Mona ke tharollo ea ho hloekisa methapo ea mali ntle le meriana

Mona ke tharollo ea ho hloekisa methapo ea mali ntle le meriana

Bafuputsi ba Univesithi ea Sechaba ea Singapore ba fumane tsela eo limolek'hule tsa lisele tse khubelu tsa mali li kopanang le limolek'hule tsa lisele tse tšoeu tsa mali tse bitsoang macrophages ho fokotsa ho ruruha le ho thehoa ha mafura a mafura maboteng a methapo ea mali.

Ba boletse hore liphuputso tsa bona li fana ka phekolo e ka bang teng bakeng sa boemo bona bo tloaelehileng, bo ka bakang lefu la pelo le stroke.

Lisele tse khubelu tsa mali

Tsela e ka sehloohong ea ho isa oksijene matšoafong ho ea liseleng tsa ’mele ke lisele tse khubelu tsa mali.

Lisele tse khubelu tsa mali ka tlhaho li hlahisa limolek'hule tse bitsoang RBCEV extracellular vesicles nakong ea botsofali ba lisele, linaha tsa mafu, le ho arabela khatellong ea tikoloho.

Li-RBCEV vesicles li sireletsa li-RBC ka ho tlosa limolek'hule tse kotsi, tse amang lisele tsa 'mele, le ho kenya letsoho ts'ebetsong ea ho ruruha.

Arteriosclerosis

Atherosclerosis, ho bokellana ha mafura, k'holeseterole le lintho tse ling marakong a methapo ea hau, ke boemo bo tloaelehileng bo ka lebisang ho hlaseloa ke pelo, stroke, aneurysm kapa mali.

Macrophages, lisele tse tšoeu tsa mali tseo e leng "ba arabelang pele" tsamaisong ea 'mele ea ho itšireletsa mafung, li phetha karolo ea bohlokoa ho atherosclerosis ka ho ja, ho bokella le ho fetola lipids hore e be lisele tse foam tse tlatsetsang le ho boloka kholo ea li-atherosclerotic plaques.

Ho kenngoa ha macrophages a shoang

Phuputso e ncha e ile ea hlahloba tšebelisano pakeng tsa li-vesicles tsa RBCEV le lisele tse tšoeu tsa mali ka tšepo ea ho fumana mokhoa oa ho thibela lefu la atherosclerosis.

Hobane li-vesicles tsa RBCEV li na le bongata ba PS ka har'a lera la tsona, bafuputsi ba thibetse li-receptor tsa PS ho macrophages, e leng se ileng sa fokotsa ho amoheloa haholo.

Ho sireletsa lisele ho tsoa ho oxidation

Ka mor'a ho nka li-vesicles tsa RBCEV, li-macrophages li ile tsa fokotsa maemo a liprotheine tse thibelang ho ruruha 'me tsa hlahisa litekanyetso tse phahameng tsa enzyme e sireletsang lisele ho tsoa tšenyo ea oxidative e atisang ho bonoa mafung a ho ruruha a pelo. Habohlokoa le ho feta, li-RBCEV li entse hore li-macrophage li hanane le ho fetoha lisele tsa foam.

Ho latela koranta ea Extracellular Vesicles, bafuputsi ba hatelletse hore liphuputso tse ling mabapi le litlamorao tsa li-vesicles tsa RBCEV tse sebelisang mefuta ea liphoofolo tsa atherosclerosis li kanna tsa ntšetsa pele nts'etsopele ea sethala sena sa kalafo.

Likhakanyo tsa linaleli tsa Maguy Farah tsa selemo sa 2023