Ekugqibeleni ... ukufunyanwa kwesizathu se-Alzheimer's disease

Ekugqibeleni ... ukufunyanwa kwesizathu se-Alzheimer's disease

Abaphandi abavela kwiYunivesithi yaseCalifornia badize kuphononongo lokuba isifo sika-Alzheimer sinokubangelwa kukucotha kokukwazi ukucoca iiseli ngokwazo, ngokutsho kwephephandaba laseBritani, iDaily Mail.

Uphononongo longezelela ukuba ukucotha kwabonwa kubantu abangaphezu kweminyaka yobudala be-65, eyona nto inokubangela ukuqokelela okungenampilo kwingqondo.

i-autophagy

Ukucotha, okwaziwa ngokuba yi-autophagy, kunokubangelwa kukuzila ukutya, apho iiseli zingafumani iprotheyini eyaneleyo kukutya komntu, kwaye zigcwalisa isithuba ngokuphinda kusetyenziswe iiproteni esele zikwiseli.

Emva koko, uRyan Julian, unjingalwazi wekhemistri kwiYunivesithi yaseCalifornia, owayekhokela isifundo, wathi iziyobisi sele zivavanyelwa ukuphucula i-autophagy, kwaye ukuba le yimbangela yesifo se-Alzheimer, sinokubona ichiza elinokuthi lithintele kwi-autophagy. kwixesha elizayo elikufuphi.

"Ukuba ukucotha kwi-autophagy kungunobangela wengcambu, ke izinto eziyandisayo kufuneka zibe nefuthe eliluncedo kunye nelinye," wongeze watsho.

Nangona kunjalo, uchaze kwingxelo, "Malunga ne-20% yabantu banamacwecwe, kodwa akukho zimpawu zokuphazamiseka kwengqondo. Oku kwenza kubonakale ngathi imizobo ngokwayo ayingunobangela.”

Decode

Kwaye yena noogxa bakhe basenokuba bakwazi ukusiqonda esi sifo ngokujonga iiproteni ezingaphakathi kwengqondo.

Ngeli xesha, iqela laqala isifundo ngokugxila kwiiprotheni ze-tau, eziye zafunyaniswa ukuba ziphazamisekile ngokungaqhelekanga kwiingqondo zabantu abanesifo se-Alzheimer's.

Iiprotheyini zeTau zinceda ukuzinzisa amathambo angaphakathi kwiiseli zemithambo-luvo, ezaziwa ngokuba ziineurons, ebuchotsheni.

Kodwa nangona kwakunzima ukubhaqa, uhlobo olwahlukileyo lwe<em>tau lwaluvumela izazinzulu ukuba zikwazi ukwahlula abantu abangakhange babonakalise nayiphi na imiqondiso yangaphandle ye<em>dementia kwabo bayibonakalisayo.

Isomers

Ilebhu kaJulian eyunivesithi igxile kwiindlela ezahlukeneyo ezinokuthathwa yimolekyuli enye, ebizwa ngokuba yi-isomers, ekwancede ukuba zikhombe kumoni.

"I-isomer yimolekyuli enye eneendlela ezahlukeneyo zokuqhelaniswa ne-dimensional ukusuka kweyokuqala," utshilo uJulian.

Ukongeza, iqela livavanye zonke iiproteni kwiisampulu zobuchopho ezinikezelweyo.

Yadiza ukuba abo banobuchopho obude kodwa bengenawo ukuncipha kwengqondo babene<em>tau eqhelekileyo, ngoxa uhlobo olwahlukileyo lwe<em>tau lwafunyanwa kwabo baye bavelisa amacwecwe okanye i<em>tangles kwakunye nesifo sengqondo esiyingozi.

Kwakhona, iiprotheyini ezininzi emzimbeni zinesiqingatha-ubomi obungaphantsi kweeyure ezingama-48, kodwa ukuba zifunyenwe zihleli, ezinye ze-amino acids zinokuguqulelwa kwenye i-isomer.

Kuthiwa i-Alzheimer's yafunyanwa nguGqirha Alius Alzheimer ngo-1906, owabona utshintsho kwizicubu zobuchopho zowasetyhini owabulawa sisifo sengqondo esingaqhelekanga.

Oogqirha bahlala bexilonga isifo se-Alzheimer xa befumana umxube we-amyloid plaques kunye ne-neurofibrillary tangles, kunye nemilinganiselo.

Ukwakheka okungaqhelekanga kwaziwa ngokubangela isifo sika-Alzheimer, esiquka iindidi ezimbini zeeproteni: enye ebizwa ngokuba yi-amyloid, iidiphozithi zayo zenza amacwecwe ajikeleze iiseli zobuchopho, kunye nenye ebizwa ngokuba yi-tau, eyenza i-tangles ngaphakathi kweeseli zobuchopho.

Amanani ahlukeneyo e-cosmic kunye nobudlelwane babo kwinyani