Kalafo ea li-acne le manonyeletso hammoho !!!

Kalafo ea li-acne le manonyeletso hammoho !!!

Sehlopha sa bo-ramahlale se batlang liphekolo tse ncha tsa lefu la masapo a manonyeletso la letsoho se fihletse katleho e ncha e tšepisang nakong ea liteko tsa moriana o neng o etselitsoe ho phekola makhopho le psoriasis.

Bo-rasaense ba ile ba boela ba khona ho fumana hore lithethefatsi li ka thibela tsoelo-pele ea lefu la masapo a manonyeletso la letsoho ho mehlala ea liphoofolo tsa laboratori, 'me hona joale ba ntse ba sebetsa ho batho ho tiisa bokhoni ba eona e le phekolo e ncha ea kliniki, ho latela se hatisitsoeng ke New Atlas. makasine ea Science Translational Medicine.

retinoic acid

Patlisiso e entsoe ke bo-ramahlale ba Univesithing ea Oxford, ba ikemiselitseng ho ithuta ka mefuta e tloaelehileng ea lefutso le bitsoang ALDH1A2 le amanang le OA ea letsoho e matla. Bafuputsi ba tiisitse sehokelo sena ka ho nka lintlha tse tsoang boithutong ba UK Biobank, mme ba fumana lefufuru la articular ho bakuli ba 33 ba OA ha ba ntse ba etsoa opereishene.

Mehlala ena e ile ea boela ea ithutoa hammoho le mehlala ea liteko, e ileng ea nolofalletsa sehlopha ho tseba molek'hule e itseng e neng e le tlaase haholo ho batho ba kotsing e kholo. Molek'hule e bitsoa retinoic acid, 'me e entsoe ke lefutso la ALDH1A2. Ka tatellano ea RNA, bafuputsi ba ile ba khona ho bona kamano lipakeng tsa mefuta e fapaneng ea liphatsa tsa lefutso, acid e tlase ea retinoic, le ho ruruha ho bonoang ho OA.

Li-acne le psoriasis

Bafuputsi ba ile ba fetohela ho sethethefatsi se bitsoang Talarozole, se etselitsoeng ho thibela metabolism ea retinoic acid ho phekola makhopho, psoriasis le maemo a amanang le letlalo. Ha e sebelisoa manonyeletsong a mangole a mehlala ea litoeba, moriana o ile oa khona ho fokotsa kotsi ea lefufuru le ho ruruha ka mor'a lihora tse tšeletseng. Liphetho li ile tsa boela tsa phetoa ka manonyeletso a ex vivo porcine.

Osteoporosis le bohloko bo sa foleng

Dr Neha Essar-Brown, sengoli-'moho oa thuto le Motsamaisi oa Lipatlisiso tsa Bophelo bo Botle Univesithing ea Oxford, o itse: "Phuputso e ntse e le mothating oa pele, empa ka liphetho tsena tse khothatsang, re mohato o le mong o moholo o haufi le ho khona ho nts'etsapele. sehlopha se secha sa lithethefatsi tse ntlafatsang ho phekola lefu la ho fokola ha masapo le ramatiki.”

Hobane talarozole e na le boemo bo amohelehang ba polokeho ho batho, bo-ramahlale ba na le tšepo e kholo ea tsela e bonolo ea ts'ebeliso ea bongaka. Ba entse boithuto bo bong bo bonyenyane ba bopaki ba maikutlo ho bona hore na liphetho tsena tsa pele li ka phetoa, ba rala motheo oa mokhoa o mocha oa kalafo ho OA.

lipheo tsa tlhaho

Hape, Dr. Essar-Brown o ile a phaella, “Ho na le tlhokahalo e potlakileng ea liphekolo tsa ho fetola maloetse tse etselitsoeng ho thibela kapa ho khutlisa matšoao a bohloko a ramatiki ea lefuba. Phuputso ena e senola kutloisiso e ncha ea lisosa tsa osteoarthritis ea letsoho, e leng se ka lebisang ho khethoeng ha lipakane tse ncha tsa likokoana-hloko bakeng sa ho kenella ka har'a OA."