Ho se sebetse hantle ha 'mele

Ho hema ka thata ho hlaha ho bakuli ba nang le asthma ka lebaka la bronchitis. Ha e le hantle, ke sesole sa 'mele se sebetsang ka ho fetelletseng se arabelang ho li-allergen tse kang lerole, mosi, tšilafalo kapa lintho tse ling tse susumetsang.

Hoa hlokomeleha hore lipatlisiso tse fetileng li ne li tsepamisitse maikutlo ho protheine e bitsoang JAK1, e phethang karolo ea bohlokoa ho susumetsang likarabo tsa 'mele oa ho itšireletsa mafung ka ho romela melaetsa ho lisele tsa' mele tse bitsoang li-phagocyte tse felisang 'mele oa linaheng tse ling.

Empa ho sa tsotellehe bohlokoa ba eona, ka linako tse ling JAK1 e ka ba e feteletseng 'me ea etsa hore ho be le li-macrophages tse feteletseng, tse bakang ho ruruha, ho ka bonoang maemong a mangata, a kang lefu la Crohn, ramatiki ea ramatiki le asthma. Janus kinase inhibitors, kapa JAKs, e hlahile e le liphekolo tse ka bang teng bakeng sa maemo ana.

molek'hule "itaconate"

Phuputsong e ncha, bafuputsi ba Univesithi ea Trinity ba fumane inhibitor ea JAK, e hlahisoang ke 'mele oa motho. Molek'hule, e tsejoang e le itaconate, e ile ea sibolloa e sebetsa joalo ka mokhoa oa ho tima ho ruruha ka ho beha mariki holim'a li-macrophages tse sebetsang haholo.

E boetse e sebetsa ho JAK1, 'me mekhoa ena e kopantsoeng e bonahala e tima ho ruruha ho thusang ho loantša asthma.

tshepo e kgolo

Bafuputsi ba boetse ba lekile motsoako oa itaconate o bitsoang 4-OI mefuteng ea litoeba ea asthma e matla, e sa arabeleng kalafong e tloaelehileng ea anti-inflammatory steroid. Molek'hule e fumanoe e fokotsa ts'ebetso ea JAK1 inhibitor le ho fokotsa ho teba ha asthma ho litoeba.

Dr Marh Runch, mofuputsi ea ka sehloohong oa thuto, o itse: "Ho na le tšepo e kholo ea hore lithethefatsi tse ncha tse thehiloeng ho itaconate li ka ba le monyetla oa ho ba mokhoa o mocha oa phekolo ea ho phekola asthma e matla, moo ho nang le tlhokahalo e potlakileng ea phekolo e ncha."