Thuto e tšepisang ea phekolo ea lefu la Parkinson

Thuto e tšepisang ea phekolo ea lefu la Parkinson

Batho ba fetang limilione tse 10 lefatšeng ka bophara ba phela le PD kapa lefu la Parkinson. Ke lefu le sa phekoleheng la neurodegenerative le khetholloang ke ho thothomela, ho satalla mesifa, ho se sisinyehe hantle, le ho fokola ho leka-lekana le ho sebelisana hantle.

Leha ho le joalo, phuputso e ncha e fumana hore mofuta oa baktheria ea mala o baka 'li-clumps' tse senyang tsa li-neuron tseo e leng letšoao la lefu la Parkinson.

Leha tšibollo ena e bula monyetla oa nts'etsopele ea liphekolo tse lebisitsoeng bakeng sa lefu lena le fokolisang, ho latela seo Atlas e Ncha e tlalehileng ka eona ho Frontiers ho makasine ea Cellular and Infection Microbiology.

protheine ea alpha-synuclein

Ha protheine ea alpha-synuclein, eo hangata e fumanoang liseleng tsa methapo, e bokellana, e theha 'mele ea Lewy. Ho ba teng ha 'mele ea alpha-synuclein le Lewy bokong le ho pholletsa le tsamaiso ea methapo ke letšoao la lefu la Parkinson.

Aggregating alpha syncytia le eona e fumanoe ka maleng, 'me ho nahanoa hore kokoana-hloko e thehiloeng maleng e ka baka ho kopana, ebe e fetela bokong.

tummeng hofeta

E le ho leka ho utloisisa hamolemo lisosa tsa lefu la Parkinson, bafuputsi ba Univesithi ea Helsinki e Finland ba ile ba hlahloba karolo eo mofuta oa baktheria, haholo-holo Desulfovibrio, eo ka tloaelo e bitsoang DSV, e ka bang le eona.

Ke habohlokoa ho hlokomela hore kamano pakeng tsa baktheria e kotsi ea Desulfovibrio le lefu la Parkinson e ile ea etsoa lipatlisiso ka 2021. Ka nako eo, bafuputsi ba ile ba fumana hore baktheria e ne e atile haholo ho bakuli ba Parkinson. Ba fumane hore ho na le matšoao a matla a hlokometsoeng ho bakuli ba nang le keketseho e ntseng e eketseha ea libaktheria tsa DSV.

mefuta e khethehileng

Leha ho le joalo, thutong ea 2021, ha hoa hlahlojoa hore na libaktheria tsa DSV li kentse letsoho joang ho nts'etsopele ea lefu la Parkinson. Kahoo, ho Caenorhabditis elegans, bafuputsi ba ikemiselitse ho hlahloba hore na mefuta ea DSV e kenya letsoho ho bokelleng ha 'mele ea alpha-synuclein' me kahoo ho lefu la Parkinson.

'Me ba ile ba etsa qeto, ka mor'a liteko tsa laboratori, hore mefuta ea libaktheria tsa DSV tse tsoang ho batho ba nang le lefu la Parkinson, ho fapana le batho ba phelang hantle, li bonahala li le chefo ho feta' me li ka baka ho bokellana ha 'mele ea alpha-synuclein, e leng se bontšang hore liphetho tsa thuto li totobatsa ntho ea bohlokoa. karolo eo maemo a tikoloho a e phethang ho nts'etsopele ea tšoaetso. Parkinson's disease.

Liphetho tsa bohlokoa

Moelelong, Per Saris, sengoli-'moho le eena oa thuto, o itse, "Seo re se fumaneng ke sa bohlokoa, hobane sesosa sa lefu la Parkinson le ntse le sa tsejoe ho sa tsotellehe boiteko ba ho bo khetholla lilemong tse makholo a mabeli tse fetileng."

O ile a phaella ka ho re, "Liphetho li bontša hore mefuta e meng ea libaktheria tsa Desulfovibrio e ka 'na ea baka lefu la Parkinson, ke hore, le bakoa haholo-holo ke maemo a tikoloho," a hlalosa hore "ho pepeseha ha tikoloho ho mefuta ea baktheria ea DSV ho baka lefu la Parkinson," a hlokomela hore "Parkinson's lefu le fella ka Ke karolo e nyane feela, kapa hoo e ka bang 10%, ea liphatsa tsa lefutso e leng motho ka mong.

Ho tlosa libaktheria tse kotsi

O ile a boela a hlalosa hore, ho latela liphello tsa thuto, "bajari ba baktheria ena e kotsi ba ka fumanoa ho Desulfovibrio. Kahoo, li ka shejoa ka mekhoa ea ho ntša mefuta ena ka maleng, e ka ’nang ea kokobetsa le ho liehisa matšoao a lefu la Parkinson.”

Ho bontšoa hore lithuto tse ling tsa nakong e tlang li ka senola phapang pakeng tsa mefuta ea Desulfovibrio DSV, e 'nileng ea hlokomeloa ho batho ba nang le cerebral palsy le ba nang le bophelo bo botle.

Likhakanyo tsa linaleli tsa Maguy Farah tsa selemo sa 2023