Saense e fumana ho emisa le ho loantša botsofali

Saense e fumana ho emisa le ho loantša botsofali

Litabeng tse ka fetolang lefats'e la bongaka le mahlale, bafuputsi ba Setsi sa Braham sa Univesithi ea Cambridge ba hlahisitse mokhoa o mocha oa ho khutlisetsa nako liseleng tsa letlalo la motho, ka liteko tse sebelisang theknoloji e thibelang botsofali e tšepisang haholo.

Le hoja lisele tsena li ne li sebetsa joaloka lisele tse nyenyane ka lilemo tse 30, li ile tsa khona ho boloka tse ling tsa mesebetsi ea tsona e khethehileng e fumanoeng bophelong, e leng tsoelo-pele e thabisang tšimong ena, ho latela eLife, New Atlas e tlaleha.

lisele tse bakoang

Ka 2012, mofuputsi oa Lejapane Shinya Yamanaka o ile a fuoa Khau ea Nobel bakeng sa mosebetsi oa hae oa ho hlahisa li-iPSC. Lisele tsena li qala e le lisele tsa lisele tsa batho ba baholo tse kotuloang ebe li pepesetsoa limolek’huleng tse ’nè tse bitsoang mabaka a Yamanaka, tse li khutlisetsang boemong ba ho se hōle. Ka hona, lisele tsa stem li ka fetoha mofuta ofe kapa ofe oa sele 'meleng.

Ho ile ha boela ha phatlalatsoa pejana hore bo-rasaense ba ruile molemo ho theknoloji ea Yamanaka factor ka litsela tse ngata tse thabisang, kaha li kenyelelitsoe ho mebutlanyana ho tsosolosa pono le bokhoni ba ho bona, ho phekola khaello ea dopamine mefuteng ea liphoofolo ea lefu la Parkinson le ho lokisa mesifa ea pelo e senyehileng. likolobeng.

Leha ho le joalo, ts'ebetso e feletseng ea reprogramming e nka matsatsi a ka bang 50 ho beha lisele ho lintlha tsa Yamanaka, ha bo-rasaense ba Prabraham Institute ba fumane hore ho na le bofokoli ts'ebetsong ena e ka tlisang melemo e meng ea bohlokoa kemisong.

Reprogram

Ha lisele li etsoa reprogramme e feletseng, li tlohela tse ling tsa bokhoni bo khethehileng boo li bo hlahisitseng nakong ea khōlo. Tabeng ea lisele tsa letlalo, sena se kenyelletsa ho hlahisa collagen bakeng sa tšebeliso ea li-tendon, li-ligamente le masapo le ho thusa ho folisa maqeba. Khopolo ena e ne e thehiloe ho khutlisetsa lisele tsena boemong ba bocha, empa ntle le ho hlakola boitsebiso ba tsona ka ho feletseng.

Mokhoa o mocha oa sehlopha, o bitsoang maturation-cross-reprogramming, o boetse o lumella lisele ho bonts'a lintlha tsa Yamanaka ka matsatsi a 13 feela, ho tlosa liphetoho tse amanang le lilemo le ho hlakola boitsebiso, empa ka nakoana feela. Lisele tsena tse tsosolositsoeng li ile tsa lumelloa ho hōla tlas'a maemo a tloaelehileng, 'me tsa boela tsa fumana thepa ea lisele tsa letlalo.

Ka ho sheba lik'hemik'hale tsa lik'hemik'hale tse etsang oache ea epigenetic le limolek'hule tseo lisele li li hlalosang, bo-rasaense ba tiisitse hore lisele tse hlophisitsoeng hape li lumellana le litšobotsi tsa lisele tse ka tlaase ho lilemo tse 30. Lisele tse hlophisitsoeng bocha li ile tsa boela tsa hlahisa collagen e ngata ho feta lisele tse laolang, 'me li sebetsa ka katleho litekong tsa laboratori tse etselitsoeng ho ikatisetsa ho fola ha maqeba.

Kgato e kgolo ho ya pele

Ngaka Diljit Gale, sengoli-'moho le eena oa thuto, o itse: "Liphetho tsa rona li emela mohato o moholo oa tsoelo-pele kutloisisong ea rona ea ho hlophisa bocha lisele."

O ile a phaella ka ho re, "Re bontšitse hore lisele li ka tsosolosoa ntle le ho lahleheloa ke mosebetsi le hore ho tsosolosoa ho batla ho tsosolosa mosebetsi o itseng liseleng tsa khale."

Hoa thahasellisa hore bo-rasaense ba boetse ba fumane hore mokhoa o fetotsoeng o boetse o bonahala o e-na le liphello tse thibelang botsofali ho liphatsa tsa lefutso tse amanang le lefu la Alzheimer's le cataracts.

Phekolo e makatsang ea pono

Moprofesa Wolf Rick, eo le eena e leng sengoli-’moho sa phuputso eo, o itse: “Mosebetsi ona o na le liphello tse thabisang haholo. Qetellong, re ka khona ho khetholla liphatsa tsa lefutso tse inchafatsang ntle le ho hlophisa bocha, 'me ka ho khetheha re shebane le liphatsa tsa lefutso ho fokotsa litlamorao tsa botsofali. ”

O ile a boela a bontša hore "mokhoa ona o phatlalatsa litšibollo tsa bohlokoa tse ka bulang pono e hlollang ea phekolo."