Ke kamano efe pakeng tsa zinki le mafu?

Ke kamano efe pakeng tsa zinki le mafu?

Bafuputsi ba fumane mokhoa oa liphatsa tsa lefutso ka morao ho karolo ea ts'ireletso ea zinki ho lefu la tsoekere la mofuta oa 2 le lefu la sebete le mafura le amanang le boemo bona. Liphetho li matlafatsa kutloisiso ea ts'ebetso ea metabolism le ho bula monyetla oa nts'etsopele ea kalafo e ncha ea lefu la tsoekere, ho latela se phatlalalitsoeng ke webosaete ea New Atlas, ho qotsa koranta ea Genetics and Genomics.

Lelapa la lipalangoang tsa zinki

Zinc e thusa ka tšebetso ea 'mele ea ho itšireletsa mafung, kholo ea lisele le karohano, motsoako oa DNA, le metabolism. Ka lebaka la bohlokoa ba eona, 'mele oa motho o thehile mekhoa ea ho boloka maemo a zinki. Mokhoa o mong o joalo o kenyelletsa gene e bitsoang Solute Carrier Family 39, Member 5, e khutsufalitsoeng SLC39A5, e kenyelletsang protheine ea lelapa la li-zinc transporter e tsamaisang zinki liseleng.

Khokahano lipakeng tsa zinki le lefu la tsoekere

Liphuputso tse fetileng li fumane kamano pakeng tsa zinki le ho ntlafatsa maemo a tsoekere ea mali ho batho ba nang le lefu la tsoekere, empa "joang" e ne e sa utloisisoe ka botlalo, e leng se ileng sa susumelletsa bafuputsi ho hlahloba mochine o ka sehloohong, ho qala ka SLC39A5.

"Rea tseba hore ho eketseha ha zinki ho ntlafatsa taolo ea tsoekere ea mali ho batho ba nang le prediabetes kapa lefu la tsoekere la mofuta oa XNUMX, 'me batho ba nang le phetoho ea protheine ea bohlokoa ea lipalangoang ba na le kotsi e fokolang ea ho ba le lefu la tsoekere," ho boletse Shek Man Chim, mofuputsi ea ka sehloohong oa thuto. Lefu la tsoekere,” a hlokomela hore “mochine oo zinki e amang tsoekere ea mali le kotsi ea lefu la tsoekere o ntse o sa hlaka.”

Sebete, masapo, liphio le boko

Bafuputsi ba ile ba hlahlobisisa lithuto tse 'ne tsa Europe le US tse shebaneng le liphetoho tse sa sebetseng ho SLC39A5 har'a bakuli ba lefu la tsoekere ba fetang 62000 le taolo e fetang 518000 ea bophelo bo botle. Liphetho tsa tlhahlobo li netefalitse hore maemo a potolohang a zinki ho bajari ba phetoho ea SLC39A5 a ne a le holimo mme a amahanngoa le kotsi e tlase ea lefu la tsoekere.

Kamora ho fihlela liphetho tsena, bafuputsi ba ile ba hlakola mofuta oa SLC39A5 ho litoeba tsa laboratori, hoo ba neng ba haelloa ke protheine ea lipalangoang tsa zinki. Hoa etsahala hore litoeba li na le zinki tse ngata ho potoloha ha tsona, le hore ho na le keketseho ea hoo e ka bang 280% ho litoeba tse tšehali le hoo e ka bang 227% ho banna ha ho bapisoa le taolo. Maemo a ne a le holimo haholo ho lisele, haholo-holo sebeteng, masapong, liphio le bokong, empa a le tlase ho manyeme. Maemo a phahameng a zinki ha aa ka a ama liphio kapa sebete hampe ho litoeba tsa laboratori.

Ho fokotseha hoa insulin

Ka mor'a ho phephetsa litoeba tse kokotang ka lijo tse nang le mafura a mangata, a phahameng a fructose ho etsa hore botenya, bafuputsi ba ile ba bona ho fokotseha ho hoholo ha tsoekere ea ho itima lijo ho bapisoa le litoeba tse neng li feptjoa lijo tse tšoanang. Tahlehelo ea SLC39A5 e boetse e lebisitse ho fokotseng ho hanyetsa insulin, e leng letšoao la lefu la tsoekere moo lisele li sitoang ho arabela lipontšo tsa insulin tse etselitsoeng ho amohela tsoekere ka lisele.

E ntlafatsa kutloisiso ea insulin

Hobane lefu la tsoekere le atisa ho ba le lefu la sebete le se nang tahi (NAFLD), bafuputsi ba ile ba hlahloba hore na ho felisa SLC39A5 ho boetse ho thusa sebete. Bafuputsi ba fumane hore litoeba tsa laboratori tse neng li se na liphatsa tsa lefutso li ne li e-na le mafura a fokolang sebeteng le matšoao a fokolang a mali a bontšang tšenyo ea sebete. Ho litoeba tse nonneng tse haelloang ke SLC39A5, bafuputsi ba ile ba bona ho bokellana ha mafura a fokolang ka har'a sebete le ho ntlafatsa kutloisiso ea insulin ho bapisoa le taolo.

Ho fokotsa ho ruruha le fibrosis

NAFLD e ka fetoha mofuta o tsoetseng pele o bitsoang nonalcoholic steatohepatitis (NASH), e bakang ho ruruha ha sebete le maqeba a lisele, a tsejoang e le "cirrhosis." Bafuputsi ba fumane hore ho tlosa SLC39A5 ho litoeba tsa laboratori tse nonneng ho lebisitse ho fokotseng matšoao a tšenyo ea sebete le ho itima lijo ha maemo a tsoekere ea mali le ho ntlafatsa ho ruruha le fibrosis.

Mokhoa oa phekolo o ka bang teng

Harikiran Nistala, mofuputsi-'moho le eena thutong ena, o itse "e fana ka bopaki ba liphatsa tsa lefutso ka lekhetlo la pele bo pakang karolo ea tšireletso ea zinki khahlanong le tsoekere e phahameng ea mali, 'me e senola motheo oa mochine oa phello ena," a re "ho thibela SLC39A5 mokhoa o ka bang teng oa ho phekola lefu lena.”

Likhakanyo tsa linaleli tsa Maguy Farah tsa selemo sa 2023