Ungazifumana njani iingenelo zemidlalo ngendlela efanelekileyo?

Ungazifumana njani iingenelo zemidlalo ngendlela efanelekileyo?

Abaphandi baseBaylor naseStanford Colleges of Medicine kunye namaziko abo asebenzisanayo babika ingxelo epapashwe kwiNdalo "Baye bakwazi ukuchonga i-molecule egazini eveliswa ngexesha lokuzivocavoca kwaye inokunciphisa ngokufanelekileyo ukutya kunye nokukhuluphala kwiigundane.

Ngokutsho kweNeuroscience News, iziphumo ezitsha zinokuba negalelo ekuphuculeni ukuqonda kwezazinzulu ngeenkqubo zefiziyoloji ezisisiseko sokusebenzisana phakathi komthambo kunye nokunciphisa indlala.

ukunciphisa ukutyeba

"Ukuzivocavoca rhoqo kuye kwaboniswa ukunceda ukunciphisa umzimba, ukulawula ukutya kunye nokuphucula iphrofayili ye-metabolic, ngakumbi kubantu abagqithisileyo kunye nabatyebileyo," watsho umlobi-mbhali wesifundo uDkt. Yong Shu, unjingalwazi wezingane, isondlo kunye ne-biology ye-molecular Baylor College.

“Ukuba thina (abaphandi) sinokuyiqonda indlela umthambo okhokelela ngayo kwezi zibonelelo, sikufutshane ekuncedeni abantu abaninzi ukuba baphucule impilo yabo,” wongeze watsho.

"Ukuqonda indlela ukuzivocavoca okusebenza ngayo kwinqanaba le-molecular kuya kusivumela ukuba sikwazi ukuvuna ezinye zeenzuzo zayo," watsho umbhali-mbhali uProfesa Jonathan Long, uprofesa oncedisayo we-pathology eStanford Medicine kunye nomphandi kwi-Stanford Chem-H Institute.

Abantu abadala nababuthathaka

"Ngokomzekelo, abantu abadala okanye ababuthathaka abangakwaziyo ukwenza umthambo ngokwaneleyo ngenye imini banokuzuza ngokuthatha iyeza elinokunceda ukucotha i-osteoporosis, isifo senhliziyo, okanye ezinye iimeko," wongezelela.

Amino acids

Xu, Long kunye noogxa babo benze uhlalutyo olubanzi lweekhompawundi zeplasma yegazi ezithathwe kwiimpuku emva kokubaleka ngamandla kwi-treadmill. Eyona molekyuli yayiyi-amino acid elungisiweyo ebizwa ngokuba yiLac-Phe. Yenziwe kwi-lactate, eyi-byproduct yokuzivocavoca okunzima, okubangela "ukutshisa" imvakalelo kwimisipha, kunye ne-phenylalanine, i-amino acid enye yeebhloko zokwakha iiprotheni.

ukunyamezela kweglucose

Iimpuku ezityebileyo ezinikwe ukutya okunamafutha aphezulu zinciphise ukutya okutyiwayo malunga ne-50% xa kuthelekiswa nolawulo lweempuku kwisithuba seyure ye-12, ngaphandle kokuchaphazela ukuhamba kwazo okanye inkcitho yamandla. Xa ilawulwa kwiigundane iintsuku ze-10, i-Lac-Phe yanciphisa ukutya okuqokelelweyo kunye nobunzima bomzimba (ngenxa yokulahlekelwa kwamafutha omzimba) kunye nokuphucula ukunyamezela kwe-glucose.

Ukusilela kwe-enzyme ye-CNDP2

Abaphandi bafumanisa ukuba i-enzyme ebizwa ngokuba yi-CNDP2 ibandakanyeka ekuveliseni i-Lac-Phe kwaye ukuba iigundane ezilahlekileyo kule enzyme azizange zilahlekelwe ubunzima obuninzi kwi-regimen yokuzivocavoca njengoko zenza kunye neqela lokulawula kwisicwangciso esifanayo sokuzivocavoca.

Ukwanda okumangalisayo

Okubangel 'umdla kukuba, iqela labaphandi liye lafumanisa ukuphakama okuqinileyo kwi-plasma Lac-Phe amanqanaba emva kokusebenza ngokomzimba kumahashe kunye nabantu. Idatha evela kwiqela labantu elenza i-aerobic exercise efana nokugijima ibonise ukuba kukho ukwanda okumangalisayo kumanqanaba e-Lac-Phe, avela emva kokugijima emva kokuqeqeshwa kokumelana kunye nokuqeqeshwa kokunyamezela.

"Iqela lethu (iqela labaphandi) amanyathelo alandelayo abandakanya ukufumana iinkcukacha ezingakumbi malunga nendlela iLac-Phe edibanisa ngayo imiphumo yayo emzimbeni, kubandakanywa nengqondo," kusho uDkt Shaw. "Injongo kukufunda ukuguqula indlela yokuzivocavoca ngeenjongo zonyango. "