidda-wadaha cystic fibrosis transmembrane conductance regulator (CFTR) wuxuu keenaa xab-xab badan oo ku urursan sambabada iyo caabuqa marin hawomareenka oo habaysan, taasoo ka dhigaysa dadka xaaladan qaba inay u nugul yihiin caabuqyada soo noqnoqda. Laakiin cilmi-baarayaal ka socda Jaamacadda Queensland ee Australia ayaa ku guuleystay inay ogaadaan hab suurtagal ah oo lagu yareeyo caabuqyada dadka qaba cystic fibrosis, taas oo ku tiirsan zinc.

Iska caabbinta antibiyootiga

"Dadka qaba cystic fibrosis waxay leeyihiin xaalad barar ah oo ku jirta marinnada hawada waxayna aad ugu nugul yihiin caabuqyada bakteeriyada, laakiin daaweynta soo noqnoqda ee antibiyootiga waxay inta badan u horseedi kartaa caabuqyada antibiyootiga," ayuu yiri Peter Sly, MD, oo ah dhakhtarka neef-mareenka carruurta iyo cilmi-baarista. qoraaga. Muhiimad."

Daawaynta hadda

"Daawaynta hadda jirta waxay soo celin kartaa dhinacyo badan oo ka mid ah shaqada CFTR, laakiin ma xalliyaan ama ka hortagaan caabuqyada sambabada, sidaas darteed waxaa loo baahan yahay in dib loo soo celiyo shaqada difaaca," Dr. Sly ayaa ku daray.

Iyadoo la baranayo sida isbeddelka CFTR u saameeya awoodda unugyada difaaca jirka, oo loo yaqaan 'macrophages', si loola dagaallamo bakteeriyada, cilmi-baarayaashu waxay go'aamiyeen in cystic fibrosis, macrophages sambabada aysan si habboon u isticmaali karin zinc sida wakiilka bakteeriyada.

Heerarka sunta ah

Matt Sweet, oo ah cilmi-baare ka tirsan daraasaddan, ayaa yiri: "Mid ka mid ah siyaabaha ay unugyadu u baabi'iyaan bakteeriyada waa in lagu sumeeyo heerarka sunta ah ee biraha sida zinc," isagoo xusay in " kanaalka CFTR ion uu muhiim u yahay zinc. Jidka, iyo sababtoo ah si sax ah uguma shaqeeyo dadka cudurka qaba."

cillad

Marka lagu daro aqoonsashada cilladda zinc ee unugyada, cilmi-baarayaashu waxay sidoo kale heleen borotiinka gaadiidka zinc, SLC30A1, kaas oo dib u soo celiyay awoodda macrophages si ay u dilaan bakteeriyada marka loo eego isbeddelka CFTR, taasoo la micno ah in daaweynta zinc ee dheeriga ah ay sidoo kale ku filan tahay dib u soo celinta dilka bakteeriyada macrophages sambabada aadanaha in vitro.

Istaraatiijiyad cusub

Natiijooyinku waxay soo jeedinayaan in dib u soo celinta jawaabta sunta zinc waxaa loo raaci karaa istaraatiijiyad daweyn ah oo lagu soo celinayo shaqada difaaca iyo difaaca waxtarka leh ee dadka qaba cystic fibrosis, iyada oo cilmi-baaraha Sweet uu sharxayo in hadafku hadda yahay "in la keeno borotiinka gaadiidka zinc ee macrophages ee dadka. oo leh cystic fibrosis iyada oo la filayo in ay dib u soo celin doonto jawaab celintooda difaaca." "Waxay yaraynaysaa caabuqa."

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