Bakuli ba khatello ea maikutlo ka mor'a ho sithabela maikutlo

Bakuli ba khatello ea maikutlo ka mor'a ho sithabela maikutlo

Sehlopha sa bafuputsi Univesithing ea Southern California se khonne ho etsa setšoantšo sa boko ba lizebrafish tse phelang ho bontša kamoo boko bo sebetsang kateng le ho boloka mehopolo ka thuto e matla e ka fanang ka tšepo bakeng sa phekolo e ncha bakeng sa lefu la khatello ea kelello ea morao-rao (PTSD).

Ka thuso ea microscope e entsoeng ka mokhoa o khethehileng, bafuputsi ba ile ba khona ho ngola kamoo lisele tsa boko ba tlhapi - tse bonaletsang bocheng ba tsona - li khantšitse ka limilione tsa mebala le mabone nakong ea teko.

'mapa oa liphetoho tsa boko

Thuto, e ileng ea etsa 'mapa oa liphetoho bokong, e lebisitse ho sibolloa ho makatsang hore mokhoa oa ho hopola lintho o bonahala o etsoa ka ho theha li-synapse tse ncha, kapa likamano pakeng tsa li-neurone, kapa ho li etsa hore li nyamele ka ho feletseng, ho fapana le seo khopolo e tloaelehileng e amohelehang e ka se bolelang. Ha re bua ka mokhoa o pharaletseng, ho ithuta le ho hopola lintho li matlafatsa likamano, kapa li-synapse, lipakeng tsa methapo ea kutlo.

Boithuto bona bo sebelisitse liqoaha hobane boko ba tsona bo ts'oana le boko ba motho, liphatsa tsa lefutso le lisele, 'me litlhapi tse nyane li na le pepeneneng - li lumella ponahalo ntle le ho etsa liphetoho leha e le life bokong ba tsona bo phelang.

"Lilemong tse fetileng tsa XNUMX, bohlale bo tloaelehileng e bile hore u ithuta ka ho fetola matla a li-synapses, empa se fumanoeng se fapane," mofuputsi Karl Kelsman o boletse khatisong ea khatiso.

Phetoho e makatsang

Le hoja mofuputsi ea ka sehloohong, Moprofesa Don Arnold, moprofesa Univesithing ea Southern California, a ile a phaella: “Phello e molemo ka ho fetisisa e ile ea finyelloa, hobane re ne re ka bona phetoho ena e hlollang palong ea li-synapse—tse ling li nyamela, tse ling li bōptjoa, le [tse hlahang]. karolong e ikhethang haholo ea boko.” . [Tumelo e tloaelehileng] e ne e le hore li-synapse li fetola matla a tsona. Empa ntho e makatsang e ne e le ho bona ketsahalo ea ho sututsa le ho hula, ’me ho ne ho se na phetoho matleng a li-synapse.”

Ka ho lumella bo-rasaense ho latela le ho bolela liphetoho tsa likhokahano lipakeng tsa li-neurone, teko e ka thusa ho bonts'a hore na mehopolo e thehoa joang bokong ba motho le hore na hobaneng mefuta e meng ea mehopolo e matla ho feta e meng, ho seo bafuputsi ba lumelang hore se ka fana ka katleho kalafong e ncha ea PTSD. PTSD e Tloaelehileng le Maloetse a Neurodegenerative.

Ho amygdala, eseng hippocampus

Hoa etsahala hore mehopolo e mebe e bonahala e hlaha karolong e fapaneng ea boko ho feta mehopolo e meng e mengata ea amygdala, e ikarabellang bakeng sa likarabo tsa maikutlo tse kang ntoa kapa ho fofa.

Moprofesa Arnold o ile a hlalosa: “Ho ne ho nahanoa hore ho thehoa ha mohopolo ho akarelletsa haholo-holo ho lokisoa ha likhokahano tse teng tsa synaptic ha phuputsong ena, re ile ra fumana hore li-synapse li ntse li etsoa le ho tlosoa, ha ho ile ha bonoa feela liphetoho tse nyenyane, tse sa reroang tsa matla a synaptic [a methapo ea methapo]. e teng.”

Sena se ka bakoa ke taba ea hore phuputso ena e tsepamisitse maikutlo mehopolong ea likamano, tse matla haholo ho feta mehopolo e meng, 'me li thehoa sebakeng se fapaneng bokong, [haholo-holo ho] amygdala, khahlano le hippocampus bakeng sa mehopolo e meng e mengata. 'Me [ho sibolloa hona] ka letsatsi le leng ho ka ba le kamano le PTSD, eo ho nahanoang hore e etsahala ka ho thehoa ha mehopolo e kopanetsoeng.

microscope e tsotehang

Ho sebelisa microscope e ncha e tsoetseng pele, e qapiloe Univesithing ea Southern California, bafuputsi ba ile ba khona ho ithuta boko ba litlhapi ka lilemo tse tšeletseng le ho bapisa li-synapses le liphetoho tsa synaptic tsa methapo ea kutlo, e leng se lebisang ho "katleho lefapheng la neuroscience."
Mongoli-'moho le eena Moprofesa Scott Fraser o ile a phaella ka hore "microscope [e sebelisitsoeng thutong] e etselitsoe ho rarolla phephetso ea ho nka litšoantšo le ho ntša tsebo eo bo-rasaense ba lokelang ho e fumana."

Laser, Fluorescent, le algorithms

Fraser, Arnold le Kiselman ba koetliselitse liqoaha ho amahanya ho chesa ha lebone la lesela la infrared le hlahisoang lihloohong tsa bona ka maikutlo a sa thabiseng. Litlhapi, tseo DNA ea tsona e fetotsoeng e le hore li-synapse li ka khetholloa ka protheine ea fluorescent e khanyang ha e khantšitsoe ke mahlaseli a laser, e leka ho qoba laser ka ho sesa, 'me litlhapi tse hopolang mokhatlo li phunya mehatla ha lebone le khantšitsoe. esita le ntle le laser.

Lihora tse hlano ka mor'a ho pepeseha ha laser ea pele, bafuputsi ba ile ba lekanya liphetoho tse kholo ho li-neuron synapses tsa boko ba litlhapi le mosebetsi oa neuronal. Liphetho li ile tsa hlahlobjoa ka thuso ea li-algorithms tse ncha tse ntlafalitsoeng ho beha leihlo ho fetoha ha mekhoa e hokahaneng.

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