Na nanobodies e tla ba tharollo ho Corona?

Tekong ea pele ea li-nanobodies tse tšoanang le li-antibodies tsa monoclonal, empa li le nyane, li tsitsitse ebile li theko e tlase ho li hlahisa, bafuputsi ba American University of Pittsburgh School of Medicine ba bonts'itse hore li-nanobodies tse hemang tse lebisang "spike" protheine ea coronavirus e ntseng e hlaha, e ka ba teng. Ho thibela le ho alafa lefu le hlobaetsang.

Lintlha tsa phuputso e phatlalalitsoeng koranteng ea "Science Advances", 'me e entsoeng ka hamster, bafuputsi ba bontšitse hore litekanyetso tse tlaase tsa nanobody ea aerobic e bitsoang Nanobody - 21 "PiN - 21", e ka hemang e sireletsa hamster ho tloha boima bo hlollang. tahlehelo e atisang ho amahanngoa le tšoaetso e matla ea kokoana-hloko, 'me e fokotsa palo ea likaroloana tsa kokoana-hloko e tšoaetsanoang ka har'a masoba a nko, 'metso le matšoafo ka makhetlo a milione, ha ho bapisoa le phekolo ea placebo e sebelisang nanobody e sa feliseng phello ea kokoana-hloko.

O hlalositse hore ka ho sebelisa kalafo ea ho hema e ka fanoang ka kotloloho sebakeng sa ts'oaetso le matšoafong, re ka etsa hore liphekolo li atlehe, a supa hore tšepo e kholo, haholo kamora hore nanobody (PiN - 21) e netefatse seo. e ka sireletsa haholo khahlanong le mafu a matla, 'me e ka ba E thibela phetiso ea kokoana-hloko ho tloha ho motho e mong ho ea ho e mong.

Ente ke tharollo e molemohali

Bo-rasaense ba ile ba tlameha ho hlōla mathata a mangata a theknoloji phuputsong ena, kaha nanoparticles e tlameha ho fihla botebong ba matšoafo, 'me likaroloana tsa phekolo li lokela ho ba tse nyenyane ka ho lekaneng hore li se ke tsa kopana 'me li be matla ka ho lekaneng ho mamella khatello e feteletseng.

Li-nanobodies tsa PiN-21, tse batlang li le nyane ka makhetlo a 4 ho feta li-antibodies tse tloaelehileng tsa monoclonal tse nang le botsitso bo phahameng bo ikhethang, li loketse hantle bakeng sa mosebetsi ona, li theko e tlaase haholo ho li hlahisa, 'me li ka hlahisoa ka potlako ho ikamahanya le kokoana-hloko ea ho fetola sebōpeho.

Ntle le moo, bafuputsi ba bontšitse hore li-nanobodies le liente lia tlatsana ebile ha li qothisane lehlokoa, 'me liente e ntse e le eona tsela e molemohali ea ho thibela ho ata ha kokoana-hloko ho tloha ho motho e mong ho ea ho e mong.

O hlalositse hore li-nanobodies li tla thusa feela ho phekoleng batho ba seng ba kula, ba sa khoneng ho entoa ka mabaka a mang a bongaka.

Lihlooho tse ling:

U sebetsana joang le motho ea u hlokomolohang ka bohlale?

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