Qetellong.. Lithibela-mafu khahlanong le Omicron le Corona mutant

Sehlopha sa machaba sa saense se khethile li-antibodies tse fokotsang mofuta oa Omicron le mefuta e meng ea coronavirus e hlahang; Li-antibodies tsena li shebile libaka tsa protheine ea spike (spike) ea vaerase e lulang e sa fetohe ha livaerase li ntse li fetoha.
Ka ho hloaea lipheo tsa li-antibodies tsena tse "neathering" ka bongata protheine ea spike, ho ka khonahala ho rala liente le litlhare tsa antibody tse tla sebetsa hantle; Hase feela khahlanong le mefuta e fapaneng ea omicron empa hape le khahlanong le mefuta e meng e ka hlahang nakong e tlang, ho hlalosa David Weissler, mofuputsi Howard Hughes Medical Institute le motlatsi oa moprofesa oa biochemistry Univesithing ea Washington School of Medicine e Seattle.

Mme tšibollo ena e re joetsa hore "ka ho tsepamisa maikutlo ho li-antibodies tse shebileng libaka tsena tse sirelelitsoeng haholo ho protheine e sebiloeng, ho na le mokhoa oa ho hlola ts'ebetso e tsoelang pele ea vaerase," Wessler o re, tlalehong e phatlalalitsoeng webosaeteng ea Univesithi ea Washington.
Wessler o ile a etella pele morero oa lipatlisiso o fumaneng li-antibodies tsena, ka ts'ebelisano le sehlopha sa bafuputsi ba tsoang Switzerland, 'me a phatlalatsa liphello tsa mosebetsi oa bona khatisong ea morao-rao ea makasine ea Nature.
Lipalopalo tsa "Reuters" li bonts'itse hore batho ba fetang limilione tse 283.23 ba tšoaelitsoe ke kokoana-hloko e hlahang lefatšeng ka bophara, ha palo eohle ea batho ba shoang ka lebaka la vaerase e fihlile ho limilione tse 5 le 716,761.
Ts'oaetso e nang le vaerase e tlalehiloe linaheng le libakeng tse fetang 210 ho tloha ha linyeoe tsa pele li fumanoa Chaena ka December 2019.
Omicron mutant e na le liphetoho tse 37 tsa protheine ea mokokotlo eo kokoana-hloko e e sebelisang ho hokela le ho hlasela lisele tsa motho, e leng palo e phahameng ka ho sa tloaelehang ea liphetoho.
"Lipotso tsa sehlooho tseo re neng re leka ho li araba e ne e le, 'Sehlopha see sa liphetoho tse teng ka har'a protheine e fokolang ea omicron e ile ea ama bokhoni ba eona ba ho tlama lisele le ho qoba likarabelo tsa sesole sa 'mele oa ho itšireletsa mafung?'” ho bolela Fissler.
Wessler le basebetsi-'moho le eena ba hakanya hore palo e kholo ea liphetoho tsa omicron e ka 'na ea bokelloa nakong ea tšoaetso ea nako e telele, ho motho ea nang le tsamaiso ea' mele ea ho itšireletsa mafung e fokolang, kapa hobane kokoana-hloko e tlohile ho batho ho ea ho mofuta oa phoofolo le ho khutla hape.
Ho lekola phello ea liphetoho tsena, bafuputsi ba thehile vaerase e bitsoang "pseudovirus" ho hlahisa liprotheine tse spiky holim'a eona, joalo ka ha li-coronavirus li etsa, ebe ba theha li-pseudovirus tse nang le liprotheine tsa spiky tse nang le liphetoho tsa omicron le tse fapaneng tsa pele tse bonts'itsoeng seoa sena. .
Bafuputsi ba ile ba sheba pele ho bona hore na mefuta e fapaneng ea protheine ea barbed e khonne ho tlama protheine e holim'a lisele tseo vaerase e li sebelisang ho hokela le ho kena ka seleng. Protheine ena e bitsoa angiotensin-converting enzyme receptor (ACE2). .

Bafuputsi ba fumane hore protheine ea spiky e tsoang ho omicron e khona ho tlama makhetlo a 2.4 ho feta protheine ea spiky e fumanehang ka har'a vaerase e ikhethileng qalong ea seoa, mme ba fumane hape hore mofuta oa omicron o khonne ho tlama ho "ACE2" receptor. ka litoeba hantle, ho bontša hore omicron e ka khona ho feta lipakeng tsa batho le liphoofolo tse ling tse anyesang.
Bafuputsi ba ile ba sheba hore na li-antibodies li hlahisitsoe hantle hakae khahlano le mefuta e fetileng ea vaerase e sirelelitsoeng khahlano le mofuta oa omicron, mme ba etsa joalo ba sebelisa li-antibodies tse tsoang ho bakuli ba neng ba kile ba e-ba le mefuta e fetileng ea vaerase, ba neng ba entoa khahlanong le mefuta e fetileng ea vaerase, kapa ba ile ba tšoaetsoa eaba baa entoa. . Ba fumane hore li-antibody tse tsoang ho batho ba neng ba tšoaelitsoe ke mefuta e fetileng, le ho ba amohetseng e 'ngoe ea liente tse tšeletseng tse sebelisoang haholo tse teng hona joale, li fokolitse matla a ho thibela tšoaetso.
Lithibela-mafu tse tsoang ho batho ba tšoaelitsoeng, ba fola, 'me ba fumana litekanyetso tse peli tsa ente le tsona li ile tsa fokotsa tšebetso ea tsona; Empa ho fokotseha ho ne ho le tlase, ka makhetlo a ka bang 5, e leng se bontšang ka ho hlaka hore ente ka mor'a tšoaetso e molemo.

Sehlopheng sa bakuli ba dialysis ba fumaneng tekanyo ea booster, li-antibodies tsa barupeluoa li bontšitse ho fokotseha ha makhetlo a 4 mosebetsing oa ho se nke lehlakore. "Sena se bontša hore tekanyo ea boraro e hlile e thusa khahlanong le Omicron," ho bolela Weissler.
Bafuputsi ba fumane hore liphekolo tsohle ntle le e le 'ngoe ea li-antibody tse lumelletsoeng hajoale, kapa tse lumelletsoeng ho sebelisoa ho bakuli ba pepesehetseng vaerase, ha li na ts'ebetso, kapa li fokolitse ts'ebetso ea Omicron ka laboratoring haholo, mme mokhelo e ne e le antibody e bitsoang "sotrovimab" , e neng e le E na le makhetlo a 3 ho isa ho a XNUMX ho etsa mosebetsi o fokolang.
"Bana ba boemong bo thata" .. Joang ho sireletsa lelapa la hau ho Omicron?

Corona virus "bana ba maemong a thata" .. U sireletsa lelapa la hau joang ho Omicron?
Global Health: Tsunami e nang le likotsi tsa Corona ka lebaka la Omicron le Delta

Empa ha ba lekola sehlopha se seholo sa li-antibodies tse entsoeng khahlano le mefuta e fetileng ea vaerase, bafuputsi ba ile ba supa lihlopha tse 4 tsa li-antibodies tse bolokileng bokhoni ba tsona ba ho fokotsa omicron, mme litho tsa e 'ngoe le e 'ngoe ea lihlopha tsena li shebile e' ngoe ea libaka tse 4 tse ikhethang tsa protheine e meutloa. ha e fumanehe feela ho Mefuta e sa tšoaneng ea kokoana-hloko e hlahang ea "Corona", empa hape le sehlopheng sa li-coronavirus tse amanang le tsona, tse bitsoang "Sarbic" likokoana-hloko, 'me libaka tsena li ka' na tsa tsoela pele ka protheine; Hobane li etsa mosebetsi oa bohlokoa oo protheine e lahleheloang ke eona ha e fetoha, libaka tsena li bitsoa "li babaletsoe."
Ho sibolloa ha li-antibody li khona ho fokotsa, ka ho lemoha libaka tse sirelelitsoeng mefuteng e mengata e fapaneng ea kokoana-hloko, e fana ka maikutlo a hore moralo oa liente le litlhare tsa antibody tse lebisitseng libaka tsena li ka sebetsa khahlano le mefuta e mengata e fapaneng e hlahang ka liphetoho.