Ho pepeseha ho tsoelang pele ho liphello tsa li-stimulants ho ama bokhachane !!

Ho pepeseha ho tsoelang pele ho liphello tsa li-stimulants ho ama bokhachane !!

Phuputso e ncha e hokahane ho pepesehela phthalates, sehlopha sa lik'hemik'hale, pele ho bokhachane le bophelo bo botle ba basali ba ho ba le bana. Liphetho tsa thuto li eketsa bopaki bo ntseng bo eketseha mabapi le litlamorao tse mpe tsa lik'hemik'hale tsena ka ho tseba hore na li-phthalates li fokotsa menyetla ea ho ima, ho senya lihomone tsa bohlokoa tsa ho ikatisa, ho phaella ho lisosa tse fumanoeng pele tsa ho ruruha le khatello ea oxidative, ho latela se ileng sa hatisoa. ka webosaete e Ncha ea Atlas, e qotsa Maikutlo a Bophelo ba Tikoloho. .

Sesepa le ho hlatsoa 'mele

Li-phthalates ke sehlopha sa lik'hemik'hale tse entsoeng ke motho tse atisang ho sebelisoa e le solvents, plasticizers, le stabilizers lihlahisoa tsa tlhokomelo ea botho tse kang sesepa, ho hlatsoa 'mele, litlolo tse nkhang hamonate, polisi ea manala, shampoo, gel ea moriri le moriri. Li-phthalates li boetse li fumaneha lihlahisoa tse ling tse fumanehang lapeng, joalo ka fatše ka vinyl, liphutheloana tsa polasetiki, li-hoses tsa jareteng le lintho tsa ho bapala.

Ja, noa le ho hema

Ho ea ka Litsi tsa US tsa Taolo le Thibelo ea Mafu (CDC), batho ba pepesehela phthalates ka ho ja le ho noa lijo tse amanang le lik'hemik'hale, 'me ho pepeseha ho itseng ho etsahala ka ho hema likaroloana tse tsamaeang le moea. Liphuputso li bontšitse hore ho pepesehela mefuta e meng ea phthalate ho senya tsamaiso ea endocrine le ho eketsa ho ruruha le khatello ea oxidative.

Phuputso e ncha, e entsoeng ke bo-rasaense ba Univesithing ea Massachusetts, e ile ea hlahloba kamano pakeng tsa ho pepesehela pele ho bokhachane ho phthalates le menyetla ea mosali ea ho emola le ho boloka bokhachane, le phello ea bona ho ruruha le khatello ea oxidative.

Endocrinology le tlhahlobo ea moroto

"Li-phthalates tse fumanehang hohle tse pepesehang letsatsi le leng le le leng li lebisa ho ba sitisang endocrine," ho boletse Carrie Nobles, mofuputsi ea ka sehloohong oa thuto.
Bafuputsi ba ile ba hlahloba lintlha tse fumanoeng e le karolo ea phuputso ea liphello tsa aspirin nakong ea bokhachane le pelehi, e ileng ea latela basali ba 1288 nakong ea linako tse tšeletseng tsa ho ilela khoeli ha ba ntse ba leka ho ima le ho latela basali ba ileng ba ima nakong eohle ea bokhachane. Karolelano ea lilemo tsa ba nkang karolo e ne e le lilemo tse 28. Lintlha li ile tsa lokisoa bakeng sa lilemo, palo ea boima ba 'mele, morabe/ morabe, ho tsuba koae, ho lekana, kapa palo ea makhetlo ao mosali a belehileng lesea le nang le boimana ba libeke tse 24 kapa ho feta.

lihomone tsa ho ikatisa

"Re khonne ho sheba tse ling tsa lintho tse hlahang tikolohong tse kang phthalates le hore na seo se amana joang le hore na ho nka nako e kae ho ima," Nobles o itse. Ha 'mele o senya phthalates, metabolites e ntšoa ka har'a moroto. Bafuputsi ba ile ba sekaseka metabolites tse 20 tsa phthalate le lihomone tsa ho ikatisa ka har'a lisampole tsa moroto tsa barupeluoa 'me ba lekanya maemo a serum ea protheine ea C-reactive, e leng biomarker ea ho ruruha.

Phthalate metabolites

Ka kakaretso, likhahla tsa moroto tsa pele ho bokhachane tsa metabolites tse 'maloa tsa phthalate li ne li amahanngoa le ho fokotseha ha menyetla ea bokhachane nakong ea nako e le' ngoe ea ho ilela khoeli (monyetla o nonneng), ho akarelletsa le 2-diethylhexyl-XNUMX, di-N-butyl, le benzyl-butyl metabolites. Empa ho ne ho se na likamano tse hlakileng pakeng tsa metabolites ea phthalate le kotsi ea ho lahleheloa ke bokhachane.

Ho ea ka Nobles, ho na le metsoako e meraro ea mantlha ea phthalate "e bonahalang e hokahane haholo le ho nka nako e telele ho ima: DEHP, e fumanehang lihlahisoa tsa polasetiki tsa polyvinyl chloride joalo ka lintho tsa ho bapala, thepa ea vinyl, likharetene tsa shaoara, likhomaretsi. , le liphutheloana tse ling tsa lijo, ntle le Ho chefo e bolaeang likokoanyana le litlolo. DBP e boetse e fumanoa ka setlolo sa moriri, poleiti ea manala, le litlolo tse ling, har'a lintho tse ling tsa ntlo. BzBP e fumanoa mekotleng e meng ea matsoho, mabanta le lieta, 'me ka tekanyo e fokolang lihlahisoa tse ling tsa tlhokomelo ea botho.

Estradiol e tlase

Maemo a phahameng a metabolite ea phthalate a 'nile a amahanngoa le ho fokotseha ha estradiol, hormone ea steroid e laolang nako ea ho ilela khoeli, nakong ea nako ea ho ilela khoeli,' me e 'nile ea amahanngoa le maemo a phahameng a FSH le luteinizing hormone, e sebetsang hammoho ho laola ovulation. tse phethang karolo ea bohlokoa nakong ea bokhachane ba pelehi.

Nobles o ile a re matšoao ana “ha e le hantle a hlaha ho basali ba nang le bothata ba ho se sebetse hantle ha mahe a mae, bo ka bang teng ka lilemo le ka lebaka la mabaka a mang.”

Ho ruruha le khatello ea oxidative

Bafuputsi ba boetse ba fumane hore basali ba nang le maemo a phahameng a ho pepesehela phthalates le bona ba ne ba e-na le maemo a phahameng a ho ruruha le khatello ea oxidative, e ka senyang lisele le DNA le ho baka mafu. Bafuputsi ba re ho ata ha li-phthalates ho etsa hore ho be thata ho basali ho laola ho pepeseha ha bona ho sa tsotellehe ho nka mehato e hlokahalang, joalo ka ho hlahloba li-label tsa lihlahisoa tsa bareki le ho khetha likhetho tse se nang phthalate, hobane li pepesetsoa ka litsela tse ngata, ho kenyelletsa le lerōle le tsoang. fuluru le lintho tse ling Ho tsoa linthong tsa ka tlung, ho monya letlalo la lihlahisoa tsa tlhokomelo ea motho hammoho le polisi ea manala le litlolo tse nkhang hamonate, ho pepeseha lijong ka lebaka la ho phutheloa ha lijo, ntle le ho noa mehloli ea lijo e silafetseng le metsi a nooang.

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