Uphando olutsha ekunyuseni ukuchuma kwabasetyhini

Uphando olutsha ekunyuseni ukuchuma kwabasetyhini

Ukuzala kowasetyhini kuthanda ukwehla ukususela kwiminyaka yakhe ephakathi kwama-30, nto leyo enokwenza kube nzima ukuba nabantwana kwiminyaka ephakathi. Iqela lezazinzulu kutshanje lifumene indlela ebonakala ikhawulezisa ukuguga kwama-ovari, kwaye baye bafumanisa indlela, ubuncinci kwiimpuku ukuza kuthi ga ngoku, ukuyicothisa ukukhulisa ukuchuma kamva ebomini, ngokutsho kweNew Atlas, icaphula. ulindixesha Nature Aging.

Ukungalungi kokufakwa kwamadlozi okwenziwa

Akukho malungu aguga ngesantya esifanayo, kwaye ngelishwa ii-ovari lelinye lamalungu afumana le ngxaki ngokukhawuleza, kodwa izazinzulu aziqinisekanga ngokupheleleyo ukuba kutheni. Ukuqala kwiminyaka engama-35 ubudala, ama-ovari akhula ngokukhawuleza, okukhokelela ekunciphiseni umgangatho weqanda kunye nempumelelo ekukhulelweni. Izigulana ezininzi zibhenela ekufakeleni amadlozi ngokwenziwa, kodwa yindlela esenokubiza imali eninzi nezisa iingozi ezintsha.

Ufuzo lwe-CD38

Kuphononongo olutsha, izazinzulu kwiDyunivesithi yaseZhengzhou eTshayina zaphanda iindlela zebhayoloji ezinokuba semva koku kwehla. Bahlalutya iipateni zokubonakaliswa kofuzo kwiimpuku ezincinci, malunga neenyanga ezimbini ubudala, kunye neempuku ezikwiminyaka ephakathi, malunga neenyanga ezisibhozo ubudala, kuma-ovari nakwamanye amalungu.

Abaphandi bafumanise ukuba kwiimpuku ezindala, ukubonakaliswa kwejini ebizwa ngokuba yi-CD38 kunyukile, ngakumbi kuma-ovari. Oku akuzange kumangalise ngokupheleleyo, njengoko i-CD38 iyindawo eyaziwayo yokuguga, kuba ivelisa i-enzyme ephula iprotheyini ebizwa ngokuba yi-NAD+, eyathi kamva yafunyanwa kumanqanaba asezantsi kakhulu kwiimpuku ezisele zikhulile.

Umgangatho weeseli kunye namaqanda

Iprotheyini ye-NAD, kunye nefomu yayo ene-oxidized NAD +, ilawula i-cell metabolism kunye nokulungiswa kwe-DNA, kwaye ngokwemvelo iyehla ngobudala. Amanqanaba aphezulu adityaniswa nobomi obude kunye nempilo engcono njengeminyaka enye, ngoko kuye kwaba yingqwalasela yophando lwangoku lokulwa nokuguga, kunye neziphumo ezithile ezithembisayo. Ngoku kubonakala ngathi lo nobangela uxhaphakileyo ukwangunobangela wokuhla okunxulumene neminyaka ekuchumeni.

"Oku kuncipha kwe- [NAD +] kubonisa uthotho lweziphumo ezibi, ngakumbi ezichaphazela umgangatho wazo zombini iiseli ze-somatic kunye namaqanda, ngaloo ndlela zenza impembelelo enkulu ekuchumeni kwabasetyhini," utshilo uQingling Yang, umphandi kwisifundo esitsha.

Uphando ngeempuku

Kuvavanyo olulandelayo, iqela licime ijini ye-CD38 kwiimpuku ezindala - kwaye ngokuqinisekileyo, iziphumo bezingaphezulu, amaqanda akumgangatho ophezulu. Abaphandi baqala ke iimvavanyo ukubona ukuba isiphumo esifanayo sinokufezekiswa ngaphandle kobunjineli bemfuza, ukuyenza ibe lunyango olunokwenzeka ngakumbi lokuchuma.

izilingo zeklinikhi

Ukongeza, abaphandi bajikela kwimolekyuli ebizwa ngokuba yi-78c, ethintela i-CD38, kwaye yanikwa iimpuku zasebhubhoratri ezineenyanga ezisibhozo ubudala ngokwemvelo. Ngokuqinisekileyo, amanqanaba e-NAD + anda kwii-ovari, kwaye iimpuku zakwazi ukuzala ngaphezulu.

Ulingo lwezonyango luyenziwa ngoku ukubona ukuba ukonyusa amanqanaba e-NAD+ kubasetyhini abafumana unyango oluncediswayo lokuzala kunokuphucula amazinga empumelelo kunye nokunciphisa umngcipheko weziphene zokuzalwa.

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